Establishment of cell lineage identity from multipotent progenitors is controlled by cooperative actions of lineage‐specific and stably expressed transcription factors, combined with input from environmental signals. Lineage‐specific master transcription factors activate and repress gene expression by recruiting consistently expressed transcription factors and chromatin modifiers to their target loci. Recent technical advances in genome‐wide and multi‐omics analysis have shed light on unexpected mechanisms that underlie more complicated actions of transcription factors in cell fate decisions. In this review, we discuss functional dynamics (...) of stably expressed and continuously required factors, Notch and Runx family members, throughout developmental stages of early T cell development in the thymus. Pre‐ and post‐commitment stage‐specific transcription factors induce dynamic redeployment of Notch and Runx binding genomic regions. Thus, together with stage‐specific transcription factors, shared transcription factors across distinct developmental stages regulate acquisition of T lineage identity. (shrink)

Razón, poesía, historia.--La cuestión del estoicismo español.--El querer.

Dibujar el pensamiento de Seneca es dibujar su figura viva, trazar el esquema de su persona. Seneca es un mediador que para alzarse sobre nosotros necesita de nuestra necesidad, pues solo apoyado en nuestra indigencia tiene sentido. Maria Zambrano lleva a cabo un lucido estudio de la figura y significacion del pensador cordobes y presenta una seleccion de sus escritos.

Hilary Putnam is one of the world’s leading philosophers. His highly original and often provocative ideas have set the agenda for a variety of debates in philosophy of science, philosophy of mind and philosophy of language. His now famous philosophical thought experiments, such as the ‘Twin earth’ and ‘the brains in the vat’ have become part of the established canon in philosophy and cognitive science. _Reading Putnam_ is an outstanding overview and assessment of Hilary Putnam’s work by a team of (...) international contributors, and includes replies by Putnam himself. Divided into clear sections, it contains chapters on key aspects of Putnam’s large body of writing, including: Scientific realism and the changes that Putnam’s thought has undergone on this topic analyticity and ontology, including the important interconnections between the views of Putnam and Quine Putnam’s arguments concerning externalist views of meaning and reference, questions of conceptual relativity, and his preoccupation with ethics through a denial of the fact–value dichotomy Putnam’s developing views on perception. Offering an excellent survey of Putnam’s work, _Reading Putnam_ is essential for those studying philosophy of mind, philosophy of language, and philosophy of science, as well as for anyone interested in contemporary philosophy. (shrink)

生命科学、医学、社会学、経済学、そして、政治学。あらゆる知の最新の達成を渉猟し、法・政治・制度といった現実の問題を真正面から考え続けてきた哲学者が、研ぎ澄まされた言葉で「生」を描きだす。.

This article describes a number of human cohort studies based on the concept of brain‐science and education. These studies assess the potential effects of new technologies on babies, children and adolescents, and test hypotheses drawn from animal and genetic case studies to see if they apply to people. A flood of information, virtual media, individualism and the pursuit of efficiency might be transforming our brain and its functions. An environmental assessment from the metaphysical aspect could be essential to providing an (...) appropriate environment for future generations. (shrink)

In ‘Causes and Reasons of Desert Islands’, Gilles Deleuze presents a mythological and scientific vision in which new islands and new humanity emerge from the opposition between the land and sea in desert islands. However, what Deleuze cannot explain is how such new territory and people are produced and reproduced while rejecting old and conventional generational ways. To break this impasse, which is also present in Difference and Repetition, Deleuze and Guattari intend to retain the absolute movement of deterritorialisation, while (...) acknowledging that deterritorialisation and reterritorialisation always comingle. This theoretical project is found in the critique of Pierre Clastres on counter-state societies, and is taken up by Deleuze and Guattari in What is Philosophy? In this latter work, by creating concepts and constituting a new plane, Deleuze and Guattari offer some conditions of a third reterritorialisation that, after the second reterritorialisation in the democratic states, presents a new way of forging a political and revolutionary philosophy. In this essay, we criticise the opinions that consider Deleuze and Guattari's political philosophy as one version of radical democracy. Their political philosophy should be situated in the post-democratic era to come. (shrink)

Abstract When the Meiji government allowed Christianity to be proclaimed in Japan in 1873, there aroused heated controversy about how to deal with religion including Christianity. Fukuzawa Yukichi, the most influential thinker and opinion?leader among Japanese intellectuals in those days, participated in the controversy and wrote more than 80 articles concerning religion. At first, he took a critical standpoint against Christianity from the Utilitarian viewpoint. Then he changed his viewpoint of religion and came to admit a Unitarian Christianity for a (...) little while. But he gradually came to be familiar with Pure Land Buddhism and developed his original phibsophy of religion in his later years. In this article I trace the process of change in Fukuzawa's religious viewpoint and clarify his philosophy of religion in his later years, by examining his writings in chronological order. (shrink)

This paper compares two case studies of prepaid card technology where the same ``technology'' is applied in two separate industries, the public telephone industry and the pachinko game industry in Japan. The different outcomes in the two areas are analyzed in terms of the functions of what is introduced here as ``socio-technological aggregates''. A socio-technological aggregate is composed of an initiating innovator component and heterogeneous components necessary for the technology to function in a given society. The analysis of technology as (...) an STA gained insights from the phenomena of aggregates in other areas: the socio-literary aggregate created by Russell McCormmach in Night Thoughts of a Classical Physicist; by the ``collage'' phenomenon created by Picasso, Braque; and others, and the socio-musical aggregates of John Cage. Two important aspects of an STA are: the bonding/managing component that dictates how a technology is applied; and the evaluator component that triggers multimodality. (shrink)

In classifications of vocabulary knowledge, vocabulary size and depth have often been separately conceptualized (Schmitt, 2014). Although size and depth are known to be substantially correlated, it is not clear whether they are a single construct or two separate components of vocabulary knowledge (Yanagisawa & Webb, 2020). This issue has not been addressed extensively in the literature and can be better examined using structural equation modeling (SEM), with measurement error modeled separately from the construct of interest. The current study reports (...) on conventional and Bayesian SEM approaches (e.g., Muthén & Asparouhov, 2012) to examine the factor structure of the size and depth of second language vocabulary knowledge of Japanese adult learners of English. A total of 255 participants took five vocabulary tests. One test was designed to measure vocabulary size in terms of the number of words known, while the remaining four were designed to measure vocabulary depth in terms of word association, polysemy, and collocation. All tests used a multiple-choice format. The size test was divided into three subtests according to word frequency. Results from conventional and Bayesian SEM show that a correlated two-factor model of size and depth with three and four indicators, respectively, fit better than a single-factor model of size and depth. In the two-factor model, vocabulary size and depth were strongly correlated (r =.945 for conventional SEM and.943 for Bayesian SEM with cross loadings), but they were distinct. The implications of these findings are discussed. (shrink)

Drawing on recent findings, this study examines whether valence concordant electromyography (EMG) responses can be explained as an unconditional effect of mere stimulus processing or as somatosensory simulation driven by task-dependent processing strategies. While facial EMG over the Corrugator supercilii and the Zygomaticus major was measured, each participant performed two tasks with pictures of album covers. One task was an affective evaluation task and the other was to attribute the album covers to one of five decades. The Embodied Emotion Account (...) predicts that valence concordant EMG is more likely to occur if the task necessitates a somatosensory simulation of the evaluative meaning of stimuli. Results support this prediction with regard to Corrugator supercilii in that valence concordant EMG activity was only present in the affective evaluation task but not in the non-evaluative task. Results for the Zygomaticus major were ambiguous. Our findings are in line with the view that EMG activity is an embodied part of the evaluation process and not a mere physical outcome. (shrink)

_Jane and Louise Wilson_ With Essays by Jeremy Millar and Claire Doherty London: Ellipsis, 2000 ISBN 1-84166-027-2 84 pp., inc. 120 b/w photograph.

The coloniality of power is understood by Anibal Quijano as at the constituting crux of the global capitalist system of power. What is characteristic of global, Eurocentered, capitalist power is that it is organized around two axes that Quijano terms “the coloniality of power” and “modernity.” The coloniality of power introduces the basic and universal social classification of the population of the planet in terms of the idea of race, a replacing of relations of superiority and inferiority established through domination (...) with naturalized understandings of inferiority and superiority. In this essay, Lugones introduces a systemic understanding of gender constituted by colonial/modernity in terms of multiple relations of power. This gender system has a light and a dark side that depict relations, and beings in relation as deeply different and thus as calling for very different patterns of violent abuse. Lugones argues that gender itself is a colonial introduction, a violent introduction consistently and contemporarily used to destroy peoples, cosmologies, and communities as the building ground of the “civilized” West. (shrink)

Scholars have long been intrigued by the Buddha's defining action (karma) as intention. This book explores systematically how intention, agency, and moral psychology were interpreted in all branches of early Theravada thought, paying special attention to the thought of the 5th-century commentator Buddhaghosa.