Between December 2020 and March 2021, the US Food and Drug Administration and the European Medicines Agency issued Emergency Use Authorizations and Conditional Marketing Authorizations for the distribution of the first COVID-19 vaccines. Although these vaccines were thoroughly assessed before their approval, regulators required companies to continue ongoing placebo-controlled clinical trials in order to gather further reliable scientific information on their safety and efficacy, as well as to start new studies to evaluate additional candidates. The aim of this paper is (...) to present and discuss the ethical issues raised by the tension between the need to continue these types of clinical trials and the obligations related to the protection of the rights and well-being of research participants. Specifically, we question whether—how, and to what extent—fundamental principles governing research involving human beings can be applied to the current pandemic situation. We argue that continuing ongoing placebo-controlled clinical trials can be considered ethically justifiable only if all participants are adequately informed of any developments that may affect their willingness to remain enrolled, including the current situation of resource scarcity and the prioritization criteria established for vaccination. However, we also argue that currently approved vaccines, which are considered safe and effective enough to be administered to millions of people as part of the vaccination campaign, necessarily represent the “best proven intervention” currently available and, therefore, should be used as comparators in future studies instead of placebo. (shrink)

Research integrity (RI) is defined as adherence to ethical principles, deontological duties, and professional standards necessary for responsible conduct of scientific research. Early training on RI, especially for early-career researchers, could be useful to help develop good standards of conduct and prevent research misconduct (RM).The aim of this study is to assess the effectiveness of a training course on RI, by mapping the attitudes of early-career researchers on this topic through a questionnaire built upon the revised version of the Scientific (...) Misconduct Questionnaire and administered to all participants at the beginning and at the end of the course.Results show that after the course, participants reporting a high understanding of the rules and procedures related to RM significantly increased (pre-course: 38.5%, post-course: 61.5%), together with the percentage of those reporting a lack of awareness on the extent of misconduct (pre-course: 46.2%, post-course: 69.2%), and of those who believe that the lack of research ethics consultation services strongly affects RM (pre-course: 15.4%, post-course: 61.5%). Early-career researchers agree on the importance to share with peers and superiors any ethical concern that may arise in research, and to create a work environment that fosters RI awareness.As a whole, results suggest the effectiveness of the course. Institutions should introduce RI training for early-career researchers, together with research methodology, integrity and ethics consultation services to support them. Senior scientists should promote RI into their research practices, and should stimulate engagement in peer-to-peer dialogue to develop good practices based on RI principles. (shrink)

This article analyses the ethical aspects of multistakeholder recommendation systems (RSs). Following the most common approach in the literature, we assume a consequentialist framework to introduce the main concepts of multistakeholder recommendation. We then consider three research questions: who are the stakeholders in a RS? How are their interests taken into account when formulating a recommendation? And, what is the scientific paradigm underlying RSs? Our main finding is that multistakeholder RSs (MRSs) are designed and theorised, methodologically, according to neoclassical welfare (...) economics. We consider and reply to some methodological objections to MRSs on this basis, concluding that the multistakeholder approach offers the resources to understand the normative social dimension of RSs. (shrink)

The first part of this paper will provide a reconstruction of Francis Bacon’s interpretation of Academic scepticism, Pyrrhonism, and Dogmatism, and its sources throughout his large corpus. It shall also analyze Bacon’s approach against the background of his intellectual milieu, looking particularly at Renaissance readings of scepticism as developed by Guillaume Salluste du Bartas, Pierre de la Primaudaye, Fulke Greville, and John Davies. It shall show that although Bacon made more references to Academic than to Pyrrhonian Scepticism, like most of (...) his contemporaries, he often misrepresented and mixed the doctrinal components of both currents. The second part of the paper shall offer a complete chronological survey of Bacon’s assessment of scepticism throughout his writings. Following the lead of previous studies by other scholars, I shall support the view that, while he approved of the state of doubt and the suspension of judgment as a provisional necessary stage in the pursuit of knowledge, he rejected the notion of acatalepsia. To this received reading, I shall add the suggestion that Bacon’s criticism of acatalepsia ultimately depends on his view of the historical conditions that surround human nature. I deal with this last point in the third part of the paper, where I shall argue that Bacon’s evaluation of scepticism relied on his adoption of a Protestant and Augustinian view of human nature that informed his overall interpretation of the history of humanity and nature, including the sceptical schools. (shrink)

This article addresses the power of human technologies to wreak destruction on a planetary scale, such as genetic manipulation and weapons of mass destruction. It proposes the need for a new ethic that would be planetary in scale. Its central aim would be to include the great historical and contemporary diversity of human cognitive and epistemological experience. An "ethic of complexity" can weave together the threads of our common heritage. Although humanity's evolutionary past has been shown to be quite diverse, (...) recent genetic and anthropological research has shown it also to be surprisingly unified. New images and metaphors are providing humanity with a vision that transcends familiar ethnic hatreds and so-called clashes of civilizations. The new planetary culture can be a shining example of unity-in-diversity, or unitas multiplex. It will be robustly diverse, intermixed to the core, and filled with awe at the rich lineages of our common past. (shrink)

This article looks at the prevalent view of time in the history of Western philosophy and science and then contrasts it with the emerging new vision of time as ontologically constructive. Throughout Western history, philosophers and scientists attempted to marginalize and anesthetize the role of time by prioritizing being over becoming. But beginning with the Darwinian revolution in biology, the West could no longer deny the constructive role of time in bringing forth new ontological orders. While the 20th century witnessed (...) the split between the reversible time of physics and the developmental time of biology, the time has now come for this divide to be reconciled. Twenty-first century science is already revealing the constructive role of time in cosmology with the likelihood of multiple universes. In conclusion, the authors speculate that our moment in human cultural development is ripe for a complex, multidimensional, and transdisciplinary understanding of time. (shrink)

Maimonides famously holds that, while it is perfectly possible to know (and say) that God exists, it is impossible to know (and say) what God is like because any positive attri- bution contradicts God’s essential oneness. Consequently, pure equivocity obtains between descriptions of the divine and descriptions of any other being. But this raises a puzzle: Knowledge of God seems vacuous if we lack all comprehension of God’s nature - so how can we have any comprehension of the divine without (...) being able to say what it is that we know? In this essay, I defend the substantiality of the concept of knowledge of God on Maimonides’ apophatic picture. Drawing on the concept of non-propositional knowledge, I argue that knowledge and comprehension can come apart, which lends support to Maimonides’ thesis that knowledge of God, though substantial and objective, cannot be expressed. (shrink)

euroscience of Rule-Guided Behavior brings together, for the first time, the experiments and theories that have created the new science of rules. Rules are central to human behavior, but until now the field of neuroscience lacked a synthetic approach to understanding them. How are rules learned, retrieved from memory, maintained in consciousness and implemented? How are they used to solve problems and select among actions and activities? How are the various levels of rules represented in the brain, ranging from simple (...) conditional ones if a traffic light turns red, then stop to rules and strategies of such sophistication that they defy description? And how do brain regions interact to produce rule-guided behavior? These are among the most fundamental questions facing neuroscience, but until recently there was relatively little progress in answering them. It was difficult to probe brain mechanisms in humans, and expert opinion held that animals lacked the capacity for such high-level behavior. However, rapid progress in neuroimaging technology has allowed investigators to explore brain mechanisms in humans, while increasingly sophisticated behavioral methods have revealed that animals can and do use high-level rules to control their behavior. The resulting explosion of information has led to a new science of rules, but it has also produced a plethora of overlapping ideas and terminology and a field sorely in need of synthesis. In this book, Silvia Bunge and Jonathan Wallis bring together the worlds leading cognitive and systems neuroscientists to explain the most recent research on rule-guided behavior. Their work covers a wide range of disciplines and methods, including neuropsychology, functional magnetic resonance imaging, neurophysiology, electroencephalography, neuropharmacology, near-infrared spectroscopy, and transcranial magnetic stimulation. This unprecedented synthesis is a must-read for anyone interested in how complex behavior is controlled and organized by the brain. (shrink)

Pluralist mathematical realism, the view that there exists more than one mathematical universe, has become an influential position in the philosophy of mathematics. I argue that, if mathematical pluralism is true (and we have good reason to believe that it is), then mathematical realism cannot (easily) be justified by arguments from the indispensability of mathematics to science. This is because any justificatory chain of inferences from mathematical applications in science to the total body of mathematical theorems can cover at most (...) one mathematical universe. Indispensability arguments may thus lose their central role in the debate about mathematical ontology. (shrink)

Tra le avventure del pensiero che la nostra epoca può consegnare con orgoglio alla storia della scienza, una delle più intense e affascinanti è senz’altro l’evento della genesi e dello sviluppo dell’approccio scientifico ai tradizionali problemi della conoscenza. Si è trattato innanzitutto del difficile superamento di un confine disciplinare antico, quel limite che Descartes ha tracciato agli albori della tradizione scientifica moderna e che nel tempo si è trasformato in un vuoto concettuale...

I argue that recent attempts to deflect Access Problems for realism about a priori domains such as mathematics, logic, morality, and modality using arguments from evolution result in two kinds of explanatory overkill: the Access Problem is eliminated for contentious domains, and realist belief becomes viciously immune to arguments from dispensability, and to non-rebutting counter-arguments more generally.

This article presents the first, systematic analysis of the ethical challenges posed by recommender systems through a literature review. The article identifies six areas of concern, and maps them onto a proposed taxonomy of different kinds of ethical impact. The analysis uncovers a gap in the literature: currently user-centred approaches do not consider the interests of a variety of other stakeholders—as opposed to just the receivers of a recommendation—in assessing the ethical impacts of a recommender system.

The existence of fundamental moral disagreements is a central problem for moral realism and has often been contrasted with an alleged absence of disagreement in mathematics. However, mathematicians do in fact disagree on fundamental questions, for example on which set-theoretic axioms are true, and some philosophers have argued that this increases the plausibility of moral vis-à-vis mathematical realism. I argue that the analogy between mathematical and moral disagreement is not as straightforward as those arguments present it. In particular, I argue (...) that pluralist accounts of mathematics render fundamental mathematical disagreements compatible with mathematical realism in a way in which moral disagreements and moral realism are not. 11. (shrink)

Public engagement is one of the fundamental pillars of the European programme for research and innovation _Horizon 2020_. The programme encourages engagement that not only fosters science education and dissemination, but also promotes two-way dialogues between scientists and the public at various stages of research. Establishing such dialogues between different groups of societal actors is seen as crucial in order to attain epistemic as well as social desiderata at the intersection between science and society. However, whether these dialogues can actually (...) help attaining these desiderata is far from obvious. This paper discusses some of the costs, risks, and benefits of dialogical public engagement practices, and proposes a strategy to analyse these argumentative practices based on a three-tiered model of epistemic exchange. As a case study, we discuss the phenomenon of vaccine hesitancy, arguably a result of suboptimal public engagement, and show how the proposed model can shed new light on the problem. (shrink)

Can art, religion, or philosophy afford ineffable insights? If so, what are they? The idea of ineffability has puzzled philosophers from Laozi to Wittgenstein. In Ineffability and its Metaphysics: The Unspeakable in Art, Religion and Philosophy, Silvia Jonas examines different ways of thinking about what ineffable insights might involve metaphysically, and shows which of these are in fact incoherent. Jonas discusses the concepts of ineffable properties and objects, ineffable propositions, ineffable content, and ineffable knowledge, examining the metaphysical pitfalls involved (...) in these concepts. Ultimately, she defends the idea that ineffable insights as found in aesthetic, religious, and philosophical contexts are best understood in terms of self-acquaintance, a particular kind of non-propositional knowledge. Ineffability as a philosophical topic is as old as the history of philosophy itself, but contributions to the exploration of ineffability have been sparse. The theory developed by Jonas makes the concept tangible and usable in many different philosophical contexts. (shrink)

Il presente articolo si propone di spiegare il contesto storico-artistico e il significato politico di due esposizioni dell’immediato dopoguerra svolte a Palazzo Venezia, il quartier generale di Mussolini. Esse sono la Mostra dei capolavori della pittura europea (XV-XVII secoli), che ha luogo dall’agosto 1944 al febbraio 1945, e la Mostra d’arte italiana a Palazzo Venezia, inaugurata a maggio e conclusa nell’ottobre 1945. La prima è organizzata e promossa dal Governo Militare Alleato, la seconda dall’Associazione Nazionale per il Restauro dei Monumenti (...) Danneggiati dalla Guerra, fondata e diretta dal filantropo Umberto Zanotti Bianco. Numerose vicende si intrecciano nell’organizzazione di queste esposizioni, tra cui il lavoro dei Monuments Men, le operazioni di salvataggio del patrimonio mobile da parte di alcuni ex funzionari del Ministero dell’Educazione Nazionale, la nascita del Governo Militare Alleato e delle nuove istituzioni italiane antifasciste, la necessità di restaurare il patrimonio artistico distrutto e la fondazione dell’associazione di Zanotti Bianco. Chiunque voglia affrontare lo studio della situazione storico-artistica del dopoguerra romano e nazionale deve necessariamente fare i conti con le due mostre di Palazzo Venezia. (shrink)

It is well-established that algorithms can be instruments of injustice. It is less frequently discussed, however, how current modes of AI deployment often make the very discovery of injustice difficult, if not impossible. In this article, we focus on the effects of algorithmic profiling on epistemic agency. We show how algorithmic profiling can give rise to epistemic injustice through the depletion of epistemic resources that are needed to interpret and evaluate certain experiences. By doing so, we not only demonstrate how (...) the philosophical conceptual framework of epistemic injustice can help pinpoint potential, systematic harms from algorithmic profiling, but we also identify a novel source of hermeneutical injustice that to date has received little attention in the relevant literature: epistemic fragmentation. Epistemic fragmentation is a structural characteristic of algorithmically-mediated environments that isolate individuals, making it more difficult to develop, uptake and apply new epistemic resources. This, in turn, can impede the identification and conceptualisation of emerging harms in these environments. We trace the occurrence of hermeneutical injustice back to the fragmentation of the epistemic experiences of individuals, who are left more vulnerable by the inability to share, compare, and learn from shared experiences. (shrink)

The recent boom of direct-to-consumer (DTC) genetic tests, aimed at measuring children’s athletic potential, is the latest wave in the ‘pre-professionalization’ of children that has characterized, especially but not exclusively, the USA in the last 15 years or so. In this paper, I analyse the use of DTC genetic tests, sometimes coupled with more traditional methods of ‘talent scouting’, to assess a child’s predisposition to athletic performance. I first discuss the scientific evidence at the basis of these tests, and the (...) parental decision in terms of education, and of investing in the children’s future, taken on the basis of the results of the tests. I then discuss how these parental practices impact on the children’s right to an open future, and on their developing sense of autonomy. I also consider the meaning and role of sports in childhood, and conclude that the use of DTC genetic tests to measure children’s athletic potential should be seen as a ‘wake up’ call for other problematic parental attitudes aimed at scouting and developing children’s talent. (shrink)

What are the relevant values to the appraisal of research programs? This question remains hotly debated, as philosophers have recently proposed many lists of values potentially relevant to scientific appraisal. Surprisingly, despite being mentioned in many lists, little attention has been paid to fruitfulness. It is unclear how fruitfulness should be explicated, and whether it has any substantial role in scientific appraisal. In this paper, I argue we should explicate fruitfulness as the capacity to develop of research programs. Moreover, I (...) provide a novel strategy to assess and compare the fruitfulness of programs focused on their research questions and heuristics. To illustrate how this strategy would work, I will discuss a case study, namely the adaptationist program in evolutionary psychology. (shrink)

The Feeling Brain — The Thinking Soul Recent advances in neuroscience have dramatically improved our understanding of human emotional states. With the help of new technologies and models, scholars are beginning to unravel the "mystery" of emotional life. Confusions in contemporary emotion studies are due to the traditional model of a person as a rational conscious agent. The paper highlights two problematic aspects of this prevailing model: the relation between emotion and reason and the relation between emotion and consciousness. Firstly, (...) it is claimed that the difference between emotions and thoughts does not transcend their mutual interconnectivity. Secondly, conscious content and emotional responses are both products of specialized emotion systems that operate unconsciously. Both claims are supported by experimental findings and clinical practice. (shrink)

Based on the Nietzschean conception of language as rhetoric, the aim is to show how the notion of constitutive artifice denies the naturalness of language and, at the same time, it is linked to the affirmation of an unconscious dimension operating in its functioning.

Modulating connectivity measures in EEG-based neurofeedback studies is assumed to be a promising therapeutic and training tool. However, little is known so far about its effects and trainability. In the present study, we investigated the effects of up- and down-regulating SMR coherence by means of neurofeedback training on EEG activity and memory functions. Twenty adults performed 10 neurofeedback training sessions in which half of them tried to increase EEG coherence between Cz and CPz in the SMR frequency range, while the (...) other half tried to down-regulate coherence. Up-regulation of SMR coherence led to between- and within-session changes in EEG coherence. SMR power increased across neurofeedback training sessions but not within training sessions. Cross-over training effects on baseline EEG measures were also observed in this group. Up-regulation of SMR coherence was also associated with improvements in memory functions when comparing pre- and post-test results. Participants were not able to down-regulate SMR coherence. This group did not show any changes in baseline EEG measures or memory functions comparing pre- and post-test. Our results provide insights in the trainability and effects of connectivity-based neurofeedback training and indications for its practical application. (shrink)

The distinction between propositional and doxastic justification is well-known among epistemologists. Propositional justification is often conceived as fundamental and characterized in an entirely apsychological way. In this chapter, I focus on beliefs based on deductive arguments. I argue that such an apsychological notion of propositional justification can hardly be reconciled with the idea that justification is a central component of knowledge. In order to propose an alternative notion, I start with the analysis of doxastic justification. I then offer a notion (...) of propositional justification, intersubjective propositional justification, that is neither entirely apsychological nor idiosyncratic. To do so, I argue that to be able to attribute propositional justification to a subject, we have to consider her social context as well as broad features of our human cognitive architecture. (shrink)

The aim of this paper is to examine how much Hume knew about astronomy, in order to understand the reasons for his acceptance of Copernicanism. My contention is that Hume’s positive reception of the Copernican system arises at least from the importance that he gives to three features that he attributes to the Copernican system: beauty, simplicity and uniformity. I also give some evidence that Hume had first-hand knowledge of some sections of Galileo’s Dialogo sopra i due massimi sistemi del (...) mondo tolemaico e copernicano (1632), where the “sole proofs” of the Copernican system are said to be found. (shrink)

In two studies, children's concepts of various types of ordinarily unobservable entities were examined. Study 1 confirmed earlier findings in showing that children aged 4–9 years are confident of the existence of scientific entities such as germs as well as religious beings such as God. At the same time, both age groups are skeptical of the existence of various mythical beings such as mermaids. In Study 2, older children aged 10–12 years were probed for their concepts of religious as compared (...) to scientific phenomena. Despite considerable confidence in each type, older children differentiated between them, both with respect to their level of confidence and their pattern of justification. (shrink)

A Steiner triple system (STS) is a set S together with a collection B of subsets of S of size 3 such that any two elements of S belong to exactly one element of B. It is well known that the class of finite STS has a Fraïssé limit M_F. Here, we show that the theory T of M_F is the model completion of the theory of STSs. We also prove that T is not small and it has quantifier elimination, (...) TP2, NSOP1, elimination of hyperimaginaries and weak elimination of imaginaries. (shrink)

Prized Attic honey is an often-neglected topic in studies of Athenian productions, despite the considerable spread of production, as attested by archaeological finds of terracotta beehives throughout the territory. Literary sources also frequently mention honey produced in Attica, especially the most famous and prized variety from Mount Hymettus. In this paper, after a mention of the peculiarity of the traditions about honey in the classical world, the importance and fame of the Attic product is emphasised. The sources that praise the (...) product are here classified in three groups, namely the authors who focus on its sweetness and fragrance, the ones who describe Attic honey generically in relation to its prestige and the sources which compares it to honey from other regions. Afterwards, my further goal is to assess the possible connection between honey and the funerary sphere in Attica. This relation is explored also through the reanalysis of some interpretations proposed for a fictile group of geometric Attic models. (shrink)