Unrealistic optimism is a bias that leads people to believe, with respect to a specific event or hazard, that they are more likely to experience positive outcomes and/or less likely to experience negative outcomes than similar others. The phenomenon has been seen in a range of health-related contexts—including when prospective participants are presented with the risks and benefits of participating in a clinical trial. In order to test for the prevalence of unrealistic optimism among participants of early-phase oncology trials, we (...) conducted a survey with patients over 18 years of age who were enrolled in a phase I, phase I/II, or phase II clinical cancer trial in the New York City area between August 2008 and October 2009. Participants in our study were asked to compare their own chances of experiencing a range of risks and benefits related to the trial they were enrolled in with the chances of the other trial participants. We found a significant optimistic bias in their responses. Respondents tended to overestimate the benefits of the trial they were enrolled in and underestimate its risks. In addition, we found no significant relationship between respondents’ understanding of the trial’s purpose and how susceptible they were to unrealistic optimism. Our findings suggest that improving the consent process for oncology studies requires more than addressing deficits in understanding. (shrink)

Purpose This paper aims to examine exceptionalisms in ethics in general and in the fields of animal and technology ethics in particular. Design/methodology/approach This paper reviews five sample works in animal/technology ethics it considers representative for particularly popular forms of “exceptionalism”. Findings The shared feature of the exceptionalisms exhibited by the chosen samples appears to be born out of the cultural and biological history, which provides powerful intuitions regarding the on “specialness”. Research limitations/implications As this paper is mostly a critique (...) of existing approaches, it contains only a limited amount of counter-proposed alternative approaches. Practical implications This is a discussion worth having because arguments based on exceptionalism have more chance of resulting in significantly altered theoretical conclusions and practical suggestions for normative guidance than non-exceptionalist perspectives. Social implications The approaches critiqued in this paper have a significant effect on the way the authors approach animals, machines/technologies and each other. Originality/value The paper identifies intuitive notions of exceptionalism and argues in favour of a reformist, ethical expansionist stance, which views humanity as residing on the same plane of ethical significance as any other entity regardless of its material composition. (shrink)

Purpose Recent research has found unrealistic optimism among patient-subjects in early-phase oncology trials. Our aim was to investigate the cognitive and motivational factors that evoke this bias in this context. We expected perceptions of control to be a strong correlate of unrealistic optimism. Methods A study of patient-subjects enrolled in early-phase oncology trials was conducted at two sites in the USA. Respondents completed questionnaires designed to assess unrealistic optimism and several risk attribute variables that have been found to evoke the (...) bias in other contexts. Results One hundred and seventy-one patient-subjects agreed to be interviewed for our study. Significant levels of perceived controllability were found with respect to all nine research-related questions. Perceptions of control were found to predict unrealistic optimism. Two other risk attribute variables, awareness of indicators and mental image, were correlated with unrealistic optimism. However, in multivariate regression analysis, awareness and mental image dropped out of the model and perceived controllability was the only factor independently associated with unrealistic optimism. Conclusion Patient-subjects reported that they can, at least partially, control the benefits they receive from participating in an early-phase oncology trial. This sense of control may underlie unrealistic optimism about benefiting personally from trial participation. Effective interventions to counteract unrealistic optimism may need to address the psychological factors that give rise to distorted risk/benefit processing. (shrink)

Examines the role of language in Nietzsche's thought, including the relationship between style and subjectivity, the semiological underpinnings of his theory of tragedy, his naturalism, and his theory of language and rhetoric.

This dissertation examines the questions of interpretation raised by the naturalist vocabulary employed by Nietzsche in the writings of his last creative years, 1885-88. In particular, the concepts of life, physiology and nature which are central to these texts are elucidated in relation to the theory of language and rhetoric that Nietzsche developed in the early 1870's. The first chapter details the problems posed by this naturalistic vocabulary: in particular whether it justifies the interpretation of Nietzsche as a contradictory and (...) irrational thinker, who criticizes metaphysics only to reinscribe a naturalistic metaphysics within his own philosophy. The chapter concludes with the hypothesis that it is appropriate to approach the later writings in light of Nietzsche's early theory of language and rhetoric. The second chapter is devoted to a close reading of the two most important texts by Nietzsche on the subject of language and rhetoric, the essay "On Truth and Lie in the Extra-Moral Sense" and the notes for the course on rhetoric. The third chapter examines the relationship between these texts and The Birth of Tragedy, written eighteen months earlier. Here I argue that the model of signification articulated in "On Truth and Lie" and the course on rhetoric is already operative in the earlier text. Drawing on the conclusions of the two preceding chapters, the final chapter returns to address the question of Nietzsche's naturalism. The concepts of life, physiology and nature are elucidated in relation to Nietzsche's theory of language and rhetoric and the various textual models at work in these texts. (shrink)

_This first book-length work of the prominent German philosopher Gunter Figal to appear in English offers a radical defense of metaphysical philosophy in the era of postmodern thought._.

Egoismus wie Genuß scheinen heutzutage zunächst ichbezogen und daher asozial; Erfahren und Erkennen, Genießen und Produzieren stehen sich merkwürdig fern. Eher selten geht - wie für den jungen Karl Marx - der "Anblick eines bunten Luftspringers" entschieden über den eines "ängstlich-zugeknöpften, in sich geduckten Indivi-duums". Genuß und Egoismus können jedoch als verbunden gedacht und so als unverzichtbar erfahren werden für menschlich verfaßte Gemeinschaften. Geschichtlich haben beson-ders die Literatur sowie Teile der Sozial- und Moralphilosophie zu einem solchen Denken Beiträge geleistet. Eine (...) Reihe dieser Konzepte - von Augustinus bis zu neuen Modernetheorien in Lateinamerika, mit dem Schwerpunkt im 18. und 19. Jahrhundert - genauer zu begreifen und zu vergegenwärtigen ist das Ziel des Buches. Sie zeigen: Das Vergnügen, aus eignen Mitteln eine ganze Welt zu bauen, vermag zu den höchsten zu zählen. Welten verlieren an Lebenswert, wenn sie dieses Vergnügen aufs Geistige beschränken oder die Selbstsucht gar hinter Masken und in die entfremdete Existenz zwingen. Der Anspruch, für sich genießend zu produzieren, kommt - allen Dementis der Praxis zum Trotz - aus gesundem Menschenverstand und ist ein Menschenrecht. Die Autoren des Buches sind Romanisten und Komparatisten, Philosophiehistoriker, Anglisten und Amerikanisten, sie haben ihre Texte aus Anlaß des 75. Geburtstages des Aufklärungsforschers, Stendhal-Kenners, Literaturtheoretikers und genießenden Egotisten Manfred Naumann, über den einige Beiträge und eine umfassende Bibliographie der Schriften informieren, zur Verfügung gestellt. (shrink)

The title of Babette Babich’s recent book might surprise many readers. While many would agree that Nietzsche undertakes a critique of science or Wissenschaft, and of the concepts of objectivity and truth which it presupposes, there appears to be little evidence in Nietzsche’s work of the type of sustained, critical reflection which would merit being called a philosophy of science. The central aim of Babich’s book is to reverse this impression. With an impressive knowledge of Nietzsche’s oeuvre and a keen (...) eye for the nuances of his texts, Babich persuasively argues that the problem of science is central to Nietzsche’s work, by showing how, for Nietzsche, science and art are inextricably linked. (shrink)