Changes in the abundance of protein and RNA molecules can impair the formation of complexes in the cell leading to toxicity and death. Here we exploit the information contained in protein, RNA and DNA interaction networks to provide a comprehensive view of the regulation layers controlling the concentration‐dependent formation of assemblies in the cell. We present the emerging concept that RNAs can act as scaffolds to promote the formation ribonucleoprotein complexes and coordinate the post‐transcriptional layer of gene regulation. We describe (...) the structural and interaction network properties that characterize the ability of protein and RNA molecules to interact and phase separate in liquid‐like compartments. Finally, we show that presence of structurally disordered regions in proteins correlate with the propensity to undergo liquid‐to‐solid phase transitions and cause human diseases. Also see the video abstract here https://youtu.be/kfpqibsNfS0. (shrink)

This study presents the design and selected results of a comprehensive research on measuring the concept of sustainable entrepreneurship. We used the methodology of conjoint analysis and developed a hierarchical framework that lists all the multi-attributes that exist in the triple bottom line concept. In doing so, we collected data from 150 Greek food companies. The multi-attributes were categorized and ranked into the following four headings: internal social values, external social values, environmental values and economic values. Specifically, we found that (...) the creation of values that improve the safety and hygiene issues of products to consumers is the most important attribute for the ISV domain. Respectively, the most important attribute for the ESV domain is the creation of values that impact on the local economy. Accordingly, the creation of values for minimizing environmental impacts was found as the most important attribute for the ENV domain. And lastly, the establishment of ECV that increase long-run profitability was identified as the most important for the ECV dimension. Finally, all the categorized values offer rich feedback for entrepreneurship scholars and parishioners. And, to that extent, our findings are slightly different from those reported in previous researches to other contexts, as we have managed to build an aggregated instrument that promotes the hybrid nature of food companies towards international development. (shrink)

‘Neokantianism and Platonism’ indicates an important issue of Neo-Hellenic Philosophy during the 1920s and the 1930s. The protagonist was Johannes Theodorakopoulos. His Heidelberg dissertation Platons Dialektik des Seins (1927) follows the Neokantian theories of judgement (of Emil Lask and Heinrich Rickert) and explores Plato’s theory of judgement with emphasis on Philebos’ categories of peras and apeiron. Theodorakopoulos’ prolegomena to the Greek translation (1929) of Paul Natorp’s Platos Ideenlehre are relevant here. Nevertheless, Theodorakopoulos developed a personal interpretation of Plato’s philosophy and (...) almost demoted the Neokantian interpretation, as is clear in his Introduction to Plato (1941, in Greek) as also in his Heidelberg Vorlesungen 1969 entitled Die Hauptprobleme der Platonischen Philosophie. Besides, other interpretations of Plato came forward. Evangelos Papanoutsos wrote his Tübingen dissertation Das religiöse Erlebnis bei Platon (1926) under the supervision of Adickes. Konstantinos Georgoules, an earlier student of Husserl and Heidegger, published a translation of Plato’s Politeia (1939, in Greek) with a rather philological introduction.The Marxist Demetres Glenos, an opponent of Neokantianism, proposed a realistic interpretation of Plato’s Sophistes (1939, in Greek). Basileios Tatakes (an adherent of Henri Bergson) presented Plato’s philosophy as a reconciliation of reason and mysticism. (shrink)