Several recent lines of inquiry have pointed to the amygdala as a potential lesion site in autism. Because one function of the amygdala may be to produce autonomic arousal at the sight of a significant face, we compared the responses of autistic children to their mothers’ face and to a plain paper cup. Unlike normals, the autistic children as a whole did not show a larger response to the person than to the cup. We also monitored sympathetic activity in autistic (...) children as they engaged in a wide range of everyday behaviours. The children tended to use self-stimulation activities in order to calm hyper-responsive activity of the sympathetic (`fight or flight’) branch of the autonomic nervous system. A small percentage of our autistic subjects had hyporesponsive sympathetic activity, with essentially no electrodermal responses except to self-injurious behaviour. We sketch a hypothesis about autism according to which autistic children use overt behaviour in order to control a malfunctioning autonomic nervous system and suggest that they have learned to avoid using certain processing areas in the temporal lobes. (shrink)

It is imperative that creative techniques be designed for the conduct of active conflict. The failure to explore alternatives to violent force is fostered by an inbred literature which is preoccupied with descriptive analyses of small group conflict or with policy and the implications of nuclear warfare. An entirely new concept is required based upon the union of technique with theory. Psychoanalytic experience with intrapsychic conflict should be brought to bear upon problems of large-scale conflict in a manner not yet (...) attempted. The central questions and their answers may require the fielding of an experimental corps to refine constructive techniques for engaging in conflict. (shrink)

The postwar welfare state provides social insurance against economic, health, and related risks in an uncertain world. Because everyone can envision themselves to be among the unfortunate, social insurance fuses self-interest and solidarism in a normative principle Friedman (2020) calls probabilistic justice. But there is a competing principle of status defense, where the aim is to erect boundaries between socioeconomic strata and discourage cross-class mobility. We argue that this principle dominates when inequality is high and uncertainty low. The current moment (...) is one of high inequality and high uncertainty, which results in intense status anxiety, yet does not rule out solidaristic solutions. Our contributions are to diagnose the causes of our current malaise, and to theorize the normative bases for the political choice facing contemporary western democracies. (shrink)

Perceptual grouping has traditionally been thought to be governed by innate, universal principles. However, recent work has found differences in Japanese and English speakers' non-linguistic perceptual grouping, implicating language in non-linguistic perceptual processes (Iversen, Patel, & Ohgushi, 2008). Two experiments test Japanese- and English-learning infants of 5-6 and 7-8 months of age to explore the development of grouping preferences. At 5-6 months, neither the Japanese nor the English infants revealed any systematic perceptual biases. However, by 7-8 months, the same (...) age as when linguistic phrasal grouping develops, infants developed non-linguistic grouping preferences consistent with their language's structure (and the grouping biases found in adulthood). These results reveal an early difference in non-linguistic perception between infants growing up in different language environments. The possibility that infants' linguistic phrasal grouping is bootstrapped by abstract perceptual principles is discussed. (shrink)

Faced with an increasingly media-saturated, globalized culture, art historians have begun to ask themselves challenging and provocative questions about the nature of their discipline. Why did the history of art come into being? Is it now in danger of slipping into obsolescence? And, if so, should we care? In _Writing Art History_, Margaret Iversen and Stephen Melville address these questions by exploring some assumptions at the discipline’s foundation. Their project is to excavate the lost continuities between philosophical aesthetics, contemporary (...) theory, and art history through close readings of figures as various as Michael Baxandall, Martin Heidegger, Jacques Lacan, and Alois Riegl. Ultimately, the authors propose that we might reframe the questions concerning art history by asking what kind of writing might help the discipline to better imagine its actual practices—and its potential futures. (shrink)

The heme‐containing cytochromes P‐450 are a ubiquitous family of monooxygenase isozymes responsible for the oxidative metabolism of a wide variety of endogenous as well as exogenous compounds. Many of the compounds metabolized by this enzyme system are effectively detoxified and converted to derivatives more easily eliminated from the organism. However, some compounds can be activated to reactive species capable of eliciting a cascade of toxic lesions, including cancer. Since its discovery nearly 30 years ago, the cytochrome P‐450 enzyme system has (...) received a great deal of attention, particularly in the areas of their mechanisms of metabolism, range of substrate specificity, the purification and characterization of the multiple isozymes and, more recently, the regulation of expression of specific forms. This review will discuss current notions concerning the expression of at least one cytochrome P‐450 isozyme and future directions that should lead to a more complete understanding of cytochrome P‐450 gene expression in general, particularly as it impacts upon biochemical pharmacology. (shrink)

It is only now, with the rise of digitalization and the near-obsolescence of traditional technology, that we are becoming fully aware of the distinctive character of analogue photography. This owl-of-Minerva-like appreciation of the analogue has prompted photographic art practices that mine the medium for its specificity. Indeed, one could argue that analogue photography has only recently become a medium in the fullest sense of the term, for it is only when artists refuse to switch over to digital photographic technologies that (...) the question of what constitutes analogue photography as a medium is self-consciously posed. While the benefits of digitalization—in terms of accessibility, dissemination, speed, and efficiency—are universally acknowledged, some people are also beginning to reflect on what is being lost in this great technological revolution. In this context, artists' use of analogue film and the revival of early photographic techniques should be regarded as timely interventions, although these may strike some as anachronistic. This essay does not attempt an ontological inquiry into the essential nature of the analogue; rather, it is an effort to articulate something about the meaning of analogue photography as an artistic medium for contemporary artists by paying close attention to its meaning and stakes for particular artists. Instead of presenting a general survey, I want to consider the work of just two artists, Zoe Leonard and Tacita Dean, both of whose work is concerned with what is being lost. As Leonard put it: “New technology is usually pitched to us as an improvement. … But progress is always an exchange. We gain something, we give something else up. I'm interested in looking at some of what we are losing.”1 Tellingly, both artists have produced exhibitions simply called Analogue. Leonard gave the title to a large project she did between 1998 and 2009 consisting of 412 silver gelatin and c-prints of local shop fronts in lower Manhattan and poor market stalls around the world.2 Dean used it for a 2006 retrospective exhibition of her films, photographs, and drawings. (shrink)

Different areas of child welfare work call for psychometric measurement to replace professionals’ judgements with objective numbers. Using data from a national Swedish evaluation of interventions for abused children, the present article investigates child interviewees’ resistance to constraints in psychometric questions. The article contributes to studies of how psychology operates in institutional settings; it looks into the discursive production of the interviewee’s position in the struggle between the principle of recordability and ‘sensitive’ interviewing. The findings suggest that interviewees resist questions’ (...) structural restrictions in the service of telling the interviewer about their lives. Thus, the function of their misalignment is affiliative; it cooperates both with the institutional goal of eliciting information and with the interviewer’s interest in them. However, the interviewer’s solutions to children’s problem presentations remain focused on generating recordable answers. The article concludes that the narrow focus on recordability neglects important opportunities to talk about children’s experiences. (shrink)

This article examines the relevance of Hegel’s theory of recognition within educational theory and practice in relation to the development of a non-affirmative theory of education. The article argues that Hegel’s theory of recognition can serve as a fruitful starting point for articulating an educational theory that can contribute to the subject’s open-ended formation in modern society. To start with, the article surveys the connection between Hegel’s educational thought and his concept of recognition. Against this backdrop, the article singles out (...) how Hegel’s theory of recognition provides a compelling theory of intersubjectivity that calls attention to the role of norms in personal development and the construction of the social world. In continuation of a non-affirmative principle, it is argued that Hegelian recognition underlines, first, that the subject’s formation can fruitfully be an open-ended and dynamic process and, second, that in order to underpin this process it is necessary to critically assess norms and norm-generating practices within an educational context. (shrink)

i am doing a research for my university about the writing system of ancient egyptian.

En el momento de mayores precisiones sobre la sustancia primera, Metafísica VII es un libro complejo que nuclea numerosos problemas metafísicos y lógicos de la tradición aristotélica. Aparecen allí, por ejemplo, el problema de la unidad de la metafísica, el hilemorfismo, el problema de la ousía primera, el problema del contenido de la definición, etc. En especial, los capítulos 7 a 9 tienen pasajes misteriosos donde se desvía el foco de la discusión que venía dándose en el libro, en tanto (...) abordan los tipos de generación. Asimismo, el análisis hilemórfico de la generación natural que ahí aparece es central para comprender la génesis humana en Aristóteles y la tradición que lo sigue. Ahora bien, en el Comentario a la Metafísica de Tomás de Aquino todo lo antes mencionado toma dimensión y se resignifica a cuento de las discusiones escolásticas. La propuesta de este trabajo tiene dos partes. La primera aspira a leer el análisis de la generación natural en dichos capítulos de la obra aristotélica: con el objetivo de determinar: (i) las notas propias de la doctrina hilemórfica allí presentada; (ii) sus implicancias (a) para con el problema de compatibilizar la noción de ousía de las Categorías y la Metafísica y, (b) para con el problema del contenido de la definición. En segundo término, se analizarán las lectiones 6-8 del Comentario tomista para determinar la reconstrucción que Tomás hace de lo anterior y el impacto que aquello tiene sobre sus doctrinas. (shrink)

The essays collected in this special issue of Critical Inquiry are devoted to reflection on the shifts in photographically based art practice, exhibition, and reception in recent years and to the changes brought about by these shifts in our understanding of photographic art. Although initiated in the 1960s, photography as a mainstream artistic practice has accelerated over the last two decades. No longer confined to specialist galleries, books, journals, and other distribution networks, contemporary art photographers are now regularly the subject (...) of major retrospectives in mainstream fine-art museums on the same terms as any other artist. One could cite, for example, Thomas Struth at the Metropolitan Museum in New York , Thomas Demand at the Museum of Modern Art , or Jeff Wall at Tate Modern and MoMA . Indeed, Wall's most recent museum show, at the time of writing, The Crooked Path at Bozar, Brussels , situated his photography in relation to the work of a range of contemporary photographers, painters, sculptors, performance artists, and filmmakers with whose work Wall considers his own to be in dialogue, irrespective of differences of media. All this goes to show that photographic art is no longer regarded as a subgenre apart. The situation in the United Kingdom is perhaps emblematic of both photography's increasing prominence and its increased centrality in the contemporary art world over recent years. Tate hosted its first ever photography survey, Cruel and Tender, as recently as 2003, and since then photography surveys have become a regular biannual staple of its exhibition programming, culminating in the appointment of Tate's first dedicated curator of photography in 2010. A major shift in the perception of photography as art is clearly well under way. (shrink)

Although there are those who understand that the debates about the morality of the interruption of pregnancy are newly born, when analyzing some passages of the classical sources, the antiquity of such discussions is revealed. Likewise, as the legal, political and moral conclusions in such respects are often based on a metaphysical, anthropological, theological or biological position, it is necessary to enter these fields in order to fully explore the different edges of such a complicated object. In this way, this (...) work aims to show the terminological pitfalls that the words embryon and kyema generate for the understanding of Aristotelian embryology, which is the basis for understanding his position on abortion, as well as the scholastic debates that use this as a source. We aspire to analyze the various appearances of both terms in various works of Aristotle - fundamentally De generatione animalium and De partibus animalium - and show how there is no criterion to distinguish them in most contexts. (shrink)

Autistic individuals without intellectual disabilities are sometimes not diagnosed until adolescence/adulthood. Due to increased risk of co-occurring mental health problems, these individuals may initially be referred to general, mental health services and not always be identified as autistic; some may be misdiagnosed with personality disorder prior to identification of autism. To explore possible mechanisms in misdiagnosis of autism, we report on the case of a young man with severe, non-suicidal self-injury and attention deficit disorder who had been diagnosed with and (...) treated for borderline PD prior to being diagnosed with autism. Following reassessment by mental health clinicians with experience of working with autistic individuals, the patient was diagnosed with autism, ADD, and depression—but not PD. Experiences from this case suggest that presence of co-occurring NSSI, depression, and ADD, as well as lack of comprehensive assessment and lack of autism knowledge in general mental health services, may contribute to risk that autism is misdiagnosed as PD. These findings highlight the need for autism expertise in general mental health services to facilitate appropriate diagnosis for autistic individuals who encounter these services, as well as the importance of undertaking comprehensive assessments. (shrink)

Recent posthuman theories of nature recognition seek to move beyond Hegel’s anthropological starting point. This article serves as a critical rejoinder to such posthuman attempts by taking aim at posthumanism’s flat ontology and concept of agency. Instead, it is suggested that a genuine Hegelian starting point is better suited to discern the complex interrelationship between the human and nonhuman. It is argued that a Hegelian theory of recognition that takes Hegel’s Philosophy of Nature and Philosophy of Mind into consideration can (...) give nature its due while simultaneously preserving humans as the primary locus of agency in answering current environmental problems. (shrink)

This guest column in Common Knowledge presents the concept of “communities of disagreement” to an international and interdisciplinary audience, perhaps for the first time. It takes as its starting point the contrast between agonistic and deliberative democratic theories, and it attempts to outline how democratic groups may live well with unresolved disagreement yet not give on up developing truth-sensitive decision-making processes. It argues against the widespread idea that shared values are the social glue of democratic communities. By developing arguments of (...) Manfred Frank, the article outlines a model of the relationship between social context, interpretation, and information. (shrink)

En el presente trabajo proponemos analizar la lectura procleana del pasaje de _Leyes _X 896a y ss. –donde Platón parece hacer descansar todos los actos de los cuerpos en una causalidad de orden divino y psicológico– como una respuesta a lo antes dicho por Plutarco al respecto. El queroneata sostiene que, según Platón, el mal es causado por un alma mala, que en eterna lucha con el alma buena, oficia de causa mecánica y de principio rector del cosmos (_De Iside (...) et Osiride _370b-371a; _De animae procreatione in Plato Timaeo _1014a-f). A nuestro criterio, es contra lo anterior que se centra el esfuerzo procleano para señalar que el mal no existe en su pureza, ni en las entidades superiores (como lo es el alma del mundo o Alma-hipóstasis) aunque sí como una desviación que se da en las almas humanas individuales y que opera como una entidad parasitaria (_De malorum subsistentia _I, 20-23). Aspiramos a esgrimir argumentos que muestren en qué sentido Proclo defiende el principio Uno-Bien, que no puede tener contrarios, y la existencia del mal en las entidades inferiores sin negar la contingencia ni culpar al cosmos del mal. (shrink)

Ending world hunger remains one of the central global challenges, but the question of how to measure and define the problem is politically charged. This article chronicles and analyses the indicator selection process for SDG 2.1, focusing in particular on the Food Insecurity Experience Scale (FIES) indicator. Despite alleged efforts to separate political and technical aspects in the indicator selection process we find that they were entangled from the start. While there was significant contestation around which indicators should be selected, (...) the process was characterized by pathway lock-in: The complexity of food security quantification and the resource constraints in the process favored already established data infrastructures and milieus of expertise, locking in the position of FAO and its established food security indicators. The SDG 2.1 indicators frame food insecurity in terms of caloric supply and demand and individual experience, arguably excluding dimensions of democratic agency, sustainability and other dimensions and drivers of food insecurity. The lock-in has thus embedded a narrow concept of food security in the major global indicator framework for food security monitoring. This is likely to have significant effects on how food insecurity is addressed nationally and internationally. Addressing the knowledge politics of food security indicators is important to broaden and open the agenda for sustainable transformation of food systems. Statistics and indicators are important tools in this agenda, but a diversity of approaches and data infrastructures from the local to the international level are needed to understand the multiple dimensions and drivers of food insecurity. (shrink)

There are marked differences between countries with regard to reimbursement decision-making, yet few studies have tried to understand this process and its consequences by a detailed analysis of the local context and decision-making structure. This article describes reimbursement decision-making and subsequent prescribing patterns of new pharmaceuticals by means of a case study on glitazones in treatment of type 2 diabetes mellitus patients in Denmark. The study shows that institutional arrangements, providing the context in which evidence is used, are highly important (...) for understanding the reimbursement decision-making process. In particular the Danish Medicines Agency (DMA) has shaped the decision to reimburse glitazones on the basis of physician-mediated requests of individual patients. Relatively few patients have been prescribed glitazones since their introduction in 2000, suggesting that individual reimbursement may be an effective instrument in controlling overall expenditure of selected pharmaceuticals, although in the case of glitazones this has likely been achieved at the expense of equality in access to the products. The discussion focuses on the generalizability of the findings to both other pharmaceuticals in the individual reimbursement scheme in Denmark, and to other countries that are trying to balance the need to control overall pharmaceutical care expenditure with the need to secure equality in access to new drugs with therapeutic added value. (shrink)

Reseña de Gutiérrez, D. Sócrates y la práctica de la espiritualidad.

The way information and communication technology (ICT) develops can promote or hinder the democratic potential of this critical societal infrastructure. Concerns about the role standards development organizations (SDOs) play in this context predate the “digital age” but are reemerging amid substantial changes in the institutional landscape of standardization. This article explores the increasingly critical link between the institutional design of SDOs and the democratic design of ICT. We review some principles of democracy in terms of the design of technology, apply (...) these to standardization, and discuss the role public policy may play here, while distinguishing between input and output legitimacy. (shrink)

The way information and communication technology (ICT) develops can promote or hinder the democratic potential of this critical societal infrastructure. Concerns about the role standards development organizations (SDOs) play in this context predate the “digital age” but are reemerging amid substantial changes in the institutional landscape of standardization. This article explores the increasingly critical link between the institutional design of SDOs and the democratic design of ICT. We review some principles of democracy in terms of the design of technology, apply (...) these to standardization, and discuss the role public policy may play here, while distinguishing between input and output legitimacy. (shrink)

The aim of the study was to compare the acute effects of traditional resistance training and superset training on training duration, training volume and different perceptive measures. Twenty-nine resistance-trained participants performed a whole-body workout traditionally and as supersets of exercises targeting different muscle groups, in a randomized-crossover design. Each session was separated by 4–7 days, and consisted of eight exercises and three sets to failure. Training duration and number of repetitions lifted were recorded during the sessions. Rate of perceived exertion (...) for effort, rate of perceived exertion for discomfort, session displeasure/pleasure, and exercise enjoyment were measured 15 min after each session. Forty-eight hours after the final session participants reported which session they preferred. The superset session led to significantly higher values for RPE and RPD and tended to be higher for sPDF, i.e., more pleasurable, compared to the traditional session. There was no difference in EES. The traditional session led to significantly increased training volume and lasted 23 min longer than the superset session. Eighteen of the participants preferred the superset session, while 11 preferred the traditional session. In conclusion, performing a whole-body workout as a superset session was more time-efficient, but reduced the training volume and was perceived with greater exertion for effort and discomfort than a traditional workout. (shrink)

Tables 2 and 4 contained an incorrect set of values for the mean lunar latitudes associated with the tabulated eclipse possibilities.