BackgroundIn Parkinson's disease, the side of motor symptoms onset may influence disease progression, with a faster motor symptom progression in patients with left side lateralization. Moreover, worse neuropsychological outcomes after subthalamic nucleus deep brain stimulation have been described in patients with predominantly left-sided motor symptoms. The objective of this study was to evaluate if the body side of motor symptoms onset may predict motor outcome of bilateral STN-DBS.MethodsThis retrospective study included all consecutive PD patients treated with bilateral STN-DBS at Grenoble (...) University Hospital from 1993 to 2015. Demographic, clinical and neuroimaging data were collected before and 1 year after surgery. The predictive factors of motor outcome at one-year follow-up, measured by the percentage change in the MDS-UPDRS-III score, were evaluated through univariate and multivariate linear regression analysis.ResultsA total of 233 patients were included with one-year follow-up after surgery [143 males ; 121 right body onset; 112 left body onset; mean age at surgery, 55.31 ± 8.44 years; mean disease duration, 11.61 ± 3.87]. Multivariate linear regression analysis showed that the left side of motor symptoms onset did not predict motor outcome.ConclusionsIn this retrospective study, the body side of motor symptoms onset did not significantly influence the one-year motor outcome in a large cohort of PD patients treated with bilateral STN-DBS. (shrink)

The Tattvapaplavasimha is a philosophical text unique of its kind it is the only text of the Carvaka Lokayata school which has survived and the only Sanskrit work in which full-fledged scepticism is propounded. Notwithstanding that it has been hitherto almost completely ignored. The present book consists of an introduction detailed analysis edition translation with extensive notes of the first half of the text. In the introduction Jayarasi`s affiliation to the Lokayata school is reassessed and his place in the historical (...) development of Indian Philosophy evaluated. New evidence for the dating of Jayarasi is examined and a new dating is suggested. (shrink)

In this detailed study of the republican tradition in the development of the Enlightenment, the central problem of utopia and reform is crystallized in a discussion of the right to punish. Describing the political situation in Europe in the seventeenth and eighteenth centuries, the author shows how the old republics in Italy, Poland and Holland stagnated and were unable to survive in the age of absolutism. The Philosophes discussed the ideal of republicanism against this background. They were particularly influenced by (...) the political and religious radicalism of John Toland, which had survived the English Restoration and was then reaching Europe. Professor Venturi traces the debate on the penal laws and the attempt to relate utopian ideas of society to the practical problem of dealing with man in society, which culminated in the assertion by many Philosophes that an unjust social system necessitated harsh penal laws, thereby rejecting the possibility of reform. (shrink)

"Die vorliegende Fassung des Textes wurde anhand des englischen Originalmanuskriptes von Franco Selleri unter Mitarbeit von Roman U. Sexl erstellt."--T.p. verso.

Uma reflexão sobre o currículo desde a perspectiva althusseriana, buscando criticar os dispositivos ideológicos presentes no contexto educacional.

Spingersi ai confini dell'esperienza del corpo - amore, sofferenza, vecchiaia, morte - attraverso la letteratura, la filosofia, le arti figurative, eventi etico-politici e personali, frammenti di racconto.

1. La filosofia antica-India, Cina, Grecia -- 2. La filosofia tardo-antica e medioevale: ebraismo, cristianesimo, islamismo -- 3.1. La filosofia moderna: umanesimo, Riforma, rivoluzione scientifica (1350-1715) -- 3.2. La filosofia moderna: illuminismo, criticismo, idealismo (1715-1815) -- 4.1. La filosofia contemporanea: scientismi, sroticismi, irrazionalismi -- 4.2. La filosofia contemporanea: filosofie analitiche e continentali.

Background:A growing number of frameworks for the practice of clinical ethics are described in the literature. Among these, hermeneutical frameworks have helped highlight the interpretive and contextual nature of clinical ethics practice.Objectives:The aim of this article is to further advance this body of work by drawing on the ideas of Charles Taylor, a leading hermeneutical philosopher.Design/Findings:A Hermeneutical Rapprochement Framework is presented for clinical ethics practice, based on Taylor’s hermeneutical “retrieval” and “rapprochement.” This builds on existing hermeneutical approaches for the practice (...) of clinical ethics by articulating a framework with interpretive and reconciliatory scope that extends beyond the presenting “local” context. A Hermeneutical Rapprochement Framework considers broader socio-historical horizons and imaginaries grounded on Taylor’s expansive work in epistemological, ontological, political, and moral philosophy.Discussion:The framework is discussed in terms of how it can be operationalized for clinical practice as well as normative development. Implications for the educational preparation of clinical ethicists are also discussed. Although this work is directly relevant for clinical ethicists, it can also help inform the ethical practice of all clinicians. (shrink)

The ground plan for the present volume is unique in Indological studies.

The integration of artificial intelligence into bioethics education represents a new pedagogical approach that addresses complex moral issues in healthcare. The use of AI-driven platforms like ChatGPT in bioethics education can enhance critical thinking and decision-making skills among students by providing a diverse range of perspectives and solutions. To assess the ability of ChatGPT-4 to understand and resolve ethical dilemmas using validated clinical case vignettes, thereby determining its suitability as a teaching aid in bioethics. Ten clinical scenarios, each with inherent (...) ethical issues, were presented to ChatGPT-4. These scenarios were expert-validated to ensure relevance and complexity. ChatGPT's responses were evaluated by two blinded external raters to eliminate bias. The assessment criteria included identification of bioethical principles, recognition of stakeholders and their outcomes, and comprehension of ethical and legal frameworks. Additionally, the quality of responses was scored on a scale of 1–10. ChatGPT showed proficiency in identifying the pertinent bioethical principles and stakeholders involved in the ethical dilemmas presented. It achieved an overall score of 84.5%, with high marks for its analytical capabilities in complex scenarios. However, the study identified areas for improvement, particularly in proposing comprehensive solutions and alternative actions. ChatGPT demonstrates potential as an effective tool for bioethics education, capable of guiding learners through the resolution of ethical issues in clinical practice. However, to fully integrate ChatGPT into bioethics education, it requires enhancements in delivering detailed, actionable guidance in ethical decision-making. Future development should focus on refining ChatGPT’s ability to offer nuanced solutions aligned with patient values and clinician needs. (shrink)

L’Autore di questo libro è noto per le sue vitrioliche critiche al web e in generale alla comunicazione elettronica. Ma questo libro è la prova che non si tratta di neo-luddismo, vale a dire di una opposizione a priori all’innovazione tecnologica. L’Autore semplicemente richiama il dovere di valutare le “ricadute” del progresso tecnico, sia sociali che psicologico-individuali. L’eccesso delle informazioni, rapide e varie, può determinare una grave de-concentrazione, ansia immotivata, disorientamento. In questo libro si indicano le condizioni per un progresso (...) tecnico non alienante, in cui l’equilibrio fra ragione ed emotività sia garantita, in vista di un nuovo umanesimo. (shrink)

O presente artigo pretende analisar o processo que, de acordo com Foucault, levou ao abandono da morte pelo poder durante a transição do poder soberano para o disciplinar, na virada do século XVIII para o século XIX. Para tanto, assumindo a perspectiva das práticas punitivas, privilegiada pelo lósofo francês, buscaremos compreender, primeiramente, o papel assumido pela morte na justiça soberana. Em seguida, acompanharemos as transformações nas táticas punitivas motivadas pela consolidação do capitalismo, no bojo das quais o encarceramento emerge como (...) forma de punição privilegiada. Em um terceiro passo, pretendemos identi car, sob essas modi cações nas técnicas de punição, transformações mais profundas nas relações entre o poder, o corpo e a vida, que implicam a desquali cação da morte pelo poder. Finalmente, e à guisa de conclusão, mostraremos que Foucault concebe um novo regime de presença da morte no seio do poder disciplinar. (shrink)

In this article I argue for an interpretive approach to bioethics with critically ill children. I begin by highlighting the dominant Anglo-American bioethical framework that defines standards for ethical care in critically ill children and then outline a critique of this framework. Drawing predominantly on the ideas of Charles Taylor, Michael Walzer and Richard Zaner, I call for a reconception of bioethics and propose an interpretive ‘thick’ framework that is centred on culture and context. Finally, I illustrate this interpretive approach (...) through a comparative study of two cases in pediatric intensive care: the narratives of Marc and Larry. These case studies reveal that ethical dilemmas in pediatric critical care can be traced to relational tensions over respect, trust and power rooted in the disparity of moral horizons among the persons involved. (shrink)

ABSTRACTThis paper analyses the discourses produced on their websites by the two organisations that conducted the official ‘leave’ and ‘remain’ campaigns in the Brexit referendum. The analysis, whi...

This analysis presents an epistemological and moral examination of suffering. It addresses the specific questions: (1) What is suffering? (2) Can one's suffering be assessed by another? and (3) What is the moral significance of suffering? The epistemological analysis is orientated by Peter Hacker's framework for the investigation of emotions, demonstrating that suffering is an emotion. This leads to a discussion of whether suffering is a phenomenon that can be evaluated objectively by another person who is not experiencing the suffering, (...) questioning the validity of some decisional models for limiting life-sustaining therapies with the aim of preventing suffering. This analysis highlights that understandings of suffering are value laden. It is conventionally implied that suffering is `bad' and that it should be eliminated. Suffering is commonly regarded as a moral wrong that needs to be made right by health care. This article concludes with a recommendation for a paradigm shift in how suffering can be better understood, through the practice of empathic attunement. (shrink)

We characterize the sets of all Π2 and all equation image theorems of IΠ−1 in terms of restricted exponentiation, and use these characterizations to prove that both sets are not deductively equivalent. We also discuss how these results generalize to n > 0. As an application, we prove that a conservation theorem of Beklemishev stating that IΠ−n + 1 is conservative over IΣ−n with respect to equation image sentences cannot be extended to Πn + 2 sentences. © 2011 WILEY-VCH Verlag (...) GmbH & Co. KGaA, Weinheim. (shrink)