Rare copy number variants have a prominent role in the aetiology of schizophrenia and other neuropsychiatric disorders. Substantial risk for schizophrenia is conferred by large CNVs at several loci, including microdeletions at 1q21.1, 3q29, 15q13.3 and 22q11.2 and microduplication at 16p11.2. However, these CNVs collectively account for a small fraction of cases, and the relevant genes and neurobiological mechanisms are not well understood. Here we performed a large two-stage genome-wide scan of rare CNVs and report the significant association of copy (...) number gains at chromosome 7q36.3 with schizophrenia. Microduplications with variable breakpoints occurred within a 362-kilobase region and were detected in 29 of 8,290 patients versus 2 of 7,431 controls in the combined sample. All duplications overlapped or were located within 89 kilobases upstream of the vasoactive intestinal peptide receptor gene VIPR2. VIPR2 transcription and cyclic-AMP signalling were significantly increased in cultured lymphocytes from patients with microduplications of 7q36.3. These findings implicate altered vasoactive intestinal peptide signalling in the pathogenesis of schizophrenia and indicate the VPAC2 receptor as a potential target for the development of new antipsychotic drugs. © 2011 Macmillan Publishers Limited. All rights reserved. (shrink)

This chapter presents an overview of the major interpretations of probability followed by an outline of the objective Bayesian interpretation and a discussion of the key challenges it faces. I discuss the ramifications of interpretations of probability and objective Bayesianism for the philosophy of mathematics in general.

This paper examines the early years of the eighteenth-century scientific periodical Observations sur la physique, sur l'histoire naturelle et sur les arts , or ‘Rozier's Journal’, after François Rozier . Rozier's Journal is seen as a transitional and competing genre for scientific publication directed at shortcomings in the learned society press and in contemporary scientific communications. The evolution of this role is traced as the Journal emerged from the independent press between 1771 and 1773. It is argued that Rozier's Journal, (...) limited to the sciences physiques , marked only a step towards the specialized periodical of the nineteenth century. The professional character of Rozier's intended audience is suggested, and Rozier's unexpectedly close ties to the scientific societies are explored. The Journal is seen to be part of both the old and the new, a unique case in the ancien régime press. (shrink)

In this volume a diverse group of economists, philosophers, political scientists, and psychologists address the problems, principles, and practices involved in comparing the well-being of different individuals. A series of questions lie at the heart of this investigation: What is the relevant concept of well-being for the purposes of comparison? How could the comparisons be carried out for policy purposes? How are such comparisons made now? How do the difficulties involved in these comparisons affect the status of utilitarian theories? This (...) collection constitutes the most advanced and comprehensive treatment of one of the cardinal issues in social theory. (shrink)

Two different versions of the ending of the first additament to C. S. Peirce's 1908 article, "A Neglected Argument for the Reality of God," appear in the Collected Papers but were omitted from The Essential Peirce. In one, he linked the hypothesis of God's Reality to his entire theory of logic as semeiotic, claiming that proving the latter would also prove the former. In the other, he offered a final outline of his cosmology, in which the Reality of God as (...) Ens necessarium is indispensable to both the origin and order of our existing universe of Signs. Exploring these passages, as well as the unpublished manuscript drafts of the article, provides important insights into the key concepts of instinct and continuity within Peirce's comprehensive system of thought. (shrink)

Drawing on philosophy, political and social theory, decision-theory, economics, psychology, history and literature, Jon Elster's classic book Sour Grapes continues and complements the arguments of his acclaimed earlier book, Ulysses and the Sirens. Elster begins with an analysis of the notation of rationality, before tackling the notions of irrational behavior, desires and belief with highly sophisticated arguments that subvert the orthodox theories of rational choice. Presented in a fresh series livery and with a specially commissioned preface written by Richard Holton, (...) illuminating its continuing importance to philosophical enquiry, Sour Grapes has been revived for a new generation of readers. (shrink)

The Problem of Iterated Ground is to explain what grounds truths about ground: if Γ grounds φ, what grounds that Γ grounds φ? This paper develops a novel solution to this problem. The basic idea is to connect ground to explanatory arguments. By developing a rigorous account of explanatory arguments we can equip operators for factive and non-factive ground with natural introduction and elimination rules. A satisfactory account of iterated ground falls directly out of the resulting logic: non- factive grounding (...) claims, if true, are zero-grounded in the sense of Fine. (shrink)

In this paper, I link philosophical discussion of policies for trans inclusion or exclusion, to a method of policy making. I address the relationship between concerns about safety, fairness, and inclusion in policy making about the inclusion of transwomen athletes into women’s sport. I argue for an approach based on lexical priority rather than simple ‘balancing’, considering the different values in a specific order. I present justifying reasons for this approach and this lexical order, based on the special obligations of (...) International Federations such as World Rugby. As a result, I provide a justificatory framework for the WR Guidelines that exclude transwomen from the women’s game in WR competitions. Finally, I give an account of a maximally safe, maximally fair and maximally inclusive form of sex categorisation in sport. (shrink)

Sour Grapes aims to subvert orthodox theories of rational choice through the study of forms of irrationality. Dr Elster begins with an analysis of the notation of rationality, to provide the background and terms for the subsequent discussions, which cover irrational behaviour, irrational desires and irrational belief. These essays continue and complement the arguments of Jon Elster's earlier book, Ulysses and the Sirens. That was published to wide acclaim, and Dr Elster shows the same versatility here in drawing on philosophy, (...) political and social theory, decision-theory, economics and psychology, as well as history and literature. (shrink)

I discuss three recent counterexamples to the transitivity of grounding due to Jonathan Schaffer. I argue that the counterexamples don’t work and draw some conclusions about the relationship between grounding and explanation.

This book is an expanded and revised edition of the author's critically acclaimed volume Nuts and Bolts for the Social Sciences. In twenty-six succinct chapters, Jon Elster provides an account of the nature of explanation in the social sciences. He offers an overview of key explanatory mechanisms in the social sciences, relying on hundreds of examples and drawing on a large variety of sources - psychology, behavioral economics, biology, political science, historical writings, philosophy and fiction. Written in accessible and jargon-free (...) language, Elster aims at accuracy and clarity while eschewing formal models. In a provocative conclusion, Elster defends the centrality of qualitative social sciences in a two-front war against soft and hard forms of obscurantism. (shrink)

This 1989 book is intended as an introductory survey of the philosophy of the social sciences. It is essentially a work of exposition which offers a toolbox of mechanisms - nuts and bolts, cogs and wheels - that can be used to explain complex social phenomena. Within a brief compass, Jon Elster covers a vast range of topics. His point of departure is the conflict we all face between our desires and our opportunities. How can rational choice theory help us (...) understand our motivation and behaviour? More significantly, what happens when the theory breaks down but we still cleave to a belief in the power of the rational? Elster describes the fascinating range of forms of irrationality - wishful thinking, the phenomenon of sour grapes, discounting the future in noncooperative behaviour. This is a remarkably lucid and comprehensive introduction to the social sciences for students of political science, philosophy, sociology and economics. (shrink)

In this paper I discuss a new conception that has arrived relatively recently on the scene, in the context of the debate over the inclusion of transwomen (hereafter TW) in female sport. That conception is ‘Meaningful Competition’ (hereafter MC) – a term used by some of those who advocate for the inclusion of TW in female sport if and only if they reduce their testosterone levels. I will argue that MC is not fair. I understand MC as a substitute concept, (...) as an attempt to substitute for the perfectly serviceable concept of fair competition. It is an attempt at conceptual engineering that should be resisted. This is important because some International Federations have accepted MC as good coin, and the underlying theory of MC, which I explicate for the first time, underpins the stance taken by the IOC (International Olympic Committee) in its Framework Document. To establish that the inclusion of TW in female sport meets the criteria of MC in the sense I explicate here, does not show that the inclusion of TW in female sport is fair. Such inclusion is not fair, and the proper currency of sport is fair competition. ‘Meaningful Competition’, on the other hand, is a snare and a delusion. (shrink)

Jon Elster has written a comprehensive, wide-ranging book on the emotions in which he considers the full range of theoretical approaches. Drawing on history, literature, philosophy and psychology, Elster presents a complete account of the role of the emotions in human behaviour. While acknowledging the importance of neurophysiology and laboratory experiment for the study of emotions, Elster argues that the serious student of the emotions can learn more from the great thinkers and writers of the past, from Aristotle to Jane (...) Austen. He attaches particular importance to the work of the French moralists, notably La Rochefoucauld, who demonstrated the way esteem and self-esteem shape human motivation. The book also maintains a running dialogue with economists and rational-choice theorists. Combining methodological and theoretical arguments with empirical case-studies and written with Elster's customary verve and economy, this book has great cross-disciplinary appeal. (shrink)

This book was first published in 1984, as the revised edition of a 1979 original. The text is composed of studies in a descending sequence from perfect rationality, through imperfect and problematical rationality, to irrationality. Specifically human rationality is characterized by its capacity to relate strategically to the future, in contrast to the myopic 'gradient climbing' of natural selection. There is trenchant analysis of some of the parallels proposed in this connection between the biological and the social sciences. In the (...) chapter on imperfect rationality the crucial notion is that of 'binding oneself', as Ulysses did before setting out to the Sirens, when weakness of will may prevent us from using our capacity for perfect rationality. The second half of the book deals with rational-actor theory, comparing its logical power and success to rival approaches, and with the varieties of irrationality expressed in contradictory beliefs and desires. (shrink)

In this volume, first published in 1983, Jon Elster approaches the study of technical change from an epistemological perspective.

Traces the depiction of biological science in mass media and how it has shaped public perceptions.

An interview exploring the complexity of contemporary French philosophical atheism, in the light of Difficult Atheism: Post-Theological Thinking in Badiou, Nancy and Meillassoux (Edinburgh UP, 2011).

A logic of grounding where what is grounded can be a collection of truths is a “many-many” logic of ground. The idea that grounding might be irreducibly many-many has recently been suggested by Dasgupta. In this paper I present a range of novel philosophical and logical reasons for being interested in many-many logics of ground. I then show how Fine’s State-Space semantics for the Pure Logic of Ground can be extended to the many-many case, giving rise to the Pure Logic (...) of Many-Many Ground. In the second, more technical, part of the paper, I do two things. First, I present an alternative formalization of plg; this allows us to simplify Fine’s completeness proof for plg. Second, I formalize plmmg using an infinitary sequent calculus and prove that this formalization is sound and complete. (shrink)

The question Jon Elster addresses in this challenging book is what binds societies together and prevents them from disintegrating into chaos and war. He analyses two concepts of social order: stable, predictable patterns of behaviour, and co-operative behaviour. The book examines various aspects of collective action and bargaining from the perspective of rational-choice theory and the theory of social norms. It is a fundamental assumption of the book that social norms provide an important kind of motivation for action that is (...) irreducible to rationality. The book represents a major statement by Elster, which will be of particular interest to political scientists, political philosophers, sociologists, and economists. (shrink)

Science is widely perceived as an especially systematic approach to knowing; engineering could be conceived as an especially systematic approach to willing. The transcendental precepts of Bernard Lonergan may be adapted to provide the backdrop for this assessment, which is manifest when the scientific and engineering methods are compared. In science, although the will is implicitly involved, the intellect is primary, because the goal is ideal—additional “objective” knowledge. In engineering, although the intellect is implicitly involved, the will is primary, because (...) the goal is pragmatic—some “subjective” outcome, which is often selected by a manager or client, rather than the engineer. Furthermore, engineering problems are rarely well-defined; uncertainties and resource constraints dictate that they be conceptualized and solved heuristically. As a result, different engineers will follow different design procedures and develop different models, none of which is uniquely “correct.” Because tradeoffs are always necessary, engineering decision-making—and human behavior in general—is more intentional than rational. Recognizing this can help today’s society to overcome its traditional bias in favor of knowing over willing and to engage engineers more explicitly in addressing the many challenges that it faces, technological and otherwise. (shrink)

I, player : the puzzle of personal identity (MMORPGS and Virtual Communities) -- The game inside the mind, the mind inside the game (The Nintendo Wii Gaming Console) -- Realistic blood and gore : do violent games make violent gamers? (First-person Shooters) -- Games and God's goodness (World-builder and Tycoon Games) -- The metaphysics of interactive art (Puzzle and Adventure Games) -- Artificial and human intelligence (Single-player RPGS) -- Epilogue: Video games and the meaning of life.

In the early 1990s there emerged a growing interest with the concept of epistemic entitlement. Philosophers who acknowledge the existence of entitlements maintain that there are beliefs or judgments unsupported by evidence available to the subject, but which the subject nonetheless has the epistemic right to hold. Some of these may include beliefs non-inferentially sourced in perception, memory, introspection, testimony, and the a priori. Unlike the traditional notion of justification, entitlement is often characterized as an externalist type of epistemic warrant, (...) in the sense that a subject’s being entitled is determined by facts and circumstances that are independent of any reasoning capacities she may or may not have, and which the subject herself need not understand or be able to recognize. One key motivation for this view is that the inclusion of entitlement in epistemology can account for the commonly held intuition that largely unreflective individuals, such as children and non-human animals, possess warrant and basic knowledge about the world. It also paves the way for a tenable foundationalist epistemology, according to which there exist warranted beliefs which are not themselves warranted or justified by any further beliefs. This article explores theories of entitlement as presented by four prominent philosophers: Fred Dretske, Tyler Burge, Crispin Wright, and Christopher Peacocke. (shrink)

This is the first major study of Michel Foucault as a political thinker. Written in clear prose, Foucault and the Political explores the ramifications for political theory of the whole range of Foucault's writing, including materials only recently made available. Jon Simons argues that Foucault's work is animated by a tension between his presentation of modern life as "unbearably heavy" and his temptation to escape its limitations by aiming for "unbearable lightness." Through expositions of Foucault's ideas on power/knowledge, subjectification, governmentality, (...) political rationality and the aesthetics of existence, Simons demonstrates how Foucault resists both extremes. Foucault's thought entails an ethic of permanent resistance, best embodied in radical democracy. Simons relates Foucault's work both to contemporary political thinkers, such as Michael Walzer, Charles Taylor and Jurgen Habermas, as well as to scholars challenging conventional political categories, especially feminist and gay theorists such as Judith Butler. (shrink)

Despite great advances in recent scholarship on the political philosophy of John Rawls, Rawls’s conception of stability is not fully appreciated. This essay aims to remedy this by articulating a more complete understanding of stability and its role in Rawls’s theory of justice. I argue that even in A Theory of Justice Rawls maintains that within liberal democratic constitutionalism judgments of relative stability typically adjudicate decisively among conceptions of justice and is committed to more deeply than to the substantive content (...) of justice as fairness. This essay thus emphasizes the continuity of Rawls’s thought over time and motivates the position that Rawlsian stability is as philosophically significant and distinctively Rawlsian as justice as fairness itself. (shrink)

El artículo trata de acometer una aproximación intelectual al concepto de teoría conspirativa, a fin de explorar tentativamente posibles cartografías para una adecuada comprensión de su significatividad y pregnancia contemporáneas. Para ello, se procederá a un somero repaso de las aportaciones recientes al estudio de las teorías conspirativas desde una pluralidad de disciplinas (estudios culturales, teoría política, psicoanálisis, psicología social o filosofía) y a una exploración de sus mecanismos de funcionamiento y sus posibles funciones dentro del campo de fuerzas configurado (...) alrededor de la relación existente entre neoliberalismo y populismo. Finalmente, se propone una concepción de la teoría conspirativa contemporánea como una forma de teodicea, en cuanto a que cumple funciones de explicación del mal y de desplazamiento de la responsabilidad. (shrink)

God is for you -- We know God when we take a step of faith -- We know God when we know Jesus -- We know God when we experience his grace -- We know God when he gives us his holy spirit -- We know God when we see reality -- We know God when we begin a relationship -- We know God when we are redeemed -- We know God when we live like Jesus -- We know God (...) when he comes for us. (shrink)

The study of intrapersonal economic relations, or economics , is still at the programmatic stage. There is no generally accepted paradigm, or even as well-defined set of problems that constitute it as a subdiscipline within economics. Some questions are, however, emerging as foci of interest for a small but increasing number of writers, not just in economics, but also in psychology and philosophy. The writings of Thomas Schelling on self-management, of George Ainslie on self-control, and of Derik Parfit on personal (...) identity testify to this convergence. (shrink)

Peirce is best known as the founder of pragmatism, but his dissatisfaction with how others understood and appropriated it prompted him to rename his own doctrine “pragmaticism” and to compose several variants of his original maxim defining it, as well as numerous restatements and elaborations. This paper presents an extensive selection of such formulations, followed by analysis and commentary demonstrating that for Peirce the ultimate meaning of an intellectual concept is properly expressed as a conditional proposition about the deliberate, self-controlled (...) conduct of its interpreters, not the law-governed behavior of its object. (shrink)

This volume of essays is very much a sequel to the two earlier collections by Jon Elster, Ulysses and the Sirens and Sour Grapes. His topic is rationality - its scope, its limitations, and its failures. Elster considers rational responses to the insufficiency of reason itself, and to the 'indeterminacies' in deploying rational-choice theory and discusses the irrationality of not seeing when, where, and what these are. A key essay which gives the collection its title examines disputes in cases of (...) child custody, which are paradigmatically indeterminate. Leaving aside cases where one parent is patently unfit and assuming that protracted dispute is against the immediate interests of the child, Elster argues that three options present themselves: a strong presumption in favour of the mother, a strong presumption in favour of the primary caretaker (also likely to be the mother), and tossing a coin. Though the first two options may be preferable in the short/medium term, Elster argues that there is a case for randomisation in the long term. The book will be read with interest by anyone concerned with political and social science. (shrink)

Common sense suggests that it is always preferable to have more options than fewer, and better to have more knowledge than less. This provocative book argues that, very often, common sense fails. Sometimes it is simply the case that less is more; people may benefit from being constrained in their options or from being ignorant. The three long essays that constitute this book revise and expand the ideas developed in Jon Elster's classic study Ulysses and the Sirens. It is not (...) simply a new edition of the earlier book, though; many of the issues merely touched on before are explored here in much more detail. Elster shows how seemingly disparate examples which limit freedom of action reveal similar patterns, so much so that he proposes a new field of study: constraint theory. The book is written in Elster's characteristically vivid style and will interest professionals and students in philosophy, political science, psychology, and economics. (shrink)