Six essential genes located near the mouse albino locus have been identified as required during specific periods of development. Amongst these six, each is required either during the preimplantation stages of development, at specific times during gastrulation, within 12 hrs after birth or during juvenile development. These genes were identified as a result of extensive genetic complementation analysis using embryos homozygous for the albino deletions. Although, in principal, the associated developmental abnormalities could result from loss of multiple genes, the deletion (...) phenotype in one case is identical to that induced by chemical mutagenesis. These results indicate that the abnormalities observed in deletion homozygotes may result from single gene loss. The deletions have proven useful not only as genetic tools to localize the position of the genes, but also as molecular entry points to the regions containing these genes. The current methodology being used to isolate candidate genes from the albino region is also reviewed here. (shrink)

The Phenomenology of Spirit is both one of Hegel's most widely read books and one of his most obscure. The book is the most detailed commentary on Hegel's work available. It develops an independent philosophical account of the general theory of knowledge, culture, and history presented in the Phenomenology. In a clear and straightforward style, Terry Pinkard reconstructs Hegel's theoretical philosophy and shows its connection to ethical and political theory. He sets the work in a historical context and shows (...) the contemporary relevance of Hegel's thought for European and Anglo-American philosophers. The principal audience for the book is teachers and students of philosophy, but the great interest in Hegel's work and the clarity of Pinkard's exposition ensure that historians of ideas, political scientists, and literary theorists will also read it. (shrink)

The phrase "the meaning of life" for many seems a quaint notion fit for satirical mauling by Monty Python or Douglas Adams. But in this spirited, stimulating, and quirky enquiry, famed critic Terry Eagleton takes a serious if often amusing look at the question and offers his own surprising answer. Eagleton first examines how centuries of thinkers and writers--from Marx and Schopenhauer to Shakespeare, Sartre, and Beckett--have responded to the ultimate question of meaning. He suggests, however, that it is (...) only in modern times that the question has become problematic. But instead of tackling it head-on, many of us cope with the feelings of meaninglessness in our lives by filling them with everything from football to sex, Kabbala, Scientology, "New Age softheadedness," or fundamentalism. On the other hand, Eagleton notes, many educated people believe that life is an evolutionary accident that has no intrinsic meaning. If our lives have meaning, it is something with which we manage to invest them, not something with which they come ready made. Eagleton probes this view of meaning as a kind of private enterprise, and concludes that it fails to holds up. He argues instead that the meaning of life is not a solution to a problem, but a matter of living in a certain way. It is not metaphysical but ethical. It is not something separate from life, but what makes it worth living--that is, a certain quality, depth, abundance and intensity of life. Here then is a brilliant discussion of the problem of meaning by a leading thinker, who writes with a light and often irreverent touch, but with a very serious end in mind. "If you were to ask what provides some meaning in life nowadays for a great many people, especially men, you could do worse than reply 'football.' Not many of them perhaps would be willing to admit as much; but sport stands in for all those noble causes--religious faith, national sovereignty, personal honor, ethnic identity--for which, over the centuries, people have been prepared to go to their deaths. It is sport, not religion, which is now the opium of the people.". (shrink)

Terry F. Godlove discovers in Immanuel Kant's theoretical philosophy resources that have much wider implications beyond Christianity and the philosophical issues that concern monotheism and its beliefs. For Godlove, Kant's insights, when properly applied, can help rejuvenate our understanding of the general study of religion and its challenges. He therefore bypasses what is usually considered to be the "Kantian philosophy of religion" and instead focuses on more fundamental issues, such as Kant's account of concepts, experience, and reason and their (...) significance in controversial matters. _Kant and the Meaning of Religion_ is a subtle and penetrating effort by a leading contemporary philosopher of religion to redefine and reshape the contours of his discipline through a sustained reflection on Kant's so-called "humanizing project.". (shrink)

The sounds that make up spoken words are heard in a series and must be mapped rapidly onto words in memory because their elements, unlike those of visual words, cannot simultaneously exist or persist in time. Although theories agree that the dynamics of spoken word recognition are important, they differ in how they treat the nature of the competitor set—precisely which words are activated as an auditory word form unfolds in real time. This study used eye tracking to measure the (...) impact over time of word frequency and 2 partially overlapping competitor set definitions: onset density and neighborhood density. Time course measures revealed early and continuous effects of frequency (facilitatory) and on set based similarity (inhibitory). Neighborhood density appears to have early facilitatory effects and late inhibitory effects. The late inhibitory effects are due to differences in the temporal distribution of similarity within neighborhoods. The early facilitatory effects are due to subphonemic cues that inform the listener about word length before the entire word is heard. The results support a new conception of lexical competition neighborhoods in which recognition occurs against a background of activated competitors that changes over time based on fine-grained goodness-of-fit and competition dynamics. (shrink)

The phrase "the meaning of life" for many seems a quaint notion fit for satirical mauling by Monty Python or Douglas Adams. But in this spirited Very Short Introduction, famed critic Terry Eagleton takes a serious if often amusing look at the question and offers his own surprising answer. Eagleton first examines how centuries of thinkers and writers--from Marx and Schopenhauer to Shakespeare, Sartre, and Beckett--have responded to the ultimate question of meaning. He suggests, however, that it is only (...) in modern times that the question has become problematic. But instead of tackling it head-on, many of us cope with the feelings of meaninglessness in our lives by filling them with everything from football to sex, Kabbala, Scientology, "New Age softheadedness," or fundamentalism. On the other hand, Eagleton notes, many educated people believe that life is an evolutionary accident that has no intrinsic meaning. If our lives have meaning, it is something with which we manage to invest them, not something with which they come ready made. Eagleton probes this view of meaning as a kind of private enterprise, and concludes that it fails to holds up. He argues instead that the meaning of life is not a solution to a problem, but a matter of living in a certain way. It is not metaphysical but ethical. It is not something separate from life, but what makes it worth living--that is, a certain quality, depth, abundance and intensity of life. Here then is a brilliant discussion of the problem of meaning by a leading thinker, who writes with a light and often irreverent touch, but with a very serious end in mind. (shrink)

This study is divided into three parts: the classical tradition; Althusser and after; and modern debates. It includes chapters on class consciousness, ideology and utopia, and the epistemology of sociology, looking at the work of Georg Lukas, Karl Mannheim and Lucien Goldman respectively.

He sets out not just to expose the illusions of postmodernism but to show the students he has in mind that they never believed what they thought they believed ...

Natural languages vary widely in the degree to which they make use of nested compositional structure in their grammars. It has long been noted by linguists that the languages historically spoken in small communities develop much deeper levels of compositional embedding than those spoken by larger groups. Recently, this observation has been confirmed by a robust statistical analysis of the World Atlas of Language Structures. In order to examine this connection mechanistically, we propose an agent‐based model that accounts for key (...) cultural evolutionary features of language transfer and language change. We identify transitivity as a physical parameter of social networks critical for the evolution of compositional structure and the hierarchical patterning of scale‐free distributions as inhibitory. (shrink)

There are two main ways in which an interest in the sociology of literature can be justified. The first form of justification is realist: literature is in fact deeply conditioned by its social context, and any critical account of it which omits this fact is therefore automatically deficient. The second way is pragmatist: literature is in fact shaped by all kinds of factors and readable in all sorts of contexts, but highlighting its social determinants is useful and desirable from a (...) particular political standpoint.Both of these cases would seem to have something going for them. Hardly anybody would want to deny that literature is in an important sense a social product; but this claim is so general that a specifically “sociological” treatment of literary works does not necessarily follow from it. Metaphors and line endings, after all, are also in some sense social products, so that to attend to these elements of a literary text is not necessarily to deny the work’s sociality. “Social product” would seem too comfortably broad a category, just as “economic product” would seem too crippingly narrow. A problem with the realist case about the sociology of literature, then, is that it is not very clear what exactly is being claimed. The pragmatist case would seem a persuasive rationale for, say, a feminist reading of Alexander Pope’s Essay on Criticism, since few people would want to claim that the poem was in some central way about patriarchal relations in the sense that The Rape of the Lock is. A Marxist critic who attended to questions of social class in Treasure Island, perhaps placing Long John Silver in the context of the British shop stewards’ movement and celebrating his antagonism to the gentry, would not necessarily be committed to holding that these issues were “in fact” crucial to the text; he or she would insist instead that they should be brought to light because they were crucial to history and society in general. Terry Eagleton’s recent works include collected essays—Against the Grain and William Shakespeare—as well as a novel, Saints and Scholars. His work in progress is on the ideology of the aesthetic. (shrink)

The philosophical account of vagueness I call "transvaluationism" makes three fundamental claims. First, vagueness is logically incoherent in a certain way: it essentially involves mutually unsatisfiable requirements that govern vague language, vague thought-content, and putative vague objects and properties. Second, vagueness in language and thought (i.e., semantic vagueness) is a genuine phenomenon despite possessing this form of incoherence—and is viable, legitimate, and indeed indispensable. Third, vagueness as a feature of objects, properties, or relations (i.e., ontological vagueness) is impossible, because of (...) the mutually unsatisfiable conditions that such putative items would have to meet. In this paper I set forth the core claims of transvaluationism in a way that acknowledges and explicitly addresses a challenging critique by Timothy Williamson of my prior attempts to articulate and defend this approach to vagueness. I sketch my favored approach to truth and ontological commitment, and I explain how it accommodates the impossibility of ontological vagueness. I argue that any approach to the logic and semantics of vagueness that both (i) eschews epistemicism and (ii) thoroughly avoids positing any arbitrary sharp boundaries (either first-order or higher-order) will have to be not an alternative to transvaluationism but an implementation of it. I sketch my reasons for repudiating epistemicism. I briefly describe my current thinking about how to accommodate intentional mental properties with vague content within an ontology that eschews ontological vagueness. And I revisit the idea, which played a key role in my earlier articulations of transvaluationism, that moral conflicts provide an illuminating model for understanding vagueness. (shrink)

I explore the prospects for overcoming the prima facie tension in the following four claims, all of which I accept: the phenomenal character of experience is narrow; virtually all aspects of the phenomenal character of experience are intentional; the most fundamental kind of mental intentionality is fully constituted by phenomenal character; and yet introspection does not by itself reliably generate answers to certain philosophically important questions about the phenomenally constituted intentional content of experience. The apparent tension results from the following (...) initially plausible thought: if indeed the answers to such questions are entirely fixed by phenomenal character by itself, then presumably these answers should be directly available introspectively. I focus the discussion specifically on certain questions about the phenomenal intentional content of agentive experience—e.g., the question whether the content of agentive experience is compatible with causal determinism. I consider three alternative possibilities for explaining why the answers to such questions are not directly available introspectively—two of which I argue against and the third of which I embrace. (shrink)

Presenting no less than a history and critique of the concept of the aesthetic throughtout modern Western thought, The Ideology of the Aesthetic is a critical survey of modern Western philosphy, focusing in particular on the complex relations between aesthetics, ethics, and politics.

In the second half of the eighteenth century, German philosophy came for a while to dominate European philosophy. It changed the way in which not only Europeans, but people all over the world, conceived of themselves and thought about nature, religion, human history, politics, and the structure of the human mind. In this rich and wide-ranging book, Terry Pinkard interweaves the story of 'Germany' - changing during this period from a loose collection of principalities into a newly-emerged nation with (...) a distinctive culture - with an examination of the currents and complexities of its developing philosophical thought. He examines the dominant influence of Kant, with his revolutionary emphasis on 'self-determination', and traces this influence through the development of romanticism and idealism to the critiques of post-Kantian thinkers such as Schopenhauer and Kierkegaard. His book will interest a range of readers in the history of philosophy, cultural history and the history of ideas. (shrink)

The ancient sorites paradox has important implications for metaphysics, for logic, and for semantics. Metaphysically, the paradox can be harnessed to produce a powerful argument for the claim that there cannot be vague objects or vague properties. With respect to logic, the paradox forces a choice between the highly counterintuitive ‘epistemic’ account of vagueness and the rejection of classical two-valued logic. Regarding semantics, nonclassical approaches to the logic of vagueness lead naturally to the idea that truth, for vague discourse, is (...) not direct language-world correspondence grounded in referential connections linking a statement’s basic subsentential constituents (names, predicates, the apparatus of quantification) to real objects and real properties; rather, truth is a matter of indirect correspondence between vague language and nonvague reality. (shrink)

In Chapters 4 and 5 of his 1998 book From Metaphysics to Ethics: A Defence of Conceptual Analysis, Frank Jackson propounds and defends a form of moral realism that he calls both ‘moral functionalism’ and ‘analytical descriptivism’. Here we argue that this metaethical position, which we will henceforth call ‘analytical moral functionalism’, is untenable. We do so by applying a generic thought-experimental deconstructive recipe that we have used before against other views that posit moral properties and identify them with certain (...) natural properties, a recipe that we believe is applicable to virtually any metaphysically naturalist version of moral realism. The recipe deploys a scenario we call Moral Twin Earth. (shrink)

One of the founders of modern philosophical thought Georg Wilhelm Friedrich Hegel has gained the reputation of being one of the most abstruse and impenetrable of thinkers. This major biography of Hegel offers not only a complete account of the life, but also a perspicuous overview of the key philosophical concepts in Hegel's work in a style that will be accessible to professionals and non-professionals alike. Terry Pinkard situates Hegel firmly in the historical context of his times. The story (...) of that life is of an ambitious, powerful thinker living in a period of great tumult dominated by the figure of Napoleon. The Hegel who emerges from this account is a complex, fascinating figure of European modernity, who offers us a still compelling examination of that new world born out of the political, industrial, social, and scientific revolutions of his period. (shrink)

The sounds that make up spoken words are heard in a series and must be mapped rapidly onto words in memory because their elements, unlike those of visual words, cannot simultaneously exist or persist in time. Although theories agree that the dynamics of spoken word recognition are important, they differ in how they treat the nature of the competitor set—precisely which words are activated as an auditory word form unfolds in real time. This study used eye tracking to measure the (...) impact over time of word frequency and 2 partially overlapping competitor set definitions: onset density and neighborhood density. Time course measures revealed early and continuous effects of frequency (facilitatory) and on set based similarity (inhibitory). Neighborhood density appears to have early facilitatory effects and late inhibitory effects. The late inhibitory effects are due to differences in the temporal distribution of similarity within neighborhoods. The early facilitatory effects are due to subphonemic cues that inform the listener about word length before the entire word is heard. The results support a new conception of lexical competition neighborhoods in which recognition occurs against a background of activated competitors that changes over time based on fine-grained goodness-of-fit and competition dynamics. (shrink)

This is a fascinating study of the a-temporal nature of evil in the West. The international authors who have contributed to this text not only concentrate on political, social and legally sanctioned cruelty from the past and present, but also explore the nature of moral transgression in contemporary art, media and literature. Although many forms and practices of what might be called evil' are analysed, all are bound by violence and/or the sexually perverse.

The sounds that make up spoken words are heard in a series and must be mapped rapidly onto words in memory because their elements, unlike those of visual words, cannot simultaneously exist or persist in time. Although theories agree that the dynamics of spoken word recognition are important, they differ in how they treat the nature of the competitor set—precisely which words are activated as an auditory word form unfolds in real time. This study used eye tracking to measure the (...) impact over time of word frequency and 2 partially overlapping competitor set definitions: onset density and neighborhood density. Time course measures revealed early and continuous effects of frequency (facilitatory) and on set based similarity (inhibitory). Neighborhood density appears to have early facilitatory effects and late inhibitory effects. The late inhibitory effects are due to differences in the temporal distribution of similarity within neighborhoods. The early facilitatory effects are due to subphonemic cues that inform the listener about word length before the entire word is heard. The results support a new conception of lexical competition neighborhoods in which recognition occurs against a background of activated competitors that changes over time based on fine‐grained goodness‐of‐fit and competition dynamics. (shrink)

It has often been thought that our knowledge of ourselves is _different_ from, perhaps in some sense _better_ than, our knowledge of things other than ourselves. Indeed, there is a thriving research area in epistemology dedicated to seeking an account of self-knowledge that would articulate and explain its difference from, and superiority over, other knowledge. Such an account would thus illuminate the descriptive and normative difference between self-knowledge and other knowledge.¹ At the same time, self- knowledge has also encountered its (...) share of skeptics – philosophers who refuse to accord it any descriptive, let alone normative, distinction. In this paper, we argue that there is at least one _species_ of self-knowledge that is different from, and better than, other knowledge. It is a specific kind of knowledge of one’s concurrent phenomenal experiences. Call knowledge of one’s own phenomenal experiences _phenomenal knowledge_. Our claim is that some (though not all) phenomenal knowledge is different from, and better than, non-phenomenal knowledge. In other. (shrink)

Despite the lack of invariance problem (the many‐to‐many mapping between acoustics and percepts), human listeners experience phonetic constancy and typically perceive what a speaker intends. Most models of human speech recognition (HSR) have side‐stepped this problem, working with abstract, idealized inputs and deferring the challenge of working with real speech. In contrast, carefully engineered deep learning networks allow robust, real‐world automatic speech recognition (ASR). However, the complexities of deep learning architectures and training regimens make it difficult to use them to (...) provide direct insights into mechanisms that may support HSR. In this brief article, we report preliminary results from a two‐layer network that borrows one element from ASR, long short‐term memory nodes, which provide dynamic memory for a range of temporal spans. This allows the model to learn to map real speech from multiple talkers to semantic targets with high accuracy, with human‐like timecourse of lexical access and phonological competition. Internal representations emerge that resemble phonetically organized responses in human superior temporal gyrus, suggesting that the model develops a distributed phonological code despite no explicit training on phonetic or phonemic targets. The ability to work with real speech is a major advance for cognitive models of HSR. (shrink)

The question of when and how bottom‐up input is integrated with top‐down knowledge has been debated extensively within cognition and perception, and particularly within language processing. A long running debate about the architecture of the spoken‐word recognition system has centered on the locus of lexical effects on phonemic processing: does lexical knowledge influence phoneme perception through feedback, or post‐perceptually in a purely feedforward system? Elman and McClelland (1988) reported that lexically restored ambiguous phonemes influenced the perception of the following phoneme, (...) supporting models with feedback from lexical to phonemic representations. Subsequently, several authors have argued that these results can be fully accounted for by diphone transitional probabilities in a feedforward system (Cairns et al., 1995; Pitt & McQueen, 1998). We report results strongly favoring the original lexical feedback explanation: lexical effects were present even when transitional probability biases were opposite to those of lexical biases. (shrink)

What is real? Less than you might think. We advocate austere metaphysical realism---a form of metaphysical realism claiming that a correct ontological theory will repudiate numerous putative entities and properties that are posited in everyday thought and discourse, and also will even repudiate numerous putative objects and properties that are posited by well confirmed scientific theories. We have lately defended a specific version of austere metaphysical realism which asserts that there is really only one concrete particular, viz., the entire cosmos (...) (see Horgan and Potr (2000, 2002), Potr (2003)). But there are various potential versions of the generic position we are here calling austere metaphysical realism; and it is the generic view that constitutes the ontological part of the overall approach to realism and truth that we will describe here. What is true? More than you might think, given our austere metaphysical realism. We maintain that truth is semantically correct affirmability, under contextually operative semantic standards. We also maintain that most of the time, the contextually operative semantic standards work in such a way that semantic correctness (i.e., truth) is a matter of indirect correspondence rather than direct correspondence between thought or language on the one hand, and the world on the other.1 When correspondence is indirect rather than direct, a given statement (or thought) can be true even if the correct ontology does not include items answering to all the referential commitments (as we will here call them) of the statement. 2 This means that even if a putative object is repudiated by a correct ontological theory, ordinary statements that are putatively about that object may still be true. For instance, the statement “The University of St. Andrews is in Scotland” can be semantically correct (i.e., true) even if the right ontology does not include any entity answering to the referring term ‘The University of St. Andrews’, or any entity... (shrink)

Abstract:Statutory approaches toward whistle-blowing currently appear to be based on the assumption that most observers of wrongdoing will report it unless deterred from doing so by fear of retaliation. Yet our review of research from studies of whistle-blowing behavior suggests that this assumption is unwarranted. We propose that an alternative legislative approach would prove more successful in encouraging valid whistle-blowing and describe a model for such legislation that would increase self-monitoring of ethical behavior by organizations, with obvious benefits to society (...) at large.A defense contractor’s inspectors used improper calibration standards when inspecting missile parts and other military products, used noncertified inspectors when inspecting such products, and used employees without top-secret clearance to work on classified projects. This created potentially life-threatening products as well as potential compromises of military secrets.Quality-control officials on the Trans Alaska Pipeline were threatened with physical harm, demoted, and spied on in an effort to force them not to turn in negative reports or report problems. As a result, the likelihood of damaging oil spills due to improperly built and maintained equipment is heightened.A major corporation allegedly initiated an analysis of the cost savings that would result from circumventing or reducing compliance with health, safety and environmental standards. Two officers who objected to this noncompliance cost/benefit analysis were subsequently fired. (shrink)

This article takes as its starting point the observation that neoliberalism is a concept that is ‘oft-invoked but ill-defined’. It provides a taxonomy of uses of the term neoliberalism to include: an all-purpose denunciatory category; ‘the way things are’; an institutional framework characterizing particular forms of national capitalism, most notably the Anglo-American ones; a dominant ideology of global capitalism; a form of governmentality and hegemony; and a variant within the broad framework of liberalism as both theory and policy discourse. It (...) is argued that this sprawling set of definitions are not mutually compatible, and that uses of the term need to be dramatically narrowed from its current association with anything and everything that a particular author may find objectionable. In particular, it is argued that the uses of the term by Michel Foucault in his 1978–9 lectures, found in The Birth of Biopolitics, are not particularly compatible with its more recent status as a variant of dominant ideology or hegemony theories. It instead proposes understanding neoliberalism in terms of historical institutionalism, with Foucault’s account of historical change complementing Max Weber’s work identifying the distinctive economic sociology of national capitalisms. (shrink)

Understanding Computers and Cognition presents an important and controversial new approach to understanding what computers do and how their functioning is related to human language, thought, and action. While it is a book about computers, Understanding Computers and Cognition goes beyond the specific issues of what computers can or can't do. It is a broad-ranging discussion exploring the background of understanding in which the discourse about computers and technology takes place. Understanding Computers and Cognition is written for a wide audience, (...) not just those professionals involved in computer design or artificial intelligence. It represents an important contribution to the ongoing discussion about what it means to be a machine, and what it means to be human. Book jacket. (shrink)

Why do leaders fail ethically? In this book, Terry L. Price applies a multi-disciplinary approach to an understanding of immorality in the public, private, and non-profit sectors. He argues that leaders can know that a certain kind of behavior is generally required by morality but nonetheless be mistaken as to whether the relevant moral requirement applies to them in a particular situation and whether others are protected by this requirement. Price articulates how leaders make exceptions of themselves, explains how (...) the justificatory force of leadership gives rise to such exception-making, and develops normative prescriptions that leaders should adopt as a response to this feature of their moral psychology. (shrink)

In Homelessness, Liberty and Property, Terry Skolnik establishes a novel theory about the government's duties to end homelessness, maintain public property's value, and legitimize laws that regulate public space. In doing so, Skolnik provides new insight into how the property law system and the regulation of public space limit unhoused persons' freedom and political equality. The book deepens our understanding of how various areas of law, such as constitutional law, legal philosophy, criminal law, and property law, approach the reality (...) of homelessness and advances original arguments to provide new justifications for the right to housing. Skolnik concludes by offering a set of concrete proposals for how the government can reduce the incidence of homelessness and treat unhoused persons with greater concern and respect. This title is part of the Flip it Open Programme and may also be available open access. Check our website Cambridge Core for details. (shrink)