The ancient Chinese text the Zhuangzi raises a mix of epistemological, psychological, and conceptual challenges against the value and usefulness of philosophical disputation. But instead of advocating the elimination of philosophy, it implicitly embraces a broader conception of philosophy, the goal of which is to engage us to reflect on our limitations, question things we take for granted, and better appreciate alternative perspectives and possibilities. Philosophy thus understood is compatible with a variety of methods and approaches: fictions, jokes, paradoxes, spiritual (...) exercises, argument, disputation, and so on. Philosophical practices, on this view, also pave the way for an open‐minded, adaptive and flexible way of living that is at the core of the Zhuangist good life. (shrink)

While respect for persons is fundamental to many moral and political theories, its nature and ground remain controversial. According to the standard model of respect, respect is primarily a response to certain inherent features of a person or an object. Importantly, it is in virtue of the value, status or authority of those features that respect is justified or owed. This model, however, faces many serious challenges. Drawing on the classical Confucian notion of jing, I develop an alternative model of (...) respect, which construes respect as an expression of agent’s sense of the self and its place in the world. The emphasis is thus on the agent’s own self-conception and the corresponding attitudes and dispositions, as opposed to on inherent features of the objects of respect. To further illustrate this distinction, I contrast the traditional Kantian conception of respect for persons with the Confucian, jing-based, conception along three dimensions: the normative ground, the content, and the distribution of respect. The Kantian respect certainly has its merits, and perhaps is indispensable in some contexts, but there is much more to respect than what Kantians can offer. The Confucian conception of respect, on the other hand, has important theoretical and practical values such that it is essential to an adequate understanding of the role of respect in our moral and political life. (shrink)

BackgroundMild cognitive impairment is a common neurological disorder. Moxibustion has been shown to be effective in treating MCI, but its therapeutic mechanisms still remain unclear. This study mainly aimed to investigate the modulation effect of moxibustion treatment for patients with MCI by functional magnetic resonance imaging.MethodsA total of 47 patients with MCI and 30 healthy controls participated in resting-state fMRI imaging scans. Patients with MCI were randomly divided into true moxibustion group and sham moxibustion group. The degree centrality approach was (...) applied to distinguish altered brain functions. Correlation analysis was then performed to examine the relationships between the neuroimaging findings and clinical symptoms.ResultsCompared with HCs, patients with MCI mainly showed decreased DC in the left middle frontal cortex and bilateral middle cingulate cortex. After moxibustion treatment, the SHAM group had no significant DC findings, while TRUE group mainly showed significant increased DC in the bilateral MFC and MCC, as well as decreased DC in the left middle occipital cortex. Repeated measures analysis of variance showed significant interactions between the two groups of patients with MCI. In addition, the higher Mini-Mental State Examination score was significantly positively correlated with increased DC in the right MFC and left MCC after moxibustion treatment.ConclusionOur findings demonstrate that the potential value of moxibustion treatment on MCI, which adds new insights into the popular view that moxibustion treatment may slow cognitive decline in patients with MCI. (shrink)

This paper distinguishes three major themes in the philosophy of death of the Zhuangzi. It shows that, while these themes are often intertwined in the text, they offer different outlooks on the nature of death and, correspondingly, different arguments about the significance of death and strategies for coping with death. The first sees death as a natural and inevitable part of the process of cosmic transformation that we have to accept or embrace. The second emphasizes the unity, continuity and interdependence (...) of life and death, and advises us to appreciate death from this holistic perspective. The last strand of thought challenges our ability to know about death's nature and value. In addition, the paper reviews a few competing interpretations of the Zhuangzi in recent Anglophone literature and suggests that, first, they can be seen as attempts to articulate and develop different themes in the text, and second, they fail to offer a strong rational ground for the Zhuangist attitudes toward death, in part because they all rely on critical assumptions that are questionable or at least insufficiently defended. (shrink)

This paper critically examines Barclay’s conception of dignity proposed in her ‘Dignitarian Medical Ethics’. According to Barclay, a subject S enjoys dignity if and only if S is reliably treated as having equal social status. I argue that Barclay’s view faces a number of practical and theoretical problems. First, it is not obvious that failing to treat someone as a social equal is incompatible with respecting her dignity. Second, it is not always clear what treating someone as a social equal (...) amounts to in practice. To be more compelling, her conception of dignity needs to be supplemented with a more principled and substantive account of the content of equal treatment. (shrink)

The ancient Chinese text the Zhuangzi raises a mix of epistemological, psychological, and conceptual challenges against the value and usefulness of philosophical disputation. But instead of advocating the elimination of philosophy, it implicitly embraces a broader conception of philosophy, the goal of which is to engage us to reflect on our limitations, question things we take for granted, and better appreciate alternative perspectives and possibilities. Philosophy thus understood is compatible with a variety of methods and approaches: fictions, jokes, paradoxes, spiritual (...) exercises, argument, disputation, and so on. Philosophical practices, on this view, also pave the way for an open‐minded, adaptive and flexible way of living that is at the core of the Zhuangist good life. (shrink)

A human driver and an automated driving system might share control of automated vehicles in the near future. This raises many concerns associated with the assignment of responsibility for negative outcomes caused by them; one is that the human driver might be required to bear the brunt of moral and legal responsibilities. The psychological consequences of responsibility misattribution have not yet been examined. We designed a hypothetical crash similar to Uber’s 2018 fatal crash. We incorporated five legal responsibility attributions. Participants (...) chose their preferred liability attribution and then were randomly assigned into one of the five actual liability attribution conditions. They then responded to a series of questions concerning liability assignment, the crash, and AVs. Slightly more than 50% of participants thought that the human driver should bear full or primary liability. Legal responsibility misattribution negatively influenced these mentioned responses, regardless of overly attributing human or manufacturer liability. Overly attributing human liability had more negative influences. Improper liability attribution might hinder the adoption of AVs. Public opinion should not be ignored in developing a legal framework for AVs. (shrink)

What it is to have a first person perspective? How do we come to understand our own perspective in the world? How do we take into account other people's perspectives in our social and linguistic interactions? This dissertation is an exploration of these issues. But instead of approaching them in the abstract, it aims to shed light on these difficult questions through a series of case studies. First, I examine the role of the first person perspective in our agency, and (...) explain the sense in which it is essential for action. Next, drawing on recent work in psychology, I propose an model of the development of temporal self-understanding in young children. Lastly, I develop a two-level pragmatic theory of epistemic modals. (shrink)

The present study critically evaluates whether school leadership influences student learning homogenously regardless of school contexts. It examined relationships between four principal leadership variables (envisioning, instructional management, promoting professional development, empowerment) and two types of student outcomes (enjoyment in learning science, science achievement,) in different school contexts (in terms of the availability of science resources, quality of science teachers, and school socioeconomic status (SES)). The sample comprised 248,620 students and 9,370 principals in 35 developed countries who participated in the Programme (...) for International Student Assessment (PISA) 2015. Latent profile analysis (LPA) showed that schools operated in three types of school contexts with different levels of science resources, proportion of quality science teachers, and school SES. There were also differences in the pattern of leadership practices across the three types of school contexts. Three-level hierarchical linear modeling (HLM) showed that among the four leadership variables, only instructional management was positively associated with students’ enjoyment of science in schools with less science resources and quality science teachers. Therefore, instructional management had compensatory effects for students in less-endowed schools. In contrast, principal leadership related to envisioning, teacher professional development, and empowerment was not positively related to students’ science learning in all three school contexts. (shrink)

Unlike eggs and diatoms, most single cells in nature do not have structured shells to provide extensive protection. It is a challenge to artificially confer shell structures on living cells to improve their inherent properties and functions. We discuss four different types of cellular shellizations: man‐made hydrogels, sol‐gels, polyelectrolytes, and mineral shells. We also explore potential applications, such as cell storage, protection, delivery, and therapy. We suggest that shellization could provide another means to regulate and functionalize cells. Specifically, the integration (...) of living cells and non‐living functional shells may be developed as a novel strategy to create “super” or intelligent cells. Unlike biological approaches, this material‐based bio‐interface regulation is inexpensive, effective, and convenient, opening up a novel avenue for cell‐based technologies and practices. (shrink)

To identify the common and specific structural basis of bipolar depression and unipolar depression is crucial for clinical diagnosis. In this study, a total of 85 participants, including 22 BD patients, 36 UD patients, and 27 healthy controls, were enrolled. A voxel-based morphology method was used to identify the common and specific changes of the gray matter volume to determine the structural basis. Significant differences in GMV were found among the three groups. Compared with healthy controls, UD patients showed decreased (...) GMV in the orbital part of the left inferior frontal gyrus, whereas BD patients showed decreased GMV in the orbital part of the left middle frontal gyrus. Compared with BD, UD patients have increased GMV in the left supramarginal gyrus and middle temporal gyrus. Our results revealed different structural changes in UD and BD patients suggesting BD and UD have different neurophysiological underpinnings. Our study contributes toward the biological determination of morphometric changes, which could help to discriminate between UD and BD. (shrink)

Chemotherapy is an important therapeutic approach for cancer treatment. However, drug resistance is an obstacle that often impairs the successful use of chemotherapies. Therefore, overcoming drug resistance would lead to better therapeutic outcomes for cancer patients. Recently, studies by our own and other groups have demonstrated that there is an intimate correlation between the loss of the F‐box and WD repeat domain‐containing 7 (FBW7) tumor suppressor and the incurring drug resistance. While loss of FBW7 sensitizes cancer cells to certain drugs, (...) FBW7‐/‐ cells are more resistant to other types of chemotherapies. FBW7 exerts its tumor suppressor function by promoting the degradation of various oncoproteins that regulate many cellular processes, including cell cycle progression, cellular metabolism, differentiation, and apoptosis. Since loss of the FBW7 tumor suppressor is linked to drug resistance, FBW7 may represent a novel therapeutic target to increase drug sensitivity of cancer cells to conventional chemotherapeutics. This paper thus focuses on the new functional aspects of FBW7 in drug resistance. (shrink)

Lifelong premature ejaculation (LPE) is a common male sexual dysfunction. Lack of active control for rapid ejaculation brought great distress to sexual harmony, and even fertility. Previous neurophysiology studies revealed an ejaculation-related control mechanism in the brain. However, it remains unclear whether this inhibitory network is altered in LPE patients. The present study investigated the central inhibitory network function of LPE patients by using stop signal task-related functional magnetic resonance imaging and resting-state functional connectivity analysis. The results showed no difference (...) in task-related behavioral performance or neural activation during response inhibition between LPE patients and controls. However, LPE patients showed a significantly different correlation pattern between the stop signal reaction time (SSRT) and left inferior frontal gyrus activation during successful inhibition, in which a typical negative correlation between SSRT and the activation was completely disappeared in patients. In addition, using the left inferior frontal gyrus as a seed, patients showed weaker functional connectivity between the seed and two areas (left dental nucleus and right frontal pole) compared with controls. These data suggest that LPE patients have an abnormal brain control network, which may contribute to the reduced central control of rapid ejaculation. This study provides new insights into the neural mechanism of LPE involving the central inhibitory network, which may offer an underlying intervention target for future treatment. (shrink)

Closed-loop transcutaneous auricular vagal nerve stimulation was officially proposed in 2020. This work firstly reviewed two existing CL-taVNS forms: motor-activated auricular vagus nerve stimulation and respiratory-gated auricular vagal afferent nerve stimulation, and then proposed three future CL-taVNS systems: electroencephalography -gated CL-taVNS, electrocardiography -gated CL-taVNS, and subcutaneous humoral signals -gated CL-taVNS. We also highlighted the mechanisms, targets, technical issues, and patterns of CL-taVNS. By reviewing, proposing, and highlighting, this work might draw a preliminary blueprint for the development of CL-taVNS.