ObjectiveLeveraging an integrative multimodal MRI paradigm to elaborate on the hippocampus-derived structural and functional changes in children and adolescents with juvenile idiopathic arthritis and to explore potential correlations within the “joint-inflammation-brain” axis during the period of central neural system development.MethodsTwenty-one patients with JIA all completed the multimodal MRI scanning, laboratory tests, and neuropsychological assessments; meanwhile, 23 matched controls were recruited. We then harnessed the spherical harmonics with a point distribution model and the ROI-to-voxel functional connectivity to measure the hippocampal shape (...) and hippocampo-cortical FC patterns. Correlation analysis was performed to explore the potential links in neuroimaging features with disease-related indices.ResultsCompared to controls, JIA patients only presented an atrophic tendency in the posterior part of the bilateral hippocampus. The hippocampo-cortical FC revealed the between-group divergences mainly located at the pain matrix, striatum, and temporal lobe. Remarkably, the enhanced FC between the right hippocampus and postcentral cortex is positively correlated with the disability index, while the weakened FC of right anterior hippocampus with right insula and that of left posterior hippocampus with left superior temporal gyrus was inversely related to the erythrocyte sedimentation rate and anxiety status, separately.ConclusionAs with macroscopic damages, the altered functional-connectome patterns of the hippocampus in JIA patients might be more sensitive to detect the early neuropathological changes. Moreover, the functional disturbances were demonstrated associated with the physical disability, inflammation, and emotional status. These findings may enlighten us on the underlying neuropathological mechanism of CNS comorbidities in JIA. (shrink)

Using private benefits of control and earnings management data from 41 countries and regions, we provide strong evidence that cultures, together with legal rules and law enforcement, play a critical role in shaping corporate behavior. More specifically, we find that private benefits of control are larger and earnings management is more severe in collectivist as opposed to individualist cultures, consistent with the argument that agency problems between corporate insiders and outside investors are severe in collectivist culture. These results are robust (...) to the inclusion of controls for country wealth, economic heterogeneity across countries, and international differences in ownership concentration. (shrink)

Having enjoyed remarkable economic success, China’s natural environment is being increasingly degraded, and with it, the quality of life. Researchers and environmentalists have responded by...

Under the framework of smart city, starting from the demand for urban public tourism information services, drawing on the new public service theory, customer perceived value theory, and basic information service theory, combined with previous research results, using literature analysis, questionnaire survey, and other methods, and starting from the carrier level of the public tourism information service system, this study analyzed the public tourism information services in detail. This study combed the current status quo and problems of the public tourism (...) information service system for qualitative analysis and summed up some common shortcomings and deficiencies. Along with the results of the questionnaire, this paper analyzed the existing problems in the current public tourism information service system and identified the demands of tourists for public tourism information services. Based on this, the research puts forward the idea of constructing the public tourism information service system under the background of smart city, including the system framework, characteristics, service media and mode, operation mode, management mechanism, and other aspects. The study concluded that there is a need to construct theoretical and research models of the impact of public tourism services on the quality of destination from the perspective of smart city, to use the structural equation model for quantitative analysis, to verify the model hypothesis, and to consider that public tourism services have a significant positive impact on the behavioral and psychological responses of tourists. On the basis of combing the literature and starting from the overall situation, this study puts forward a systematic integration idea, which is of theoretical significance. (shrink)

There has been a major international focus on the education and care of toddlers. To date, empirical studies on adults’ interactions in play with toddlers have focussed on the proximity of teachers, teachers’ affective responses, and joint attention between adults and children in play. However, less attention has been given to the role of two teachers working together in supporting children’s exploration of concepts in joint play. This paper takes a cultural-historical perspective and draws upon the concepts of play and (...) subjective positioning to investigate how co-teaching promotes toddlers’ joint play and exploration of mathematical concepts. Visual data of a group of toddlers playing with two teachers is analysed to explore how the teachers applied co-teaching pedagogy to support children’s exploration of mathematical concept. The study argues that co-teaching provides potential to support collective play as two teachers can work collaboratively to address the toddlers’ challenges and needs and support their exploration of the rules and mathematical concepts in play. Co-teaching by paired teachers enables toddlers’ joint play to become more complex, helping the children to explore mathematical concepts and, in turn, further enhancing their play. (shrink)

This paper presents the concept and algorithm of data mining and focuses on the linear regression algorithm. Based on the multiple linear regression algorithm, many factors affecting CET4 are analyzed. Ideas based on data mining, collecting history data and appropriate to transform, using statistical analysis techniques to the many factors influencing the CET-4 test were analyzed, and we have obtained the CET-4 test result and its influencing factors. It was found that the linear regression relationship between the degrees of fit (...) was relatively high. We further improve the algorithm and establish a partition-weighted K-nearest neighbor algorithm. The K-weighted K nearest neighbor algorithm and the partition algorithm are used in the CET-4 test score classification prediction, and the statistical method is used to study the relevant factors that affect the CET-4 test score, and screen classification is performed to predict when the comparison verification will pass. The weight K of the input feature and the adjacent feature are weighted, although the allocation algorithm of the adjacent classification effect has not been significantly improved, but the stability classification is better than K-nearest neighbor algorithm, its classification efficiency is greatly improved, classification time is greatly reduced, and classification efficiency is increased by 119%. In order to detect potential risk graduating students earlier, this paper proposes an appropriate and timely early warning and preschool K-nearest neighbor algorithm classification model. Taking test scores or make-up exams and re-learning as input features, the classification model can effectively predict ordinary students who have not graduated. (shrink)

Despite the dramatic traumas and enormous physical losses associated with many catastrophes, it is undeniable that catastrophes also function as dynamic powers that drive the development and transf...

In recent years, with the development of society and the rapid development of the animation industry, people are paying more and more attention to and requirements for animation production. As an indispensable part of animation production, picture composition plays a major role in animation production. It can give full play to the application of color matching and light and shadow design and enhance the depth and space of the animation screen. Tone space conversion refers to the conversion or representation of (...) color data in one color space into corresponding data in another color space. Its purpose is to distinguish and process color components such as hue and saturation in an image. This article first introduces the domestic and foreign research status of digital image preprocessing and analyzes the basic principles of several color space conversions in detail. Then, several color space conversion algorithms are studied, and the performance of the algorithms is compared and analyzed. The paper focuses on the hardware implementation and optimization of the algorithm for converting RGB color space into HSI color space to meet the real-time requirements. This article focuses on the mutual conversion between the RGB tone space and the HSI tone space and describes in detail how each color component in the HSI tone space is converted from the three RGB color components from a geometric perspective, and then the conversion is derived, and several general conversion methods of RGB to HSI tone space are introduced; two conversion methods of geometric derivation method and standard modulus algorithm are implemented in the software, and the comparison verification is carried out, and the comparison is made from the perspective of hardware implementation. The pros and cons of the two methods are discussed. Finally, the paper summarizes the shortcomings in the design and proposes further research directions in the future. (shrink)

Our paper draws attention to a neglected channel of corruption—the bribe payments by state-owned enterprises. This is an important phenomenon as bribe payments by SOEs fruitlessly waste national resources, compromising public welfare and national prosperity. Using a large dataset of 30,249 firms from 50 countries, we show that, in general, SOEs are less likely to pay bribes for achieving organizational objectives owing to their political connectivity. However, in deteriorated institutional environments, SOEs may be subjected to potential managerial rent-seeking behaviors, which (...) disproportionately increase SOE bribe propensity relative to privately owned enterprises. Specifically, our findings highlight the importance of fostering democracy and rule of law, reducing prevalence of corruption and shortening power distance in reducing the incidence of SOE bribery. (shrink)

This paper examined the relationship between coaches and youth athletes in China by comparing data collected before and after the lockdown. A total of 221 youth athletes aged 13-19 years in one professional football school completed coach-athlete relationship questionnaires. The rank-sum test was used to verify the differences in the data. The results of the Mann-Whitney U test showed that the mean value of the three dimensions of the coach-athlete relationship (closeness, commitment, and complementarity) increased after the COVID-19 lockdown. The (...) results also showed that athletes of different age categories showed different changes in the coach-athlete relationship after the lockdown, and the changes were not significantly related to the severity of the COVID-19 epidemic. The theoretical and practical implications are discussed. (shrink)

Does context influence our appreciation of beauty? To answer this question, two experiments were conducted to determine the effect of contextual aesthetics on the recognition of moral behavior. Experiment 1 demonstrated that individuals in a high-aesthetic context had a quicker recognition time for moral behavior than those in a low-aesthetic context. In a low-aesthetic context, individuals recognize immoral behavior more quickly than in a high aesthetic context. Individuals showed greater recognition rates for moral behavior in a high aesthetic context and (...) higher recognition for immoral behaviors in a low aesthetic context for behavior with unclear information. Experiment 2 revealed that individual fixation counts were smaller under the conditions of high aesthetic context and moral behavior than under the conditions of low aesthetic context and moral behavior, indicating a correlation between low aesthetic context and immoral behavior. This study shows that high aesthetic context facilitates the recognition of moral behavior, which has implications for moral education. (shrink)

Compared with the related western studies, Russian ecological philosophy has paid more attention to Eschatology and represented a unique path of thinking, that is, an intense rational conception and a religious consciousness. In the era of globalization, Russian ecological Eschatology, as an active response of Russian ideology to the world ecosystem crisis, contains a strong eschatological emotion and a spirit of salvation. It mainly deals with the sin and punishment between the nature and human being as well as the endeavor (...) of atoning humanity. The first part of the essay traces back the origin and evolution of eschatology and ecology in the two systems of Russian philosophy—humanism and cosmism, with a trimming of the original relationship between the ecological eschatology and the traditional eschatology. The second part explores the way of salvation for the human being in crisis directed by Russian ecological philosophy, which is nourished by the profound spiritual tradition. For the human being, the way of civilization lies in a rebuild of rationality by faith. The goal of faith is to achieve a self-completeness in morality by a heart-open through God. In this way, the destiny of the world may be changed. This is the only hope of the human being and, therefore, a new chapter of salvation for our times. (shrink)

Compensation rules for patent infringement greatly affect patent quality, which is closely related to R & D investments. In this study, A duopoly game model was developed to analyze innovative factories’ R&D investment and patent licensing behavior, as well as the strategic choices of potential infringers under different compensation rules for patent infringement. Furthermore, a comparative analysis was conducted to analyze the patent quality under different scenarios, ultimately finalizing an optimal sequence rule for patent infringement compensation. The results show that (...) patent quality is influenced by the invention height of patent and R&D efficiency, while the amount of patent infringement compensation has a great effect on potential infringement behavior. Patent quality can be effectively improved if the court adopts a proper sequence rule for patent infringement compensation according to the market circumstances. (shrink)

Liang Qichao was a leading political thinker and publicist. His manifesto, On the New People, was published serially in Japan, where Liang—like many other progressive intellectuals in the late Qing—lived and worked for a decade in order to avoid governmental suppression. The present essay was published in 1902 as part of On the New People. Liang began writing about rights as early as 1896; they came to occupy a prominent place in his theorizing after he arrived in (...) Japan in 1898. He was influenced by the Social Darwinist ideas of Kato Hiroyuki, which can be seen most clearly in Liang's 1899 essay "The Right of the Strongest." Although some of these ideas are still present in the current essay, Liang had by this time developed a more complex position, partly through reading and interpreting the ideas of Rudolph von Jhering , a pioneering German legal theorist whose influence on Liang was significant, as Liang himself declares early in this essay. (shrink)

Antibiotic resistance in bacteria has become a great threat to global public health. Tigecycline is a next‐generation tetracycline that is the final line of defense against severe infections by pan‐drug‐resistant bacterial pathogens. Unfortunately, this last‐resort antibiotic has been challenged by the recent emergence of the mobile Tet(X) orthologs that can confer high‐level tigecycline resistance. As it is reviewed here, these novel tetracycline destructases represent a growing threat to the next‐generation tetracyclines, and a basic framework for understanding the molecular epidemiology and (...) resistance mechanisms of them is presented. However, further large‐scale epidemiological and functional studies are urgently needed to better understand the prevalence and dissemination of these newly discovered Tet(X) orthologs among Gram‐negative bacteria in both human and veterinary medicine. (shrink)

ABSTRACT We show that there is a polynomial over the rational number field corresponding to each propositional formula in a given many-valued logic. To decide whether a propositional formula can be deduced from a finite set of such formulas (deduction problem), we only need to decide whether a polynomial vanishes on an algebraic variety. By using Wu's method, an algorithm for this problem is presented.

This is the first collection dedicated to presenting research directly influenced by the innovative and groundbreaking ideas of the eminent linguist Ruqaiya Hasan. The collection offers an insight into the breadth and depth of Hasan's distinctive linguistic approaches and theoretical concerns. The chapters cover areas such as verbal art, context of situation, semantic networks, cohesive harmony, text structure and literacy education, contributed by well-known scholars in the field such as M.A.K. Halliday, Geoffrey Williams, David Butt, Donna Miller, Wendy L. Bowcher, (...) Tom Bartlett and Margaret Berry. The volume contains an interview with Ruqaiya Hasan by David Butt and Jennifer Yameng Liang, and a section in which the contributors describe their connection and/or history with Ruqaiya Hasan and her work. This book is of particular value to scholars and students working in sociolinguistics, literary criticism, stylistics, functional linguistic theories, literacy pedagogy, social semiotics, multimodality and applied linguistics. (shrink)

The subject of the study is the works of contemporary St. Petersburg artists of different generations and creative trends, as well as the forms and features of their communication with each other and with the general as well as professional public. The trends of artistic communication in the city are determined by the activities of such institutions as art and non-art museums, art galleries and exhibition centers, which are a classic form of presentation of contemporary art; alternative venues such as (...) creative spaces and art clusters. The field of attention also includes the attraction of St. Petersburg authors to the organization of small artistic associations, mainly art groups, for example, "Unconquered", "North-7", "Parasites", etc. In addition to works of art, theoretical works and reflections by researchers of contemporary art in St. Petersburg and the spaces of its public presentation are involved. The methodological basis is the analysis of the works of St. Petersburg masters of the beginning of the XXI century in the context of the development of urban institutions of artistic communication. The research is based on theoretical works devoted to the problem of artistic communication and trends in the current art process. Comparative-interpretative and typological methods are used to compare the works of artists and forms of artistic communication. The problem of artistic communication in the field of fine art in St. Petersburg is becoming the subject of a separate study. This area of city life is currently developing quite dynamically, as new art associations, curatorial practices and alternative classical platforms for the presentation of the work of authors belonging to different generations and art movements are emerging. Traditional museums and galleries, as well as creative spaces, art clusters and other often non-core institutions, such as libraries and cafes, are involved in this process. Against this background, the features of St. Petersburg artistic communication crystallize, which is characterized by a desire to organize communities, to fuse realistic traditions and current trends, to escapism and symbolism, as well as an interest in oriental themes and stylistics. (shrink)

This paper proposes a nonlinear autoregressive neural network method for the investment performance evaluation of state-owned enterprises. It is different from the traditional method based on machine learning, such as linear regression, structural equation, clustering, and principal component analysis; this paper uses a regression prediction method to analyze investment efficiency. In this paper, we firstly analyze the relationship between diversified ownership reform, corporate debt leverage, and the investment efficiency of state-owned enterprises. Secondly, a set of investment efficiency evaluation index system (...) for SOE was constructed, and a nonlinear autoregressive neural network approach was used for verification. The data of A-share state-owned listed companies in Shanghai and Shenzhen stock exchanges from 2009 to 2018 are taken as a sample. The experimental results show that the output value from the NARNET is highly fitted to the actual data. Based on the neural network model regression analysis, this paper conducts a descriptive statistical analysis of the main variables and control variables of the evaluation indicators. It verifies the direct impact of diversified ownership reform on the investment efficiency of SOE and the indirect impact on the investment efficiency of SOE through corporate debt leverage. (shrink)

With the rapid development of artificial intelligence technology, multitasking textual translation has attracted more and more attention. Especially after the application of deep learning technology, the performance of multitask translation text detection and recognition has been greatly improved. However, because multitasking contains the interference problem faced by the translated text, there is a big gap between recognition performance and actual application requirements. Aiming at multitasking and translation text detection, this paper proposes a text localization method based on multichannel multiscale detection (...) of the largest stable extreme value region and cascade filtering. This paper selects the appropriate color channel and scale to extract the maximum stable extreme value area as the character candidate area and designs a cascaded filter from coarse to fine to remove false detections. The coarse filter is based on some simple morphological features and stroke width features, and the fine filter is trained by a two-recognition convolutional neural network. The remaining character candidate regions are merged into horizontal or multidirectional character strings through the graph model. The experimental results on the text data set prove the effectiveness of the improved deep learning network character model and the feasibility of the textual implication translation analysis method based on this model. Among them, the text contains translation character recognition results prove that the model has good description ability. The characteristics of the model determine that this method is not sensitive to the scale of the sliding window, so it performs better than the existing typical methods in retrieval tasks. (shrink)

Sydney Shoemaker, developing an idea of Wittgenstein’s, argues that we are immune to error through misidentification relative to the first-person pronoun. Although we might be liable to error when “I” (or its cognates) is used as an object, we are immune to error when “I” is used as a subject (as when one says, “I have a toothache”). Shoemaker claims that the relationship between “I” as-subject and the mental states of which it is introspectively aware is tautological: when, say, we (...) judge that “I feel pain,” we are tautologically aware that feels pain is instantiated and that it is instantiated in oneself. Moreover, he contends that this relationship holds not just for bodily sensations, but also for the sense of agency and for visual perception. But we deny that this relationship is tautological; instead, we treat Shoemaker’s principle (IEM) as a hypothesis. We then proceed to show that certain pathological states and experimentally-induced illusions can be adduced to show that IEM describes not a necessary relationship but a contingent relationship, one that sometimes fails to obtain. That we are not immune to error in the way Shoemaker describes has grave consequences for many aspects of his ideas concerning the first-person perspective. In the course of arguing that these empirical phenomena count against IEM, we also show that not only can the content of conscious experience be misrepresented, so too can the subject: that is, not only can the what of conscious experience be misrepresented, so too can the who. (shrink)

本书是文化哲学著述,对人类历史发展中的许多文化(精神)现象作了个性化的阐释,如人类开始为何要将自然神化,为何既需要上帝又需要尼采,为何后来又否定了神等问题。.

本书是文化哲学著述,对人类历史发展中的许多文化(精神)现象作了个性化的阐释,如人类开始为何要将自然神化,为何既需要上帝又需要尼采,为何后来又否定了神等问题。.

Based on the social network theory and the institutional theory, this study examines the influence of corporate network position on corporate social responsibility, and further explores the moderating role of ownership concentration. Given the characteristics of CSR in different aspects, this study explores the relationship between corporate network position and economic CSR, environmental CSR, and social CSR from the two aspects of the centrality and structural holes of interlocking directorate network based on the data of 1,034 Chinese A-share listed companies (...) from 2010 to 2019. The results show that the centrality and structural holes of interlocking directorate network have positive effects on the overall level of CSR, and the impacts on economic CSR and environmental CSR are stronger than that on social CSR. In addition, ownership concentration has a positive moderating effect on the relationship between corporate network position and CSR. These findings enrich the depth of research on CSR, clarify the influence of the characteristics of interlocking directorate network on CSR in different dimensions, and supplement the knowledge of existing research. (shrink)

The discovery of a stable latent reservoir for HIV‐1 in resting memory CD4+ T cells provides a mechanism for lifelong persistence of HIV‐1. The long‐lived latently infected cells persist in spite of prolonged highly active antiretroviral therapy and present a major barrier to a cure of HIV‐1 infection. In this review, we discuss the current understanding of HIV‐1 persistence and latent viral infection in the context of effective antiretroviral therapy and the recent progress in purging latent viral reservoirs. Recent studies (...) demonstrate that reactivation of latent HIV‐1 is a promising strategy for the depletion of these viral reservoirs. A thorough evaluation of the anti‐latency activity of drug candidates should include the measurement of changes in intracellular viral RNA, plasma virus levels, and the size of latent viral reservoirs, as well as potential adverse effects. Currently, there are several technical barriers to the evaluation of anti‐latency drugs in vivo. We also discuss these challenging issues that remain unresolved. (shrink)

Based on the challenge-hindrance stressor model, this study explored the mechanism of how challenge/hindrance demands affect cognitive wellbeing on a daily basis. Specifically, we examined the mediating effect of work–family enrichment on the relationship between challenge/hindrance demands and cognitive wellbeing. In addition, we tested the moderating effect of overqualification on the relationship between challenge/hindrance demands and work–family enrichment on a daily basis. Finally, we examined the moderated mediation effect of perceived overqualification in a multilevel model. To capture changes in work–family (...) enrichment and cognitive wellbeing that individuals perceived daily, the experience sampling method was adopted to test our theoretical models. A total of 99 participants from China were involved in this investigation. The results showed that daily challenge demands had a significant positive effect on daily cognitive wellbeing, and daily hindrance demands had a significant negative effect on wellbeing. In addition, daily work–family enrichment mediated the positive relationship between daily challenge demands and daily cognitive wellbeing. Moreover, perceived overqualification moderated the relationship between daily challenge demands and daily cognitive wellbeing in the multilevel model. Finally, a significant moderated mediating effect of this overqualification on the indirect effect of daily work–family enrichment on the relationship between daily challenge demands and daily cognitive wellbeing was observed. (shrink)