It has been demonstrated that death certificates do not accurately record the actual cause of death in up to one-fourth of cases, as determined from subsequent autopsy findings. The purpose of this study was to explore the use of natural language autopsy data bases as an automated quality assurance mechanism. We translated the account of the major process leading to death, or the primary diagnosis, from all 45,564 narrative autopsy reports obtained at The Johns Hopkins Hospital between May 28, 1889, (...) and June 30, 1987, into the hierarchical system of Medical Subject Heading (MeSH) titles. We obtained a total of 125,772 MeSH title translations, 1,563 of them distinct (average 2.8 per case), ranging in frequency from 6,029 occurrences of LUNG to 1 occurrence apiece of 357 MeSH titles. The natural-language-to-MeSH translations showed expected trends over the past century: fewer infectious diseases; more cardiovascular and neoplastic disease among adults; and more respiratory diseases and congenital malformations in the pediatric age group. The greater availability of autopsy documents in electronic form should increase the value of this resource for quality assurance. (shrink)

While positive information in the context of clinical care can lead to placebo effects, negatively framed information can have negative or nocebo effects. Extant literature documents how doctor–patient encounters are fertile ground for suboptimal interactions leading to negative experiences for ethnoracial minority patients. In their _JME_ paper, Blease presents a critical perspective on the potential for patients’ access to their doctors’ clinical notes, ‘open notes’, to engender nocebo effects. 1 In this commentary, we affirm the central claim that nocebo effects (...) could emerge ‘via negative wording or framing of health information expressed by clinicians in documentation’. The advent of electronic health records (EHR) allowed patients the unprecedented opportunity to access personal clinical documentation, giving them a window into decision making around their health. This shift is undoubtedly complex, and thus warrants a more fulsome rendering of the unique challenges faced by ethnoracial minority patients. Herein, we highlight three... (shrink)

In the past, hypothesis testing in medicine has employed the paradigm of the repeatable experiment. In statistical hypothesis testing, an unbiased sample is drawn from a larger source population, and a calculated statistic is compared to a preassigned critical region, on the assumption that the comparison could be repeated an indefinite number of times. However, repeated experiments often cannot be performed on human beings, due to ethical or economic constraints. We describe a new paradigm for hypothesis testing which uses only (...) rearrangements of data present within the observed data set. The token swap test, based on this new paradigm, is applied to three data sets from cardiovascular pathology, and computational experiments suggest that the token swap test satisfies the Neyman Pearson condition. (shrink)

THE fifteenth edition of the Encyclopaedia Britannica is another of the projects undertaken by philosophers Robert M. Hutchins and Mortimer Adler. Hutchins chaired the Board of Editors, while Adler served as director of planning. This latest edition has the distinction of being the largest single private publishing venture in history, involving a thirty-two million dollar investment, over fifteen years of effort, and many thousands of consultants and contributors. This essay will attempt to assess philosophy’s share in so massive (...) an undertaking. (shrink)

Cognitive ecology is the study of cognitive phenomena in context. In particular, it points to the web of mutual dependence among the elements of a cognitive ecosystem. At least three fields were taking a deeply ecological approach to cognition 30 years ago: Gibson’s ecological psychology, Bateson’s ecology of mind, and Soviet cultural-historical activity theory. The ideas developed in those projects have now found a place in modern views of embodied, situated, distributed cognition. As cognitive theory continues to shift from units (...) of analysis defined by inherent properties of the elements to units defined in terms of dynamic patterns of correlation across elements, the study of cognitive ecosystems will become an increasingly important part of cognitive science. (shrink)

We are quickly passing through the historical moment when people work in front of a single computer, dominated by a small CRT and focused on tasks involving only local information. Networked computers are becoming ubiquitous and are playing increasingly significant roles in our lives and in the basic infrastructure of science, business, and social interaction. For human-computer interaction o advance in the new millennium we need to better understand the emerging dynamic of interaction in which the focus task is no (...) longer confined to the desktop but reaches into a complex networked world of information and computer-mediated interactions. We think the theory of distributed cognition has a special role to play in understanding interactions between people and technologies, for its focus has always been on whole environments: what we really do in them and how we coordinate our activity in them. Distributed cognition provides a radical reorientation of how to think about designing and supporting human-computer interaction. As a theory it is specifically tailored to understanding interactions among people and technologies. In this article we propose distributed cognition as a new foundation for human-computer interaction, sketch an integrated research framework, and use selections from our earlier work to suggest how this framework can provide new opportunities in the design of digital work materials. (shrink)

Hutchins examines a set of phenomena that have fallen between the established disciplines of psychology and anthropology, bringing to light a new set of relationships between culture and cognition.

This paper reviews the uneven history of the relationship between Anthropology and Cognitive Science over the past 30 years, from its promising beginnings, followed by a period of disaffection, on up to the current context, which may lay the groundwork for reconsidering what Anthropology and (the rest of) Cognitive Science have to offer each other. We think that this history has important lessons to teach and has implications for contemporary efforts to restore Anthropology to its proper place within Cognitive Science. (...) The recent upsurge of interest in the ways that thought may shape and be shaped by action, gesture, cultural experience, and language sets the stage for, but so far has not fully accomplished, the inclusion of Anthropology as an equal partner. (shrink)

This theory accords to volitions the status of basic mental actions, maintaining that these are spontaneous exercises of the will--a "two-way" power which ...

In cognitive neuroscience, functional magnetic resonance imaging is used to produce images of brain functions. These images play a central role in the practice of neuroscience. In this paper we are interested in how these brain images become understandable and meaningful for scientists. In order to explore this problem we observe how scientists use such semiotic resources as gesture, language, and material structure present in the socially and culturally constituted environment. A micro-analysis of video records of scientists interacting with each (...) other and with fMRI images reveals action as cognition, that is, actions that constitute thinking for the scientists. (shrink)

The present study investigated how knowledge-gaps, measured by feeling-of-knowing, and individual differences in epistemic curiosity contribute to the arousal of state curiosity and exploratory behaviour for 265 (210 women, 55 men) university students. Participants read 12 general knowledge questions, reported the answer was either known (“I Know”), on the tip-of-the-tongue (“TOT”), or unknown (“Don't Know”), and indicated how curious they were to see each answer, after which they could view any answers they wanted. Participants also responded to the Epistemic Curiosity (...) (EC) and Curiosity as a Feeling-of-Deprivation (CFD) scales. “TOT” was associated with the smallest knowledge-gap, most curiosity and exploration, and feelings of uncertainty and tension as measured by the CFD scale. “Don't Know” corresponded with the largest knowledge-gap, less curiosity and exploration, and positive feelings of interest as measured by the EC scale. “I Know” states, which reflected the absence of a knowledge-gap, involved the least curiosity and exploration. (shrink)

This chapter argues that the human perspective is not fully reducible – that is, that something would indeed be lost in the absence of the human perspective. It shows that epistemic subjectivity itself is an irreducible, ineliminable feature of the human standpoint. Subjectivity goes along with substantiality, and to be an epistemic subject is to be a substance with a mind. In E2p13, Spinoza identifies the mind's object with the body, thereby specifying where the multiplicity of epistemic subjects comes from (...) – how, that is, individual epistemic subjects are identified and differentiated. The chapter looks at how the three kinds of knowledge relate to the notions of epistemic subjectivity. These include: imaginative knowledge; reason, or knowledge from common notions; and intuitive knowledge. Imaginative knowledge works straightforwardly on the model of having ideas in the thick sense. (shrink)

Cognitive science normally takes the individual agent as its unit of analysis. In many human endeavors, however, the outcomes of interest are not determined entirely by the information processing properties of individuals. Nor can they be inferred from the properties of the individual agents, alone, no matter how detailed the knowledge of the properties of those individuals may be. In commercial aviation, for example, the successful completion of a flight is produced by a system that typically includes two or more (...) pilots interacting with each other and with a suite of technological devices. This article presents a theoretical framework that takes a distributed, socio‐technical system rather than an individual mind as its primary unit of analysis. This framework is explicitly cognitive in that it is concerned with how information is represented and how representations are transformed and propagated in the performance of tasks. An analysis of a memory task in the cockpit of a commercial airliner shows how the cognitive properties of such distributed systems can differ radically from the cognitive properties of the individuals who inhabit them. (shrink)

Everybody knows that humans are cultural animals. Although this fact is universally acknowledged, many opportunities to exploit it are overlooked. In this article, I propose shifting our attention from local examples of extended mind to the cultural-cognitive ecosystems within which human cognition is embedded. I conclude by offering a set of conjectures about the features of cultural-cognitive ecosystems.

Ethics on the Ark presents a passionate, multivocal discussion—among zoo professionals, activists, conservation biologists, and philosophers—about the future of zoos and aquariums, the treatment of animals in captivity, and the question of whether the individual, the species, or the ecosystem is the most important focus in conservation efforts. Contributors represent all sides of the issues. Moving from the fundamental to the practical, from biodiversity to population regulation, from animal research to captive breeding, Ethics on the Ark represents an important gathering (...) of the many fervent and contentious viewpoints shaping the wildlife conservation debate. (shrink)

His authority is always grounded in the very authority he deposes, with the result that his voice is little more than a theatrical performance that unwittingly re-enacts the rhetorical maneuvers of deposed father figures.

Explains the changing of seasons and describes how plants and animals adapt to and prepare for these changes.

A certain reading of Descartes, which we refer to as ‘the embodied Descartes’, is emerging from recent scholarship on L’Homme, in keeping with the interpretive trend which emphasizes Descartes’s identity as a natural philosopher. This reading complicates our understanding of Descartes’s philosophical project: far from strictly separating human minds from bodies, the embodied Descartes keeps them tightly integrated, while animal bodies behave in ways quite distinct from those of other pieces of extended substance. Here, we identify three categories of embodiment (...) in contemporary readings of Descartes’s physiology: bodily health and function, embodied reflex and memory, and embodied cognition. All present more or less strong versions of the embodied Descartes. Together, they constitute a compelling reading of a Cartesian natural philosophy that, if not expressly antidualist, is an awfully long way from the canonical picture. (shrink)

The author presents and defends three theses: (1) "the first is that it is not profitable for us at present to do moral philosophy; that should be laid aside at any rate until we have an adequate philosophy of psychology." (2) "the second is that the concepts of obligation, And duty... And of what is morally right and wrong, And of the moral sense of 'ought', Ought to be jettisoned if this is psychologically possible...." (3) "the third thesis is that (...) the differences between the well-Known english writers on moral philosophy from sidgwick to the present day are of little importance." (staff). (shrink)

I argue that Descartes is not a reductionist about life, but dissolves or eliminates the category entirely. This is surprising both because he repeatedly refers to the life of humans, animals, and plants and because he appears to rely on the category of life to construct his physiology and medicine. Various attempts have been made in the scholarship to attribute a principled concept of life to Descartes. Most recently, Detlefsen has argued that Descartes “is a reductionist with respect to explanation (...) of life phenomena but not an eliminativist with respect to life itself”. I show that all these attempts either result in arbitrariness or force Descartes's wider philosophical project into incoherence. I argue that Descartes's ontological commitments make a principled concept of life impossible, that he does not need such a concept, and that his project ends up more coherent without one. (shrink)

Graphical AbstractUnderstanding epigenetic modifications to chromatin that regulate gene expression and cell-fate decisions is now possible in single cells thanks to recent technological advances. As interdisciplinary approaches are required to derive biological principles, this workshop brought together some of Europe's leading researchers in single-cell epigenetics to share technologies and biological insights.

I argue that Descartes explains physiology in terms of whole systems, and not in terms of the size, shape and motion of tiny corpuscles (corpuscular mechanics). It is a standard, entrenched view that Descartes’ proper means of explanation in the natural world is through strict reduction to corpuscular mechanics. This view is bolstered by a handful of corpuscular–mechanical explanations in Descartes’ physics, which have been taken to be representative of his treatment of all natural phenomena. However, Descartes’ explanations of the (...) ‘principal parts’ of physiology do not follow the corpuscular–mechanical pattern. Des Chene has identified systems in Descartes’ account of physiology, but takes them ultimately to reduce down to the corpuscle level. I argue that they do not. Rather, Descartes maintains entire systems, with components selected from multiple levels of organization, in order to construct more complete explanations than corpuscular mechanics alone would allow. (shrink)

An introduction to the Great Books of the Western World series.

Two decades of attempts to model the emergence of language as a collective cognitive activity have demonstrated a number of principles that might have been part of the historical process that led to language. Several models have demonstrated the emergence of structure in a symbolic medium, but none has demonstrated the emergence of the capacity for symbolic representation. The current shift in cognitive science toward theoretical frameworks based on embodiment is already furnishing computational models with additional mechanisms relevant to the (...) emergence of symbolic language. An analysis of embodied interaction among captive, but not human‐enculturated, bonobo chimpanzees reveals a number of additional features of embodiment that are relevant to the emergence of symbolic language, but that have not yet been explored in computational simulation models; for example, complementarity of action in addition to imitation, iconic in addition to indexical gesture, coordination among multiple sensory and perceptual modalities, and the orchestration of intra‐ and inter‐individual motor coordination. The bonobos provide an evolutionarily plausible intermediate stage in the development of symbolic expression that can inform efforts to model the emergence of symbolic language. (shrink)

The field of Philosophy of Sport has been developing in Anglo-Saxon scholarship since the 1960s and since then has achieved considerable consolidation. However, this is a progressing field in Latin American countries like Brazil. This paper aims to analyse the trajectory of the Philosophy of Sport in Brazil, presenting an overview of its development since the 1980s and some prospects that have been generated since the turn of the century. In conclusion, the article points out that the field of Philosophy (...) of Sport in Brazil is in the process of disciplinary consolidation, presenting a plurality of agents, institutions and theoretical approaches in its structure. (shrink)

Derek Parfit’s view of personal identity raises questions about whether advance decisions refusing life-saving treatment should be honored in cases where a patient loses psychological continuity; it implies that these advance decisions would not be self-determining at all. However, rather than accepting that an unknown metaphysical ‘further fact’ underpins agential unity, one can accept Parfit’s view but offer a different account of what it implies morally. Part II of this article argues that contractual obligations provide a moral basis for honoring (...) advance decisions refusing life-saving and/or life-sustaining medical treatment; advance decisions have similarities to contracts, such as life insurance policies and will-contracts, that come into effect when the psychological discontinuity is through death. (shrink)

Neither the pathogenesis nor the aetiology of Down's syndrome (DS) are clearly understood. Numerous studies have examined whether clinical features of DS are a consequence of specific chromosome 21 segments being triplicated. There is no evidence, however, that individual loci are responsible, or that the oxidative damage in DS could be solely explained by a gene dosage effect. Using astrocytes and neuronal cultures from DS fetuses, a recent paper shows that altered metabolism of the amyloid precursor protein and oxidative stress (...) result from mitochondrial dysfunction.1 These findings are consistent with considerable data implicating the role of the mitochondrial genome in DS pathogenesis and aetiology. BioEssays 24:681–684, 2002. © 2002 Wiley Periodicals, Inc. (shrink)

Scientific research and ethics -- Ethical theory and decision making -- Data acquisition and management -- Mentoring and professional relationship -- Collaboration in research -- Authorship -- Publication and peer review -- Misconduct in research -- Intellectual property -- Conflicts of interest and scientific objectivity -- The use of animals in research -- The use of human subjects in research -- The use of vulnerable subjects in research -- Genetics, cloning, and stem cell research -- International research.

At various points in his work on physiology and medicine, Descartes refers to a “principle of life.” The exact term changes—sometimes, it is the “principle of movement and life”, sometimes the “principle underlying all [the] functions” of the body —but the message seems consistent: the phenomena of living bodies are the product of a single, underlying principle. That principle is generally taken to be cardiac heat.1 The literature has, quite reasonably, taken this message at face value. Thus, Shapiro: “Descartes insists (...) again and again that the human body is properly to be described as a machine whose workings are […] driven by the heat in the heart that... (shrink)

It is a commonly accepted view that men think to live, and do not live to think, that conation, and not cognition, is the primary object of living. Impression, affect, and expression constitute the complete psychic process. The term philosophy, the love of wisdom, also suggests that man's thought has a practical and not a theoretical objective. In this connection, however, two errors must be avoided: on the one hand an exaltation of the intellect as in rationalism, and on the (...) other hand a depreciation of the intellect as in pragmatism. (shrink)