Background: We define compassion as an enduring disposition that centers upon empathetic concern for another person's suffering and the motivation to act to alleviate it. The contribution of specific candidate genes to the development of dispositional compassion for others is currently unknown. We examine candidate genes in the oxytocin and dopamine signaling pathways.Methods: In a 32-year follow-up of the Young Finns Study, we examined with multiple indicators latent growth curve modeling the molecular genetic underpinnings of dispositional compassion for others across (...) the life span. We selected five single nucleotide polymorphisms whose functions are known in humans: rs2268498, rs3796863, rs1800497, rs4680, and rs1611115. Compassion was measured with Cloninger's Temperament and Character Inventory on three repeated observations spanning 15 years. Differences between gender were tested.Results: We did not find an effect of the five SNPs in oxytocin and dopamine pathway genes on the initial levels of dispositional compassion for others. Individuals who carry one or two copies of the T-allele of DBH rs1611115, however, tend to increase faster in compassion over time than those homozygotes for the C-allele, b = 0.063. This effect was largely driven by male participants, 0.206, and was not significant in female participants when analyzed separately.Conclusions: Men who are known to have, on average, lower compassion than women seem to reduce this difference over time if they carry the T-allele of DBH rs1611115. The direction of the association indicates that dopamine signaling activity rather than overall dopamine levels might drive the development of compassion. (shrink)

This paper concerns non-causal normative explanations such as ‘This act is wrong because/in virtue of__’. The familiar intuition that normative facts aren't brute or ungrounded but anchored in non- normative facts seems to be in tension with the equally familiar idea that no normative fact can be fully explained in purely non- normative terms. I ask whether the tension could be resolved by treating the explanatory relation in normative explanations as the sort of ‘grounding’ relation that receives extensive discussion in (...) recent metaphysics. I argue that this would help only under controversial assumptions about the nature of normative facts, and perhaps not even then. I won't try to resolve the tension, but draw a distinction between two different sorts of normative explanations which helps to identify constraints on a resolution. One distinctive constraint on normative explanations in particular might be that they should be able to play a role in normative justification. (shrink)

[This paper is available as open access from the publisher.]The conventional wisdom in ethics is that pure moral laws are at least metaphysically necessary. By contrast, Moral Contingentism holds that pure moral laws are metaphysically contingent. This paper raises a normative objection to Moral Contingentism: it is worse equipped than Moral Necessitarianism to account for the normative standing or authority of the pure moral laws to govern the lives of the agents to whom they apply. Since morality is widely taken (...) to have such a standing, failing to account for it would be a significant problem. The objection also shows that the debate about the modal status of moral principles isn’t a debate solely within modal metaphysics, but has implications for topics in moral philosophy. (shrink)

Many philosophers believe that the extensions of evaluative terms and concepts aren’t unified under non-evaluative similarity relations and that this “shapelessness thesis” (ST) has significant metaethical implications regarding non-cognitivism, ethical naturalism, moral particularism, thick concepts and more. ST is typically offered as an explanation of why evaluative classifications appear to “outrun” classifications specifiable in independently intelligible non-evaluative terms. This paper argues that both ST and the outrunning point used to motivate it can be explained on the basis of more general (...) factors that have nothing in particular to do with being evaluative. If so, there is no reason to expect ST to carry the sorts of metaethical implications that get attributed to it. I also show that my main argument is robust across certain complications that are raised by the context-sensitivity of many evaluative terms but have so far been ignored in discussions of ST and related matters. (shrink)

This paper is a survey of the generalism-particularism debate in ethics.

[This paper is available as open access from the publisher.] Normative theories aim to explain why things have the normative features they have. This paper argues that, contrary to some plausible existing views, one important kind of normative explanations which first-order normative theories aim to formulate and defend can fail to transmit downward along chains of metaphysical determination of normative facts by non-normative facts. Normative explanation is plausibly subject to a kind of a justification condition whose satisfaction may fail to (...) transmit along the relevant kind of metaphysical hierarchy. A broader aim of the paper is to contribute to systematic theorizing about normative explanation: whereas there has been a great deal of work on scientific explanation, there has been little by way of systematic exploration of what sort of explanations normative theories aim to formulate and defend. (shrink)

This paper is a survey of the generalism-particularism debate and related issues concerning the relationship between normative reasons and moral principles.

The present article discusses the concept of synderesis in the late medieval universities of Erfurt and Leipzig and the later developments in Wittenberg. The comparison between Bartholomaeus Arnoldi of Usingen in Erfurt and Johannes Peyligk in Leipzig shows that school traditions played an important role in the exposition of synderesis by the late medieval scholastic natural philosophers. However, Jodocus Trutfetter's example warns against overemphasizing the importance of the school traditions and reminds us of the manifold history of medieval discussions on (...) synderesis, which were more or less familiar to many authors of this period. Finally, the diverse references to synderesis in the texts of Martin Luther, Johannes Bernhardi of Feldkirch and Philip Melanchthon reveal no uniform relationship with late medieval discussions but rather indicate various ways of adopting scholastic ideas and transforming them in the context of humanist and reformation thinking. (shrink)

This paper is a survey of the generalism-particularism debate in ethics. It's an updated version of "Moral Particularism", in Christian B. Miller (ed.), The Continuum Companion to Ethics (Continuum, 2011), pp. 247-260.

Philosophers often claim that forgiveness is a paradoxical phenomenon. I here examine two of the most widespread ways of dealing with the paradoxical nature of forgiveness. One of these ways, emblematized by Aurel Kolnai, seeks to resolve the paradox by appealing to the idea of repentance. Somehow, if a wrongdoer repents, then forgiving her is no longer paradoxical. I argue that this influential position faces more problems than it solves. The other way to approach the paradox, exemplified here by the (...) work of Jacques Derrida, is just too obscure to be by itself helpful. Yet, I argue that what I take to be its spirit is on the right track. I recommend distinguishing between the definition and the justification of forgiveness, and also between forgiveness understood as a mental phenomenon and an overt, communicative act. These distinctions are not given their due in the specialized literature, and I expose the nefarious consequences of this neglect. By focusing on forgiveness as a mental phenomenon I seek to analyze the root of the talk of paradoxes which surrounds the discussion of forgiveness. Finally, I present an analysis of forgiveness as a pure mental phenomenon, and argue that this analysis is the most important step in understanding forgiveness in any other sense. While my analysis reveals interesting aspects of forgiveness, it reveals, too, that forgiveness is not quite as paradoxical after all. (shrink)

So-called "thick" moral concepts are distinctive in that they somehow "hold together" evaluation and description. But how? This paper argues against the standard view that the evaluations which thick concepts may be used to convey belong to sense or semantic content. That view cannot explain linguistic data concerning how thick concepts behave in a distinctive type of disagreements and denials which arise when one speaker regards another's thick concept as "objectionable" in a certain sense. The paper also briefly considers contextualist, (...) presuppositional, and implicature accounts of the evaluative contents of thick concepts, but finds none clearly superior to the others. (shrink)

Normative explanations, which specify why things have the normative features they do, are ubiquitous in normative theory and ordinary thought. But there is much less work on normative explanation than on scientific or metaphysical explanation. Skow (2016) argues that a complete answer to the question why some fact Q occurs consists in all of the reasons why Q occurs. This paper explores this theory as a case study of a general theory that promises to offer us a grip on normative (...) explanation which is independent of particular normative theories. I first argue that the theory doesn’t give an adequate account of certain enablers of reasons which are important in normative explanation. I then formulate and reject three responses on behalf of the theory. But I suggest that since theories of this general sort have the right kind of resources to illuminate how normative explanation might be similar to and different from explanations in other domains, they nonetheless merit further exploration by normative theorists. (shrink)

Over the past few decades, Indigenous communities have successfully campaigned for greater inclusion in decision-making processes that directly affect their lands and livelihoods. As a result, two important participatory rights for Indigenous peoples have now been widely recognized: the right to consultation and the right to free, prior and informed consent (FPIC). Although these participatory rights are meant to empower the speech of these communities—to give them a proper say in the decisions that most affect them—we argue that the way (...) these rights have been implemented and interpreted sometimes has the opposite effect, of denying them a say or ‘silencing’ them. In support of this conclusion we draw on feminist speech act theory to identify practices of locutionary, illocutionary, and perlocutionary group silencing that arise in the context of consultation with Indigenous communities. (shrink)

Maude's excellent translation of Tolstoy's treatise on the emotionalist theory of art was the first unexpurgated version of the work to appear in any language. More than ninety years later this work remains, as Vincent Tomas observed, "one of the most rigorous attacks on formalism and on the doctrine of art for art's sake ever written". Tomas' Introduction makes this the edition of choice for students of aesthetics and anyone with philosophical interests.

This paper defends doubts about the existence of genuine moral perception, understood as the claim that at least some moral properties figure in the contents of perceptual experience. Standard examples of moral perception are better explained as transitions in thought whose degree of psychological immediacy varies with how readily non-moral perceptual inputs, jointly with the subject's background moral beliefs, training, and habituation, trigger the kinds of phenomenological responses that moral agents are normally disposed to have when they represent things as (...) being morally a certain way. (shrink)

Offering an innovative approach to critical thinking, Good Reasoning Matters! identifies the essential structure of good arguments in a variety of contexts and also provides guidelines to help students construct their own effective arguments. In addition to examining the most common features of faulty reasoning--slanting, bias, propaganda, vagueness, ambiguity, and a common failure to consider opposing points of view--the book introduces a variety of argument schemes and rhetorical techniques. This edition adds material on visual arguments and more exercises.

In the paper ‘COVID-19 vaccine boosters for young adults: a risk–benefit assessment and ethical analysis of mandate policies at universities,’ Bardoshet alargued that college mandates of the COVID-19 booster vaccine are unethical. The authors came to this conclusion by performing three different sets of comparisons of benefits versus risks using referenced data and argued that the harm outweighs the risk in all three cases. In this response article, we argue that the authors frame their arguments by comparing values that are (...) not scientifically or reasonably comparable and that the authors used values that represent grossly different risk profiles and grouped them into a set of figures to create an illusion of fair comparisons. We argue that absent the falsely skewed portrayals of a higher level of risk over benefit in their misrepresented figures, the five ethical arguments they presented completely fall apart. (shrink)

The accommodation of evidence has been argued to be associated with several methodological problems that should prompt evaluators to lower their confidence in the accommodative theory. Accommodators may overfit their model to data (Hitchcock and Sober, Br J Philos Sci 55(1):1–34, 2004. https://doi.org/10.1093/bjps/55.1.1), hunt for (spurious) associations between variables (Mayo, Error and the growth of experimental knowledge. University of Chicago Press, Chicago, 1996, pp 294–318), or ‘fudge’ their theory in the effort to accommodate a particular datum (Lipton, Inference to the (...) best explanation. Routledge, London, 2004, pp. 164–183). The converse of accommodation, novel prediction, has been offered as a solution. If theorists novelly predict empirical results rather than accommodate those results, the potential risks of accommodation are avoided, and the theory warrants greater confidence. This paper evaluates if the problems of accommodation justify a preference for novel prediction over accommodation for evaluators of a scientific theory. I argue that there is currently insufficient evidence to conclude that the problems of accommodation result in a predictivist advantage in theory confirmation. Taking into consideration the disadvantages of novel prediction and the advantages of accommodation, the impact of further evidential factors, and recent scientific evidence about the consequences of novel prediction and accommodation, novel prediction and accommodation appear roughly on a par, or accommodation is even superior in the current context. (shrink)

The dimensional structure of phenomenal space and its relation to the brain have not been widely focused on in brain and consciousness studies. This paper postulates that focusing on the dimensional structures displayed in the relation between phenomenal space and the brain is necessary for understanding the integration of distributed brain events in binding. A related issue is why items and events of phenomenal space and consciousness as they appear in experience seem to be beyond the reach of natural scientific (...) empirical observation. The proposed solution to these issues is postulated to require a fourth spatial dimension. A transcendence principle of detection (TPD) is introduced, which states that transcendent degrees of freedom of an n+1 dimension are a necessary condition for experiencing or detecting an n-dimensionally extended physical structure as an n-dimensionally extended phenomenal structure. It is postulated that the phenomenal outcome of binding, i.e. the threedimensionally distributed and extended phenomenal structure of human experience, is the expected first-person outcome of threedimensionally distributed neurophysical structures being monitored at the domain of a fourth spatial dimension. (shrink)

In this paper, I explore what gives collective testimony its epistemic credentials, through a critical discussion of three competing accounts of the epistemology of collective testimony. According to the first view, collective testimony inherits its epistemic credentials from the beliefs the testimony expresses— where this can be seen either as the beliefs of all or some of the group’s members, or as the beliefs of group itself. The second view denies any necessary connection to belief, claiming instead that the epistemic (...) credentials of collective testimony derive from the reliability or truth-conduciveness of the statement that expresses the testimony. Finally, the third view claims that the epistemic credentials of collective testimony derive from the fact that it involves undertaking a collective commitment to trustworthiness, which makes the group susceptible to rebuke and blame if its testimony is not trustworthy. I argue that this last account holds the most promise for preserving what is distinctive about testimonial knowledge while still underwriting a robust epistemology of collective testimony. (shrink)

“Whatever matters to human beings, trust is the atmosphere in which it thrives” writes Sissela Bok. Although trust is ubiquitous, understanding trust is a non-trivial challenge. Trust: Analytic and Applied Perspectives addresses critical and analytical issues of trust. It examines trust from a conceptual perspective as well as considers it in practical contexts ranging from the public sphere broadly understood to particular social institutions, such as universities and medical care. Trust: Analytic and Applied Perspectives explores what kind of good trust (...) is, what kind of goods it can protect and how it can bring about goods, and develops subtle distinctions between trust and other virtues, and between trust and other forms of dependence.The pluralism of the volume reflects the diversity of the real world contexts and theoretical perspectives indispensable in the search of a deeper understanding of trust. Without such an understanding of the nature of trust and the good reasons why people might trust one another or the institutions, we are in danger of designing institutions that will reduce trust or even drive it out. Trust: Analytic and Applied Perspectives sheds new light on the intersecting dimensions of our social cooperation, in which trust can be responsibly undertaken. (shrink)

Social theory, the theory of social action, and social sciences.

Leo Strauss articulates the conflict between reason and revelation as he explores Spinoza's scientific, comparative, and textual treatment of the Bible. Strauss compares Spinoza's Theologico-political Treatise and the Epistles, showing their relation to critical controversy on religion from Epicurus and Lucretius through Uriel da Costa and Isaac Peyrere to Thomas Hobbes. Strauss's autobiographical Preface, traces his dilemmas as a young liberal intellectual in Germany during the Weimar Republic, as a scholar in exile, and as a leader of American philosophical thought. (...) "[For] those interested in Strauss the political philosopher, and also those who doubt whether we have achieved the 'final solution' in respect to either the character of political science or the problem of the relation of religion to the state." -- Journal of Politics "A substantial contribution to the thinking of all those interested in the ageless problems of faith, revelation, and reason." -- Kirkus Reviews Leo Strauss (1899-1973) was the Robert Maynard Hutchins Distinguished Service Professor Emeritus of political science at the University of Chicago. His contributions to political science include The Political Philosophy of Hobbes, The City and the Man, What is Political Philosophy?, and Liberalism Ancient and Modern. (shrink)

According Philip Pettit, suitably organised groups not only possess ‘minds of their own’ but can also ‘make up their minds’ and 'speak for themselves'--where these two capacities enable them to perform as conversable subjects or 'persons'. In this paper I critically examine Pettit's case for group personhood. My first step is to reconstruct his account, explaining first how he understands the two capacities he considers central to personhood – the capacity to ‘make up one’s mind’, and the capacity to ‘speak (...) for oneself’ – before showing how he thinks these can be manifested in groups. With Pettit’s account duly reconstructed, I then turn to criticism, arguing that Pettit’s construal of making up one’s mind does not do proper justice to our first-personal self-understanding, nor to our characteristic interpersonal forms of engagement. This leads me, finally, to consider an alternative construal of ‘making up one’s mind’ and ‘speaking for oneself’ that is associated with the work of Richard Moran and whichargue, could usefully be exteextended to groups. (shrink)

X‐linked agammaglobulinemia is a heritable immunodeficiency disease caused by a differentiation abnormality, resulting in the virtual absence of B Iymphocytes and plasma cells. The affected gene encodes a cytoplasmic protein tyrosine kinase, Bruton's agammaglobulinemia tyrosine kinase, designated Btk. Btk and the other family members, Tec, Itk and Bmx, contain five regions, four of which are common structural and functional modules that are found in other signaling proteins. Mutations affect all domains of the gene, but amino acid substitutions seem to be (...) confined to certain regions. More than 150 unique mutations have been identified and are collected in a mutation database, BTKbase. Here we discuss the three‐dimensional structural implications of such mutations and their putative functional role. Of special interest are mutations affecting the pleckstrin homology domain, as Btk is the only disease‐associated protein so far reported to carry mutations in this particular module. (shrink)

This paper is a survey of the supervenience challenge to non-naturalist moral realism. I formulate a version of the challenge, consider the most promising non-naturalist replies to it, and suggest that no fully effective reply has yet been given.

Corporate social responsibility (CSR) has been recently conceptualized and studied as a political phenomenon. Most debates in this scholarship have thus far focused on normative issues. Less attention has been paid to the explanatory potential of CSR research grounded in political theory and philosophy. In this article, we conduct a pragmatist reading of political scholarship on CSR and seek to deploy existing knowledge for research pursuing political explanation. We argue that the political ontologies that underlie scholarship on CSR can be (...) used to transform normative and descriptive research also for explanatory uses. We show how ontologies vary in terms of potential research objects and scopes of political explanation, and argue that the main types of political-ontological stances adopted in scholarship on CSR, foundational and post-foundational stances, offer explanatory analysis of different schematic guidelines. Our pragmatist reading of previous research and an empirical case illustration of political explanation of change in corporate responsibility in the biofuel industry demonstrate the opportunities, limitations, and challenges different political-ontological commitments provide for political explanation. (shrink)

[First published 09/2016; substantive revision 02/2021.] Evaluative terms and concepts are often divided into “thin” and “thick”. We don’t evaluate actions and persons merely as good or bad, or right or wrong, but also as kind, courageous, tactful, selfish, boorish, and cruel. The latter evaluative concepts are "descriptively thick": their application somehow involves both evaluation and a substantial amount of non-evaluative description. This article surveys various attempts to answer four fundamental questions about thick terms and concepts. (1) A “combination question”: (...) how exactly do thick terms and concepts relate evaluation and non-evaluative description? (2) A “location question”: is evaluation somehow inherent to thick terms and concepts, such as perhaps an aspect of their meaning, or merely a feature of their use? (3) A “delineation question”: how do thick terms differ from the thin and from other kinds of evaluative terms? (4) Given answers to these questions, what broader philosophical significance and applications might thick concepts have? (shrink)

This paper offers a general model of substantive moral principles as a kind of hedged moral principles that can (but don't have to) tolerate exceptions. I argue that the kind of principles I defend provide an account of what would make an exception to them permissible. I also argue that these principles are nonetheless robustly explanatory with respect to a variety of moral facts; that they make sense of error, uncertainty, and disagreement concerning moral principles and their implications; and that (...) one can grasp these principles without having to grasp any particular list of their permissibly exceptional instances. I conclude by pointing out various advantages that this model of principles has over several of its rivals. The bottom line is that we should find nothing peculiarly odd or problematic about the idea of exception-tolerating and yet robustly explanatory moral principles. (shrink)

Francesco Guala has written an important book proposing a new account of social institutions and criticizing existing ones. We focus on Guala’s critique of collective acceptance theories of institutions, widely discussed in the literature of collective intentionality. Guala argues that at least some of the collective acceptance theories commit their proponents to antinaturalist methodology of social science. What is at stake here is what kind of philosophizing is relevant for the social sciences. We argue that a Searlean version of collective (...) acceptance theory can be defended against Guala’s critique and question the sufficiency of Guala’s account of the ontology of the social world. (shrink)

Maude's excellent translation of Tolstoy's treatise on the emotionalist theory of art was the first unexpurgated version of the work to appear in any language. More than ninety years later this work remains, as Vincent Tomas observed, "one of the most rigorous attacks on formalism and on the doctrine of art for art's sake ever written". Tomas' Introduction makes this the edition of choice for students of aesthetics and anyone with philosophical interests.

A reissue of the 1975 edition, with four added essays, this collection offers a clear introduction to Strauss' views regarding the nature of political ...

The aim of the present study was to explore the use and understanding of the concepts ‘placebo’ and ‘placebo effect’ in 12 empirical studies that have addressed the prescription of placebos by doctors in clinical practice. There were great differences in the general methodology and in the definitions (or lack of any definition) of the basic concepts in these 12 studies. Therefore, the results reflect different things. They tell us a little about the use of ‘pure placebos’, more about the (...) use of ‘impure placebos’, but most of all, they tell us about the conceptual confusion in this area. (shrink)

A particular tradition in medicine claims that a variety of evidence is helpful in determining whether an observed correlation is causal. In line with this tradition, it has been claimed that establishing a causal claim in medicine requires both probabilistic and mechanistic evidence. This claim has been put forward by Federica Russo and Jon Williamson. As a result, it is sometimes called the Russo–Williamson thesis. In support of this thesis, Russo and Williamson appeal to the practice of the International Agency (...) for Research on Cancer. However, this practice presents some problematic cases for the Russo–Williamson thesis. One response to such cases is to argue in favour of reforming these practices. In this paper, we propose an alternative response according to which such cases are in fact consistent with the Russo–Williamson thesis. This response requires maintaining that there is a role for mechanism-based extrapolation in the practice of the IARC. However, the response works only if this mechanism-based extrapolation is reliable, and some have argued against the reliability of mechanism-based extrapolation. Against this, we provide some reasons for believing that reliable mechanism-based extrapolation is going on in the practice of the IARC. The reasons are provided by appealing to the role of robustness analysis. (shrink)

I defend moral generalism against particularism. Particularism, as I understand it, is the negation of the generalist view that particular moral facts depend on the existence of a comprehensive set of true moral principles. Particularists typically present "the holism of reasons" as powerful support for their view. While many generalists accept that holism supports particularism but dispute holism, I argue that generalism accommodates holism. The centerpiece of my strategy is a novel model of moral principles as a kind of "hedged" (...) principles that incorporate an independently plausible "basis thesis" concerning the explanation of moral reasons. The model implies that moral reasons requires the existence of a comprehensive set of true hedged principles, and so it captures generalism. But the model also offers an alternative explanation of holism, and so it undercuts much of the motivation for particularism. I defend this moderate (because holism-tolerating) form of generalism against a number of objections, and show how it can be used to defeat three distinct arguments from holism to particularism. (shrink)

This paper offers a simple response to the Moral Twin Earth (MTE) objection to Naturalist Moral Realism (NMR). NMR typically relies on an externalist metasemantics such as a causal theory of reference. The MTE objection is that such a theory predicts that terms like ‘good’ and ‘right’ have a different reference in certain twin communities where it’s intuitively clear that the twins are talking about the same thing when using ‘good’. I argue that Boyd’s causal regulation theory, the original target (...) of the MTE objection, was never vulnerable to this objection. The theory contains an epistemic constraint on reference which implies that either the property that causally regulates uses of ‘good’ isn’t different for the twin communities or, in scenarios where the reference is different, the communities diverge in ways where it’s not intuitively clear that ‘good’ has the same reference for them. (shrink)

Recent feminist philosophy of language has highlighted the ways that the speech of women can be unjustly impeded, because of the way their gender affects the uptake their speech receives. In this chapter, I explore how similar processes can undermine the speech of a different sort of speaker: Indigenous communities. This involves focusing on Indigeneity rather than gender as the salient social identity, and looking at the ways that group speech, rather than only individual speech, can be unjustly impeded. To (...) do this, I make use of the notion of ‘discursive injustice’ that has been developed by Quill Kukla, and, with reference to three case studies, show how discursive injustice can effectively derail the speech of Indigenous communities. (shrink)