Predictive processing is often presented as a unifying framework for perception, action, and cognition, being able to explain most mental phenomena : with regard to perception, the brain harbours a generative model issuing top-down expectations that are matched against bottom-up sensory feedback. Mismatches lead to error messages and model updates until the brain is 'getting it right'. The core notion of prediction error minimization commits the framework to a specification of accuracy conditions. We therefore turn to issues related to the (...) determination of satisfaction conditions discussed in the philosophy of perception. In particular, we rely on work by Recanati who shows that the accuracy conditions of perceptual content are partly determined by the intentional mode and the perceiver. It is important to notice that the self can enter the specification of accuracy conditions in two ways, namely as subject or as object. Even if we do not perceive ourselves explicitly as an object, we always implicitly represent ourselves as subject. We discuss whether and how these two ways of self-representation can be respected in the predictive processing framework. (shrink)

In a competitive, globalised world, corporate social responsibility (CSR) is proposed as a strategy to invigorate the competitiveness of small- and medium-sized enterprises (SMEs). The primary objective of this paper is to identify CSR factors that influence the competitiveness of SMEs and to develop a hypothesised model that can be tested on SMEs. Although SMEs in Uganda are increasingly becoming the backbone of the economy, their rate of survival and competitiveness are a cause for concern. The outcomes of CSR activities (...) can help to improve the survival rate of SMEs, and may offer great opportunities for business competitiveness, locally and globally. (shrink)

This article provides ethical guidance on using race in health research as a variable or in defining the study population. To this end, a plain, non-exhaustive checklist is provided for researchers and research ethics committees, preceded by a brief introduction on the need for justification when using race as a variable or in defining a study population, the problem of exoticism, that distinctions pertain between race, ethnicity and ancestry, the problematic naming of races, and that race does not serve well (...) as a presumed biological construct in genetic research. (shrink)

How should we think about synthetic biology—about the potential benefits and risks of these applications as well as the very idea of designed, extensively genetically modi­fied organisms? The lead article in this report sets out our thinking, but the article is rounded out with nine commentaries that sometimes expand on and sometimes argue with our perspective. Jonathan Wolff, a philosopher at the University College of London and a member of the Nuffield Council on Bioethics, and Mark Bedau, a philosopher at (...) Reed College and a participant in several projects aimed at de­veloping artificial cells, discuss the potential consequences of synthetic biology and suggest some reasons for a precau­tionary approach to deliberating about the consequences. Jane Calvert, reader in science, technology, and innovation studies at the University of Edinburgh and a member of the Nuffield Council on Bioethics working party on emerging biotechnologies, recommends, however, that deliberation about the governance of emerging technologies focus less on consequences than on aims and purposes.Gigi Gronvall, senior associate at the Center for Health Security in the University of Pittsburgh Medical Center, and David Relman, a microbiologist and immunologist at the Stanford School of Medicine, offer contrasting per­spectives about a question we raise concerning “the eth­ics of knowledge”—the values at stake in generating and disseminating potentially dangerous information. Gaymon Bennett offers some ruminations on the questions we raise about how synthetic biology might change the human re­lationship to nature in morally significant ways. He argues, too, that we can think about the ethics of synthetic biology more effectively by getting “upstream” in another way—by sitting next to the bioengineers doing the work and study­ing their “everyday practice” rather than by paying attention only to what is thought and said about their work. Colleen Grogan, professor at the University of Chicago's School of Social Administration and an expert on democratic partici­patory processes in governance, builds on our comments about the challenge of creating a meaningful public dialog about synthetic biology. Jim Thomas, a researcher with the ETC Group, challenges our view of how the public debate about synthetic biology is trending. And Sarah Carter, a policy analyst with the J. Craig Venter Institute, puts our discussion about synthetic biology in the context of debates about other new products and technologies. (shrink)

Voix et écriture -- Esprit libre -- Intuition éthique -- Crise persistante et/ou développement durable -- Éventer le réel.

Every year, hundreds of patients in England die whilst waiting for a kidney transplant, and this is evidence that the current system of altruistic-based donation is not sufficient to address the shortage of kidneys available for transplant. To address this problem, we propose a monopsony system whereby kidney donors can opt-in to receive financial compensation, whilst still preserving the right of individuals to donate without receiving any compensation. A monopsony system describes a market structure where there is only one ‘buyer’—in (...) this case the National Health Service. By doing so, several hundred lives could be saved each year in England, wait times for a kidney transplant could be significantly reduced, and it would lessen the burden on dialysis services. Furthermore, compensation would help alleviate the common disincentives to living kidney donation, such as its potential associated health and psychological costs, and it would also help to increase awareness of living kidney donation. The proposed system would also result in significant cost savings that could then be redirected towards preventing kidney disease and reducing health disparities. While concerns about exploitation, coercion, and the ‘crowding out’ of altruistic donors exist, we believe that careful implementation can mitigate these issues. Therefore, we recommend piloting financial compensation for living kidney donors at a transplant centre in England. (shrink)

In this paper, I argue for an embodied, embedded approach to predictive processing and thus align the framework with situated cognition. The recent popularity of theories conceiving of the brain as a predictive organ has given rise to two broad camps in the literature that I call free energy enactivism and cognitivist predictive processing. The two approaches vary in scope and methodology. The scope of cognitivist predictive processing is narrow and restricts cognition to brain processes and structures; it does not (...) consider the body-beyond-brain and the environment as constituents of cognitive processes. Free energy enactivism, on the other hand, includes all self-organizing systems that minimize free energy and thus does not offer any unique explanations for more complex cognitive phenomena that are unique to human cognition. Furthermore, because of its strong commitment to the mind-life continuity thesis, it does not provide an explanation of what distinguishes more sophisticated cognitive systems from simple systems. The account that I develop in this paper rejects both of these radical extremes. Instead, I propose a compromise that highlights the necessary components of predictive processing by making use of a mechanistic methodology of explanation. The starting point of the argument in this paper is that despite the interchangeable use of the terms, prediction error minimization and the free energy principle are not identical. But this distinction does not need to disrupt the status quo of the literature if we consider an alternative approach: Embodied, Embedded Predictive Processing. EEPP accommodates the free energy principle, as argued for by free energy enactivism, but it also allows for mental representations in its explanation of cognition. Furthermore, EEPP explains how prediction error minimization is realized but, unlike cognitivist PP, it allocates a constitutive role to the body in cognition. Despite highlighting concerns regarding cognitivist PP, I do not wish to discredit the role of the neural domain or representations as free energy enactivism does. Neural structures and processes undeniably contribute to the minimization of prediction error but the role of the body is equally important. On my account, prediction error minimization and free energy minimization are deeply dependent on the body of an agent, such that the body-beyond-brain plays a constitutive role in cognitive processing. I suggest that the body plays three constitutive roles in prediction error minimization: The body regulates cognitive activity, ensuring that cognition and action are intricately linked. The body acts as distributor in the sense that it carries some of the cognitive load by fulfilling the function of minimizing prediction error. Finally, the body serves to constrain the information that is processed by an agent. In fulfilling these three roles, the agent and environment enter into a bidirectional relation through influencing and modeling the structure of the other. This connects EEPP to the free energy principle because the whole embodied agent minimizes free energy in virtue of being a model of its econiche. This grants the body a constitutive role as part of the collection of mechanisms that minimize prediction error and free energy. The body can only fulfill its role when embedded in an environment, of which it is a model. In this sense, EEPP offers the most promising alternative to cognitivist predictive processing and free energy enactivism. (shrink)

The notion of ubuntu and communalism is of great importance in anAfrican educational discourse, as well as inAfrican Philosophy of Education and in Africanphilosophical discourse. Ubuntu is aphilosophy that promotes the common good ofsociety and includes humanness as an essentialelement of human growth.

The last few years have seen dramatic progress in the development of HIV pre-exposure prophylaxis (PrEP). These developments have been met by ethical concerns. HIV interventions are often thought to be ethically difficult. In a context which includes disagreements over human rights, controversies over testing policies, and questions about sexual morality and individual responsibility, PrEP has been seen as an ethically complex intervention. We argue that this is mistaken, and that in fact, PrEP does not raise new ethical concerns. Some (...) of the questions posed by PrEP are not specific to HIV prophylaxis, but simply standard public health considerations about resource allocation and striking a balance between individual benefit and public good. We consider sexual disinhibition in the context of private prescriptions, and conclude that only unjustified AIDS-exceptionalism or inappropriate moralism about sex supports thinking that PrEP raises new ethical problems. This negative conclusion is significant in a context where supposed ethical concerns about PrEP have been raised, and in the context of HIV exceptionalism. (shrink)

In this article, a brief survey of some of the ways in which biblical scholars try to make sense of the coronavirus disease 2019 (COVID-19) pandemic is offered. The views of the following scholars are discussed: Walter Brueggemann, Ying Zhang, John Goldingay and Kathleen Scott Goldingay, N.T. Wright, Philemon M. Chamburuka and Ishanesu S. Gusha, and Peter Lampe. This is followed by the reflections of a biblical scholar and a systematic theologian. From the perspective of a biblical scholar, the following (...) issues are raised: the richness of biblical traditions, the influence of social location on the interpretation of the pandemic in the light of the Bible, the importance of the emphasis on lament, the reluctance to interpret the pandemic as a punishment from God, the importance of the interpreter’s view of God and the emphasis on the way in which the ‘new normal’ should be approached. From the perspective of a systematic theologian the following issues are discussed: The nature of doing theology, the role of the symbol of the Divine, performativity of sense-making, the Trinitarian confession, an emerging new self and the importance of an ethic of responsibility. Contribution: The article is a response to the COVID-19 pandemic and emphasises the critical importance of engaging the Christian scripture. The role accorded to hermeneutics and to an explicit interdisciplinary conversation makes a particular contribution to the emerging crisis discourse. (shrink)

SMEs are the driving force of economies. However, they face challenges that affect their long-term survival, such as developing ethical business environments. Business ethicsrelated research is underdeveloped in SMEs, thus limiting our understanding of business ethics in SMEs. The purpose of this qualitative study was to investigate how business ethics is conceptualised in SMEs, using the Delphi Technique. In SMEs, business ethics is viewed as doing the right thing, having integrity, being transparent, trustworthy, and behaving responsibly towards internal and external (...) parties. The contribution of this article is that business ethics is perceived as upholding quality, being transparent and trustworthy. (shrink)

We have synthesized a 582,970-base pair Mycoplasma genitalium genome. This synthetic genome, named M. genitalium JCVI-1.0, contains all the genes of wild-type M. genitalium G37 except MG408, which was disrupted by an antibiotic marker to block pathogenicity and to allow for selection. To identify the genome as synthetic, we inserted "watermarks" at intergenic sites known to tolerate transposon insertions. Overlapping "cassettes" of 5 to 7 kilobases (kb), assembled from chemically synthesized oligonucleotides, were joined by in vitro recombination to produce intermediate (...) assemblies of approximately 24 kb, 72 kb ("1/8 genome"), and 144 kb ("1/4 genome"), which were all cloned as bacterial artificial chromosomes in Escherichia coli. Most of these intermediate clones were sequenced, and clones of all four 1/4 genomes with the correct sequence were identified. The complete synthetic genome was assembled by transformation-associated recombination cloning in the yeast Saccharomyces cerevisiae, then isolated and sequenced. A clone with the correct sequence was identified. The methods described here will be generally useful for constructing large DNA molecules from chemically synthesized pieces and also from combinations of natural and synthetic DNA segments. 10.1126/science.1151721. (shrink)

The aim of this study is to explore how nurses perceive patient participations of patients over 75 years old undergoing hemodialysis treatment in dialysis units, and of their next of kin. Ten nurses told stories about what happened in the dialysis units. These stories were analyzed with critical discourse analysis. Three discursive practices are found: (1) the nurses’ power and control; (2) sharing power with the patient; and (3) transferring power to the next of kin. The first and the predominant (...) discursive practice can be explained with an ideology of paternalism, in which the nurses used biomedical explanations and the ethical principle of benefice to justify their actions. The second can be explained with an ideology of participation, in which the nurses used ethical narratives as a way to let the patients participate in the treatment. The third seemed to involve autonomous decision-making and the ethical principle of autonomy for the next of kin in the difficult end-of-life decisions. (shrink)

We have identified a sample of 53 societies outside of the classical Himalayan and Marquesean area that permit polyandrous unions. Our goal is to broadly describe the demographic, social, marital, and economic characteristics of these societies and to evaluate some hypotheses of the causes of polyandry. We demonstrate that although polyandry is rare it is not as rare as commonly believed, is found worldwide, and is most common in egalitarian societies. We also argue that polyandry likely existed during early human (...) history and should be examined from an evolutionary perspective. Our analysis reveals that it may be a predictable response to a high operational sex ratio favoring males and may also be a response to high rates of male mortality and, possibly, male absenteeism. Other factors may contribute, but our within-polyandry sample limits analysis. (shrink)

Big Ideas for Little Kids includes everything a teacher, a parent, or a college student needs to teach philosophy to elementary school children from picture books. Written in a clear and accessible style, the book explains why it is important to allow young children access to philosophy during primary-school education. Wartenberg also gives advice on how to construct a "learner-centered" classroom, in which children discuss philosophical issues with one another as they respond to open-ended questions by saying whether they agree (...) or disagree with what others have said. (shrink)

Mani lived in a world where many ideas contributed to his unique theology. In the scriptural legacy of Mani seven of his books show influence of Ethiopian Enoch. These books are identified in this article and the use of Enochic material in those books is discussed. The Manichaean myth is briefly discussed and used to propose that Enochic influence can mainly be found in the way First Enoch depicted characters and presented the cosmos. Mani adopted his ideas mainly from the (...) Book of the Watchers , the Book of Parables and the Astronomical Book of Enoch where evil beings and cursed places are depicted. (shrink)

In this incisive and thought-provoking book, Francois Venter illuminates the issues arising from the fact that the current language of constitutional law is strongly premised on a particular worldview rooted in the history of the states around the North Atlantic Ocean. Highlighting how this terminological hegemony is being challenged from various directions, Venter explores the problem that all constitutional comparatists face: that they all must use the same words to express different meanings. Offering a compact but comprehensive constitutional (...) history, Venter investigates the ways in which the standard vocabulary does not fit comfortably in many contemporary constitutional orders, as well as examining how its cogency is increasingly being questioned. Chapters contextualize comparative constitutional methods to demonstrate how the language choices made by comparatists are shaped by their own perspectives, arguing that careful explanation of the meanings attached to constitutional terms is imperative in order to be persuasive or even understood. Tackling the foundational elements of the field, this book will be a critical read for constitutional scholars across the globe. It will also be of interest to high-level practitioners of constitutional law and political scientists for its investigation of terminology that is crucial to their work. (shrink)

Arguing that psychologists and their predecessors have invariably relied on metaphors in articulation, the contributors to this volume offer a new "key" to understanding a critically important area of human knowledge by specifying the major metaphors.

In February 2022, the Court of Protection was faced with the question of whether a kidney transplant was in the best interests of William Verden. The case highlighted the legal, ethical and clinical complexities of treating potential kidney transplant patients with impaired decision-making. Above all, it exposed the potential risk of discrimination on the basis of disability when treatment decisions in relation to potential kidney recipients with impaired capacity are being made. In this paper, we draw on the Verden case (...) to (1) examine the role of the Court of Protection in cases relating to patients with impaired decision-making capacity who require a transplant, (2) to highlight the lack of empirical data on patients who have faced inequitable access to transplant and (3) highlight the shortcomings of the existing legal and regulatory framework in England and Wales guiding clinical decision making for patients in William’s position. We consequently argue that there is a clear need for action to ensure equitable access to transplant for those in William’s position. Furthermore, we suggest that there is a responsibility incumbent on policy makers and clinicians alike to develop a meaningful, and meaningfully operational, framework centred on preventing discrimination against potential organ recipients based on their decision-making capacity. (shrink)

This article uses cognitive linguistics and an embodied cognitive approach to analyse the passage of Proverbs 1:20-33. The poem, presented as a prophetic threat, uses metaphoric language to depict the dialogue between personified wisdom and metaphorised human beings. The analysis indicates that there is a coherence of metaphors in the target domain shared by both metaphorised source domains of wisdom and the hearers. Using bodily metaphors it stresses the need of wisdom to be internalised by men.

Spirituality and ultimacy are inextricably linked. Underlying the plurality of spiritualities are myriad ways to construe the identity of the transcendent. In a Christian sense, the notion of the divine with a Trinitarian identification is central. The article examines the implications of such a naming of God for spirituality. Attention is paid to the relationship between doctrinal theology and spirituality as well as to scholarly reflection already undertaken on a so-called Trinitarian spirituality. The article suggests guidelines for future work and (...) emphasises that an adequate account should be given of how Trinitarian theology is undertaken as symbolising and hermeneutical endeavour. Some unique features of this spirituality are profiled, and it is argued that a Trinitarian imagining of the divine may generate perspectives not possible in an unqualified monotheistic approach. (shrink)