BackgroundResponsive neurostimulation has been utilized as a treatment for intractable epilepsy. The RNS System delivers stimulation in response to detected abnormal activity, via leads covering the seizure foci, in response to detections of predefined epileptiform activity with the goal of decreasing seizure frequency and severity. While thalamic leads are often implanted in combination with cortical strip leads, implantation and stimulation with bilateral thalamic leads alone is less common, and the ability to detect electrographic seizures using RNS System thalamic leads is (...) uncertain.ObjectiveThe present study retrospectively evaluated fourteen patients with RNS System depth leads implanted in the thalamus, with or without concomitant implantation of cortical strip leads, to determine the ability to detect electrographic seizures in the thalamus. Detailed patient presentations and lead trajectories were reviewed alongside electroencephalographic analyses.ResultsAnterior nucleus thalamic leads, whether bilateral or unilateral and combined with a cortical strip lead, successfully detected and terminated epileptiform activity, as demonstrated by Cases 2 and 3. Similarly, bilateral centromedian thalamic leads or a combination of one centromedian thalamic alongside a cortical strip lead also demonstrated the ability to detect electrographic seizures as seen in Cases 6 and 9. Bilateral pulvinar leads likewise produced reliable seizure detection in Patient 14. Detections of electrographic seizures in thalamic nuclei did not appear to be affected by whether the patient was pediatric or adult at the time of RNS System implantation. Sole thalamic leads paralleled the combination of thalamic and cortical strip leads in terms of preventing the propagation of electrographic seizures.ConclusionThalamic nuclei present a promising target for detection and stimulation via the RNS System for seizures with multifocal or generalized onsets. These areas provide a modifiable, reversible therapeutic option for patients who are not candidates for surgical resection or ablation. (shrink)

Este artigo retoma os conceitos de poder disciplinar e biopoder em Michel Foucault para, então, fazer um diagnóstico do contexto pandêmico causado pela Covid-19. Ao se considerar que mais da metade da população mundial foi orientada ao isolamento social, bem como à alteração de hábitos cotidianos a fim de diminuir a propagação do vírus SARS-CoV-2, é possível perceber em Foucault as medidas da técnica disciplinar e da tecnologia biopolítica, ambas direcionadas à preservação da vida da população. Considera-se que o poder (...) disciplinar e o biopoder funcionam na atual pandemia num contexto inédito, marcado pelo avanço tecnológico. (shrink)

Two sextants constructed for Tycho Brahe are preserved in the National Technical Museum in Prague. One was constructed by Erasmus Habermel, the other by Jost Bürgi. Both were made in the year 1600. To overcome the observational errors, several improvements were made in the construction of these instruments, especially in the case of Bürgi's sextant. It would appear both from these instruments and from his tables of sines that Tycho wanted to reduce the errors to one minute of arc. A (...) replica of Bürgi's sextant, which is currently under construction, will allow the accuracy of the instrument to be tested. (shrink)

Experiential imagination consists in an imaginative projection that aims at simulating the experiences one would undergo in different circumstances. It has been traditionally thought to play a role in how we build our lives, engage with other agents, and appreciate art. Although some philosophers have recently expressed doubts over the capacity of experiential imagination to offer insight into the perspective of someone other than our present-selves, experiential imagination remains a much sought-after tool. This paper substantiates pessimism about the epistemological value (...) of these uses of experiential imagination by developing an embodied approach. Our thesis is that experiential imagination is _robustly embodied_ because the _sociohistorically situated_ body makes an irreducible contribution to the imaginative project, and that, as such, it is constrained by who we are as _concrete_ agents. We argue that experiential imagination is an embodied, virtual exploration of imagined scenarios that depends on our situated history of sensorimotor and affective interactions. We conclude that experiential imagination is much more limited than commonly acknowledged, as it can hardly be divorced from who we are and where we have been. (shrink)

Hannah Arendt plačiai žinoma kaip filosofė, kuri mėgino reabilituoti senovės graikų politikos sampratą. Remiantis Žmogaus būklės skaitymu, Arendt paprastai laikoma „graikofile“, jai prikišama „Atėnų nostalgija“. Sunku paneigti Arendt simpatijas graikams – ji iš tiesų atsigręžė į atėniečių politikos supratimą, bandydama jame iškristalizuoti kertinius autentiškos politikos elementus. Vis dėlto ši interpretacija yra pernelyg vienpusiška. Didžiausius nuopelnus politikos suvokimo srityje Arendt priskiria ne graikams, o romėnams. Pastarieji žymiai geriau sprendė politikos stabilumo, tęstinumo ir tvarumo problemą. Visą dėmesį sutelkiant į veiksmą, spontaniškumą ir (...) nepaprastus žygdarbius, kyla grėsmė destabilizuoti ir „išcentruoti“ politinės bend­rijos gyvenimą. Romėnai, įvesdami tokias sąvokas kaip tradicija, autoritetas, steigties (įkūrimo) šventumas, teisė (lex), taip pat pabrėždami politinę atleidimo ir pažado reikšmę, atveria graikams svetimą politinės sedimentacijos plotmę. Ši plotmė suteikia būtinus saugiklius, be kurių tvari politinė egzistencija yra neįmanoma. (shrink)

Advocates of interactionism in the ethical criticism of art argue that ethical value impacts aesthetic value. The debate is concerned with “the intrinsic question”: the question of whether ethical flaws/merits in artworks’ manifested attitudes affect their aesthetic value (Gaut 2007: 9). This paper argues that the assumption that artworks have intrinsic ethical value is problematic at least in regards to a significant subset of works: fictional artworks. I argue that, insofar as their ethical value emerges only from attitudes attributable to (...) actual agents, fictional artworks only have extrinsic ethical value. I show that what is at stake for interactionism is whether ethical judgements concerning artists’ attitudes in a context, rather than manifested attitudes, are ever aesthetically relevant. I conclude that, without buying into extreme actual intentionalism, a still controversial theory of interpretation that ties artworks’ meaning to actual artists, interactionism fails to show that ethical flaws/merits are aesthetic flaws/merits. (shrink)

The paper is aimed at rationalizing relationships between the structure of inorganic compounds in condensed phases and their melting and boiling points. It is documented that the main factor governing both points is their molecular or polymeric nature. In case of polymeric ionic compounds, the higher actual charge bearing by the ions involved, the higher their melting/boiling points. In case of covalent polymers, the value of both points increases with polymer dimensionality and with the number and energy of the respective (...) covalent bonds. In case of molecular compounds, both points depend on the weight and shape of molecules, the presence of hydrogen bonds, and electric quadrupole moment. (shrink)

Background and AimsEnd-of-life discussions can be difficult for seriously ill adolescents and young adults. Researchers aimed to determine whether completing Voicing My CHOiCES —a research-informed advance care planning guide—increased communication with family, friends, or health care providers, and to evaluate the experience of those with whom VMC was shared.MethodsFamily, friends, or HCPs who the AYAs had shared their completed VMC with were administered structured interviews to assess their perception of the ACP discussion, changes in their relationship, conversation quality, and whether (...) the discussion prompted changes in care. Open-ended responses underwent thematic analysis.ResultsOne-month post-completion, 65.1% of AYA had shared VMC completion with a family member, 22.6% with a friend, and 8.9% with an HCP. Among a sample of respondents, family and friends reported a positive change in their relationship with the AYA. Participant descriptions of the experience fell into five themes: positive experience, difficult experience, appreciated a guide to facilitate discussion, provided relief, and created worry/anxiety. Only 1 HCP noted a treatment change. Family, friends, and HCP did not think the AYA would have discussed EoL preferences without completing VMC.ConclusionsVMC has potential to enhance communication about ACP between AYA and their family and friends, though less frequently with HCPs. Participants reported a positive change in their relationship with the AYA after discussing VMC, and described experiencing the conversation as favorable, even when also emotionally difficult. (shrink)

This article examines what constitutes an ethical flaw in artworks and asks which ethical flaws are relevant in determining works. ethical and aesthetic values. I argue that while most of the discussion has simply taken for granted that it is intrinsic ethical flaws that should be taken into account, there are further important differences in the type of intrinsic ethical flaws that artworks display. I identify two different types of ethical defects in artworks, fictional and actual, and argue that this (...) distinction has important consequences for debates surrounding the ethical value of works of fiction. (shrink)

This paper examines Hannah Arendt’s account of the relationship between politics and morality. Many critics have argued that Arendt’s conception of political action lacks any moral foundations, while others have tried to focus on her understanding of thinking as a normative source of her ethics. In contrast to these views, I present an alternative explanation and argue that the sources of Arendt’s political ethics are located neither in the faculty of thinking nor in extrapolitical moral norms or rules, but in (...) the ontological conditions of action, specifically worldliness, natality and plurality. This interpretation allows us to make sense of Arendt’s fragmented, unsystematic accounts of the various virtues and moral dispositions required for authentic politics: courage, responsibility, care, respect, moderation, solidarity and gratitude. In particular, an inquiry into the ontological sources of political ethics provides a solid normative grounding for the two moral dispositions—promise and forgiveness—that form an explicit “moral code” of political action for Arendt. (shrink)

This book seeks to arrive at a better understanding of the relationships between the objective and subjective aspects of time. It discusses the existence of fluent time, a controversial concept in many areas, from philosophy to physics. Fluent time is understood as directional time with a past, a present, and a future. We experience fluent time in our lives and we adopt a temporal perspective in our ways of knowing and acting. Nevertheless, the existence of fluent time has been debated (...) for both philosophical and scientific reasons, thus creating a rift between the subjective and objective aspects of time. Starting from the basic notion of points of view, or perspectives, this book explores the relationships between objective or external time, as it has been conceptualized by science, and subjective or internal time, which is involved in our lived experiences. It establishes a general framework encompassing the nature, structure and mode of existence of points of view, in which the objective and subjective aspects of time can be integrated. The book mainly addresses researchers and postgraduates in philosophy and logic. Additionally, it offers inspiration for physicists and computer scientists involved in the modeling and simulation of complex behaviors for which the representation of internal time should be considered together with the notion of objective, external time. (shrink)

It has been pointed out that Sensorimotor Enactivism, a theory that claims that perception is enacted and brought about by movement, says very little about the neural mechanisms that enable perception. For the proponents of the predictive approach to Sensorimotor Enactivism, this is a challenge that can be met by introducing predictive processing into the picture. However, the compatibility between these theories is not straightforward. Firstly, because they seem to differ in their stand towards representations: while Sensorimotor Enactivism is said (...) to belong to the non-representational wing of cognitive science, predictive processing has a representational profile. And secondly, because they exhibit different explanatory strategies: while Sensorimotor Enactivism prioritizes the interactions of the embodied agent, predictive processing has internalist commitments. The aim of this paper is to address these concerns and show that a predictive approach to Sensorimotor Enactivism is viable. More specifically, I focus on the Free-Energy approach, a theory that falls within the ballpark of predictive processing. In this paper I argue for the following claims. I argue that both Sensorimotor Enactivism and the Free-Energy approach may be understood for some systems in representational terms. The non-representational reading of Sensorimotor Enactivism is not mandatory and neither is the representational reading of the Free-Energy approach. Sensorimotor Enactivism is, in this respect, compatible with both representational and non-representational interpretations of the FEA. So, the position towards representations of these frameworks should not stand in the way of a predictive approach to Sensorimotor Enactivism. I also show that the Free-Energy approach allows for an account that prioritizes the interaction of the embodied agent with the environment. This is the explanatory strategy followed by Sensorimotor Enactivism. To justify this strategy and following other proponents of Sensorimotor Enactivism, I argue that by referring to the interactions of the embodied agent a better account of the phenomena in question is provided. On this basis, I claim that Sensorimotor Enactivism and the Free-Energy approach are compatible in what concerns their explanatory strategy as well. Thus, making the case for the viability of the predictive approach to Sensorimotor Enactivism. (shrink)

Advocates of the ethical criticism of art claim that works' ethical defects or merits have an impact on their aesthetic value. Against ethical critics, autonomists claim that moral criteria should not be part of the considerations when evaluating works of art as art. Autonomism refers to the view that an artwork's aesthetic value is independent from its ethical value. The purpose of this paper is to examine how autonomism has been defended in the contemporary discussion in analytic aesthetics. I present (...) three versions of autonomism: Richard Posner's radical autonomism, James C. Anderson and Jeffrey T. Dean, and James Harold's moderate autonomism, and Francisca Pérez Carreño's robust autonomism. I argue that robust autonomism offers a stronger argument against the ethical critic. However, I point to some difficulties for Pérez Carreño's account and conclude by suggesting how further work in autonomism might go around them. (shrink)

Advocates of interactionism in the ethical criticism of art argue that ethical value impacts aesthetic value. The debate is concerned with “the intrinsic question”: the question of whether ethical flaws/merits in artworks’ manifested attitudes affect their aesthetic value (Gaut 2007: 9). This paper argues that the assumption that artworks have intrinsic ethical value is problematic at least in regards to a significant subset of works: fictional artworks. I argue that, insofar as their ethical value emerges only from attitudes attributable to (...) actual agents, fictional artworks only have extrinsic ethical value. I show that what is at stake for interactionism is whether ethical judgements concerning artists’ attitudes in a context, rather than manifested attitudes, are ever aesthetically relevant. I conclude that, without buying into extreme actual intentionalism, a still controversial theory of interpretation that ties artworks’ meaning to actual artists, interactionism fails to show that ethical flaws/merits are aesthetic flaws/merits. (shrink)

Background: The prevalence of anxiety and depression in young students is associated with biosocial factors and scholastic stress. However, few studies have evaluated emotional-affective symptoms that are related to the immune system and antioxidant parameters in young individuals without diagnoses of affective disorders.Aim: This study aims to assess the relationship between emotional-affective symptoms and glutathione concentrations and CD4 and CD8 lymphocyte counts in college students.Methods: College students completed standardized psychometric instruments, including the Perceived Stress Scale, Hamilton Anxiety Scale, Beck Depression (...) Inventory, Familiar Social and Friends Support Scale, and Rosenberg Scale. Blood samples were biochemically analyzed. Analyses of variance were conducted between four groups according to symptom severity.Results: A considerable prevalence of stress, anxiety, and depression symptoms was observed and negatively correlated with self-esteem and socio-familiar support. Perceived stress was sexually dimorphic. Although biochemical parameters were within reference ranges, glutathione, CD4, and CD8 tended to be lower in participants with anxiety and depression symptoms, which may be of predictive value.Conclusion: The relationship between antioxidant/immune parameters and socio-affective scores is latent in undiagnosed college students who might develop affective disorders. The findings suggest that during the initial development of affective disorders, stress management strategies should be implemented to help college students cope with the academic load and monitor negative changes in their physiological state. (shrink)

We provide a new interpretation of Zeno’s Paradox of Measure that begins by giving a substantive account, drawn from Aristotle’s text, of the fact that points lack magnitude. The main elements of this account are (1) the Axiom of Archimedes which states that there are no infinitesimal magnitudes, and (2) the principle that all assignments of magnitude, or lack thereof, must be grounded in the magnitude of line segments, the primary objects to which the notion of linear magnitude applies. Armed (...) with this account, we are ineluctably driven to introduce a highly constructive notion of (outer) measure based exclusively on the total magnitude of potentially infinite collections of line segments. The Paradox of Measure then consists in the proof that every finite or potentially infinite collection of points lacks magnitude with respect to this notion of measure. We observe that the Paradox of Measure, thus understood, troubled analysts into the 1880’s, despite their knowledge that the linear continuum is uncountable. The Paradox was ultimately resolved by Borel in his thesis of 1893, as a corollary to his celebrated result that every countable open cover of a closed line segment has a finite sub-cover, a result he later called the “First Fundamental Theorem of Measure Theory.” This achievement of Borel has not been sufficiently appreciated. We conclude with a metamathematical analysis of the resolution of the paradox made possible by recent results in reverse mathematics. (shrink)

本书包括:在北京广播学院的讲演;在北京青年政治学院报告;沈昌案答辩词;李之焕案答辩词等内容。.

Software vulnerabilities are the root cause for a multitude of security problems in computer systems. Owing to their efficiency and tight control over low-level system resources, the C and C++ programming languages are extensively used for a myriad of purposes, from implementing operating system kernels to user-space applications. However, insufficient or improper memory management frequently leads to invalid memory accesses, eventually resulting in memory corruption vulnerabilities. These vulnerabilities are used as a foothold for elaborated attacks that bypass existing defense methods. (...) In this paper, we summarise the main memory safety violation types (i.e. memory errors), and analyse how they are exploited by attackers and the main mitigation methods proposed in the research community. We further systematise the most relevant techniques with regards to memory corruption identification in current programs. (shrink)

Se realizó un estudio con el objetivo de ejemplificar los modos de actuación en el trabajo metodológico interdisciplinario que respondan a la formación académica, laboral e investigativa de los estudiantes de la carrera de Medicina de la Facultad de Ciencias Médicas de Camagüey, desde una concepción intra e interdisciplinaria, rectorada por la disciplina Informática Médica. Se elaboraron propuestas de tareas docentes problematizadoras desde una estrategia metodológica a partir de la planificación que cada asignatura del año debe diseñar, las que permitieron (...) la realización de trabajos investigativos por los estudiantes en cada semestre del curso escolar, en las que se combinaron de manera creciente los contenidos y los diversos métodos teóricos y prácticos de las unidades curriculares del plan de estudio de las asignaturas Informática Médica, Metodología de la Investigación, Educación Física, Psicología General y Medicina General Integral como disciplina rectora en la carrera, influyendo en la formación de un profesional más competente. Determining a mode of on-the-job acting interdisciplinary methodologic that the intra answer to Camagüey's academic, labor and investigating formation of the students of the carrier of Medicine of Ciencias Médicas's Faculty, from a conception and interdisciplinary, manager for Information-Technology Medical discipline, he identified the objective of this work. The problem from a strategy elaborated bidding of teaching tasks themselves methodologic as from the planning that he must design each subject of study of the year, the ones that permitted the realization of investigating works for students in each semester of the school year, in the ones that combined of increasing manner the contentses and various theoretic methods themselves and pilots of units curriculares of the curriculum of Information-Technology Medical subjects of study, Methodology of Investigation, Physical Education, Psicología General and Medicine General Integral like ruling discipline in the carrier influencing a more competent professional's formation. (shrink)

Aesthetic evaluations of human bodies have important implications for moral recognition and for individuals’ access to social and material goods. Unfortunately, there is a widespread aesthetic disregard for non-white bodies. Aesthetic evaluations depend on the aesthetic properties we regard objects as having. And it is widely agreed that aesthetic properties are directly accessed in our experience of aesthetic objects. How, then, might we explain aesthetic evaluations that systematically favour features associated with white identity? Critical race philosophers, like Alia Al-Saji, Mariana (...) Ortega, Paul C. Taylor, and George Yancy, argue that this is because the perception of racialized bodies is affected by the social structures in which they are appreciated. The aim of this paper is to propose how social structures can affect aesthetic perception. I argue that mental imagery acquired through the interaction with aesthetic phenomena structures the perception of non-aesthetic properties of bodies, so that aesthetic properties consistent with racist stereotypes are attributed to individuals. (shrink)

We describe the results of an experiment on decision making in an insurance context. The experiment was designed to test for the underlying rationality of insurance consumers, where rationality is understood in usual economic terms. In particular, using expected utility as the preference function, we test for positive marginal utility, risk aversion, and decreasing absolute risk aversion, all of which are normal postulates for any microeconomic decision context under uncertainty or risk. We find that there the discrepancy from rational decision (...) making increases with the sophistication of the rationality criteria, that irrationality concerning fair premium contracts is uncharacteristically high, and that the slope of absolute risk aversion seems to depend on the format of the insurance contract. (shrink)

RESUMENEn la obra del pensador gallego Francisco Sánchez (1551-1623), titulada Que nada se sabe, existen una serie de características que nos obligan a relacionarla directamente con el pensamiento judío. Entre estas cuestiones se hallan: las citas bíblicas recogidas por su autor, siendo la gran mayoría de ellas procedentes del Antiguo Testamento; la falta de la dedicatoria a la virgen María o la relación entre el alma y el cuerpo que recoge Sánchez y que es de claro origen judío.PALABRAS CLAVEESCEPTICISMO, PENSAMIENTO (...) JUDÍO, FRANCISCO SÁNCHEZABSTRACTIn the work of the thinker Francisco Sanchez (1551-1623), entitled That nothing is known, there are some characteristics that force us to directly relate it to the Jewish thought. Some of these questions are: the Biblical quotations gathered by its author, coming the great majority of them from the Old Testament; the lack of the dedication to Virgin Mary or the relation between the soul and the body that Sanchez shares with the Jewish tradition. All these topics point at the importance of this tradition in the work That nothing is known.KEYWORDSSCEPTICISM, JEWISH THOUGHT, FRANCISCO SANCHEZ, RENAISSANCE. (shrink)

ResumenEn el marco intelectual del Renacimiento hubo una serie de pensadores que se mostraron disconformes con el aristotelismo dominante. La variedad de sus posturas así como lo distinto de sus posicionamientos filosóficos ha podido actuar como obstáculo para poder ver las similitudes que, en torno a la crítica aristotélica, presentan. El caso de Juan Luis Vives y de Gianfrancesco Pico puede resultar paradigmático, a estos se suma con fuerza Francisco Sánchez, quien dedicó una parte importante de su obra Quod nihil (...) scitur a criticar a Aristóteles, aunque más aún a sus comentaristas.Palabras claveFilosofía del Renacimiento, Francisco Sánchez, Juan Luis Vives, Gianfrancesco Pico, aristotelismo, historia de la filosofía.AbstractIn the intellectual frame of the Renaissance, there were some thinkers who did not agree with the Aristotelism prevailing at the time. The variety of their philosophical positions and opinions may have been an obstacle for an approach to their similarities regarding the Aristotelian critic. The case of Juan Luis Vives and Gianfrancesco Pico della Mirandola can be paradigmatic. Also Francisco Sánchez, who strongly joined their position, devoted an important part of his play Quod nihil scitur to criticize Aristotle –although he focused on his commentators above all.KeywordsPhilosophy in the Renaissance, Francisco Sanchez, Juan Luis Vives, Gianfrancesco Pico, Aristotelism, History of Philosophy. (shrink)

The first cortically based associative circuits integrated olfactory, motivational, and motor information. Many of the neural dynamics present in these evolutionarily ancient, olfactory-motor circuits, such as the broadband frequency, phase, and amplitude modulations seen during recognition of a rewarded olfactory stimulus, are also found in isocortical circuits. These results suggest that mechanisms permitting olfactory associative processing formed the basis for evolutionarily more recent large-scale couplings involving isocortical areas.

Cognitive mechanisms are based in organisms’biology, and results from biological studies suggest that there is unlikely to be a single mechanism for reorienting or for combining information across modules or domains. Rather, there are likely to be multiple, partly overlapping systems for accomplishing nearly all cognitive and behavioral goals, as is the case for biological mechanisms more generally.