Introduction As deep brain stimulation (DBS) has shifted to being used earlier during Parkinson’s disease (PD), data is lacking regarding patient specific attitudes, preferences, and factors which may influence the timing of and decision to proceed with DBS in the United States. This study aims to identify and compare attitudes and preferences regarding the earlier use of DBS in Parkinson’s patients who have and have not undergone DBS. Methods We developed an online survey concerning attitudes about DBS and its timing (...) in PD. The survey was distributed nationally in the United States via the Michael J. Fox Foundation Trial Finder, the American Parkinson Disease Association flyers, and as a link on the Parkinson Alliance website. Differences in responses between PD DBS and non-DBS patients were assessed. Results A total of 445 patients with PD met eligibility criteria for the survey of which 160 self-identified as having undergone DBS. Fifty-five percent (n = 124) of non-DBS patients believed that DBS for PD should only be considered after all medication options have been tried. Patients favoring early DBS had fewer concerns regarding the surgery than those favoring later DBS. Conclusion Our findings highlight a variety of important considerations and concerns patients have regarding DBS and its timing. These viewpoints are important aspects of shared decision-making, as they help to identify patients’ preferences, values, and goals, which should enable providers to better navigate, with their patients, the decision path for therapeutic options to consider. (shrink)

Hastings Center Report, Volume 52, Issue S1, Page S72-S78, March‐April 2022.

Because it promises to benefit business and society simultaneously, strategic philanthropy might be characterized as a “happy marriage” of corporate social responsibility behavior and corporate financial performance. However, as evidence so far has been mostly anecdotal, it is important to understand to what extent empirics support the actual practice as well as value of a strategic approach, which creates both business and social impacts through corporate philanthropic activities. Utilizing data from the years 2006 to 2009 for a sample of the (...) Dow Jones Sustainability Index, which monitors the world’s most sustainable companies, the authors test a model of strategic philanthropy in which the dependent variable is evidence that a firm does or does not measure business and social impacts simultaneously. From the DJSI data, the authors find a proposed measure of overall corporate social performance to be the most important explanatory factor for engagement in strategic philanthropy. Moreover, this measure of CSP has a mediating effect on the relations between certain independent variables and strategic philanthropy. Other important findings provide support for the influence of the institutional factors industry and region on the likelihood that companies are practicing strategic philanthropy, but little effect of the business characteristics company size and profitability on that likelihood. (shrink)

Drawing a framework from institutional and legitimacy theory, supplemented by concepts from the accounting literature, this study uses longitudinal crosssectional and cross-national data on over 500 firms listed in the Dow Jones Sustainability Index (DJSI) to empirically test whether these firms are strategic in their philanthropy as indicated by their measurement of the impact of their philanthropic activities along three dimensions -society, business, and reputation and stakeholder satisfaction. It is predicted that the variables' company size, amount of philanthropic expenditure, region (...) and industry influence the extent to which the various impact dimensions of philanthropy are measured. Though unexpected considering the lack of common practice in impact measurement, it is found that between 62 and 76% of the DJSI firms measure some sort of impact of their philanthropic activities, mostly impact on society and impact on reputation and stakeholder satisfaction. The number of firms that measure impact increases over the years and so does the number of firms that measure multiple dimensions of impact. Consist with our predictions, we find that larger firms and firms with relatively higher philanthropic expenditures are more likely to measure impact. Moreover, firms in the financial sector and firms from Europe and North America are also more likely to measure impact of their philanthropic activities. (shrink)

Identification of non-coding RNAs (ncRNAs) has been significantly enhanced due to the rapid advancement in sequencing technologies. On the other hand, semantic annotation of ncRNA data lag behind their identification, and there is a great need to effectively integrate discovery from relevant communities. To this end, the Non-Coding RNA Ontology (NCRO) is being developed to provide a precisely defined ncRNA controlled vocabulary, which can fill a specific and highly needed niche in unification of ncRNA biology.

Background To determine whether fetal care paediatric and maternal–fetal medicine specialists harbour differing attitudes about pregnancy termination for congenital fetal conditions, their perceived responsibilities to pregnant women and fetuses, and the fetus as a patient and whether self-perceived primary responsibilities to fetuses and women and views about the fetus as a patient are associated with attitudes about clinical care.Methods Mail survey of 434 MFM and FCP specialists .Results MFMs were more likely than FCPs to disagree with these statements : ‘the (...) presence of a fetal abnormality is not an appropriate reason for a couple to consider pregnancy termination’ ; ‘the effects that a child born with disabilities might have on marital and family relationships is not an appropriate reason for a couple to consider pregnancy termination’ ; and ‘the cost of healthcare for the future child is not an appropriate reason for a couple to consider pregnancy termination’ . 65% MFMs versus 47% FCPs disagreed that their professional responsibility is to focus primarily on fetal well-being . Specialists did not differ regarding the fetus as a separate patient. Responses about self-perceived responsibility to focus on fetal well-being were associated with clinical practice attitudes.Conclusions Independent of demographic and sociopolitical characteristics, FCPs and MFMs possess divergent ethical sensitivities regarding pregnancy termination, pregnant women and fetuses, which may influence clinical care. (shrink)

Identification of non-coding RNAs (ncRNAs) has been significantly improved over the past decade. On the other hand, semantic annotation of ncRNA data is facing critical challenges due to the lack of a comprehensive ontology to serve as common data elements and data exchange standards in the field. We developed the Non-Coding RNA Ontology (NCRO) to handle this situation. By providing a formally defined ncRNA controlled vocabulary, the NCRO aims to fill a specific and highly needed niche in semantic annotation of (...) large amounts of ncRNA biological and clinical data. (shrink)

In recent years, sequencing technologies have enabled the identification of a wide range of non-coding RNAs (ncRNAs). Unfortunately, annotation and integration of ncRNA data has lagged behind their identification. Given the large quantity of information being obtained in this area, there emerges an urgent need to integrate what is being discovered by a broad range of relevant communities. To this end, the Non-Coding RNA Ontology (NCRO) is being developed to provide a systematically structured and precisely defined controlled vocabulary for the (...) domain of ncRNAs, thereby facilitating the discovery, curation, analysis, exchange, and reasoning of data about structures of ncRNAs, their molecular and cellular functions, and their impacts upon phenotypes. The goal of NCRO is to serve as a common resource for annotations of diverse research in a way that will significantly enhance integrative and comparative analysis of the myriad resources currently housed in disparate sources. It is our belief that the NCRO ontology can perform an important role in the comprehensive unification of ncRNA biology and, indeed, fill a critical gap in both the Open Biological and Biomedical Ontologies (OBO) Library and the National Center for Biomedical Ontology (NCBO) BioPortal. Our initial focus is on the ontological representation of small regulatory ncRNAs, which we see as the first step in providing a resource for the annotation of data about all forms of ncRNAs. The NCRO ontology is free and open to all users. (shrink)

In their target article, Conley et al. (2023) appropriately highlight the ongoing conceptual and practical opacity of public engagement (PE) in the translation of human gene editing (HGE) (Conley e...

Thousands of youth suffering from acquired brain injury or other early-life neurological disease live, mature, and learn with only limited communication and interaction with their world. Such cognitively capable children are ideal candidates for brain-computer interfaces. While BCI systems are rapidly evolving, a fundamental gap exists between technological innovators and the patients and families who stand to benefit. Forays into translating BCI systems to children in recent years have revealed that kids can learn to operate simple BCI with proficiency akin (...) to adults. BCI could bring significant boons to the lives of many children with severe physical impairment, supporting their complex physical and social needs. However, children have been neglected in BCI research and a collaborative BCI research community is required to unite and push pediatric BCI development forward. To this end, the pediatric BCI Canada collaborative network was formed, under a unified goal to cooperatively drive forward pediatric BCI innovation and impact. This article reflects on the topics and discussions raised in the foundational BCI-CAN meeting held in Toronto, ON, Canada in November 2019 and suggests the next steps required to see BCI impact the lives of children with severe neurological disease and their families. (shrink)

Frameworks of emotional development have tended to focus on how environmental factors shape children's emotion understanding. However, individual experiences of emotion represent a complex interplay between both external environmental inputs and internal somatovisceral signaling. Here, we discuss the importance of afferent signals and coordination between central and peripheral mechanisms in affective response processing. We propose that incorporating somatovisceral theories of emotions into frameworks of emotional development can inform how children understand emotions in themselves and others. We highlight promising directions for (...) future research on emotional development incorporating this perspective, namely afferent cardiac processing and interoception, immune activation, physiological synchrony, and social touch. (shrink)

Although theories that examine direct links between behavior and brain remain incomplete, it is known that brain expansion significantly correlates with caloric and oxygen demands. Therefore, one of the principles governing evolutionary cognitive neuroscience is that cognitive abilities that require significant brain function (and/or structural support) must be accompanied by significant fitness benefit to offset the increased metabolic demands. One such capacity is self-awareness (SA), which (1) is found only in the greater apes and (2) remains unclear in terms of (...) both cortical underpinning and possible fitness benefit. In the current experiment, transcranial magnetic stimulation (TMS) was applied to the prefrontal cortex during a spatial perspective-taking task involving self and other viewpoints. It was found that delivery of TMS to the right prefrontal region disrupted self-, but not other-, perspective. These data suggest that self-awareness may have evolved in concert with other right hemisphere cognitive abilities. (shrink)

Research has indicated that microRNAs (miRNAs), a special class of non-coding RNAs (ncRNAs), can perform important roles in different biological and pathological processes. miRNAs’ functions are realized by regulating their respective target genes (targets). It is thus critical to identify and analyze miRNA-target interactions for a better understanding and delineation of miRNAs’ functions. However, conventional knowledge discovery and acquisition methods have many limitations. Fortunately, semantic technologies that are based on domain ontologies can render great assistance in this regard. In our (...) previous investigations, we developed a miRNA domain-specific application ontology, Ontology for MIcroRNA Target (OMIT), to provide the community with common data elements and data exchange standards in the miRNA research. This paper describes (1) our continuing efforts in the OMIT ontology development and (2) the application of the OMIT to enable a semantic approach for knowledge capture of miRNA-target interactions. (shrink)

In recent years, sequencing technologies have enabled the identification of a wide range of non-coding RNAs (ncRNAs). Unfortunately, annotation and integration of ncRNA data has lagged behind their identification. Given the large quantity of information being obtained in this area, there emerges an urgent need to integrate what is being discovered by a broad range of relevant communities. To this end, the Non-Coding RNA Ontology (NCRO) is being developed to provide a systematically structured and precisely defined controlled vocabulary for the (...) domain of ncRNAs, thereby facilitating the discovery, curation, analysis, exchange, and reasoning of data about structures of ncRNAs, their molecular and cellular functions, and their impacts upon phenotypes. The goal of NCRO is to serve as a common resource for annotations of diverse research in a way that will significantly enhance integrative and comparative analysis of the myriad resources currently housed in disparate sources. It is our belief that the NCRO ontology can perform an important role in the comprehensive unification of ncRNA biology and, indeed, fill a critical gap in both the Open Biological and Biomedical Ontologies (OBO) Library and the National Center for Biomedical Ontology (NCBO) BioPortal. Our initial focus is on the ontological representation of small regulatory ncRNAs, which we see as the first step in providing a resource for the annotation of data about all forms of ncRNAs. (shrink)

Interest in science and math plays an important role in encouraging STEM motivation and career aspirations. This interest decreases for girls between late childhood and adolescence. Relatedly, positive mentoring experiences with female teachers can protect girls against losing interest. The present study examines whether visitors to informal science learning sites differ in their expressed science and math interest, as well as their science and math stereotypes following an interaction with either a male or female educator. Participants were visitors to one (...) of four ISLS in the United States and United Kingdom. Following an interaction with a male or female educator, they reported their math and science interest and responded to math and science gender stereotype measures. Female participants reported greater interest in math following an interaction with a female educator, compared to when they interacted with a male educator. In turn, female participants who interacted with a female educator were less likely to report male-biased math gender stereotypes. Self-reported science interest did not differ as a function of educator gender. Together these findings suggest that, when aiming to encourage STEM interest and challenge gender stereotypes in informal settings, we must consider the importance of the gender of educators and learners. (shrink)

The Protein Ontology (PRO; http://proconsortium.org) formally defines protein entities and explicitly represents their major forms and interrelations. Protein entities represented in PRO corresponding to single amino acid chains are categorized by level of specificity into family, gene, sequence and modification metaclasses, and there is a separate metaclass for protein complexes. All metaclasses also have organism-specific derivatives. PRO complements established sequence databases such as UniProtKB, and interoperates with other biomedical and biological ontologies such as the Gene Ontology (GO). PRO relates to (...) UniProtKB in that PRO’s organism-specific classes of proteins encoded by a specific gene correspond to entities documented in UniProtKB entries. PRO relates to the GO in that PRO’s representations of organism-specific protein complexes are subclasses of the organism-agnostic protein complex terms in the GO Cellular Component Ontology. The past few years have seen growth and changes to the PRO, as well as new points of access to the data and new applications of PRO in immunology and proteomics. Here we describe some of these developments. (shrink)

In this book, leading Christian political thinkers and practitioners critique the Rawlsian concepts of “justice as fairness” and “public reason” from the perspective of Christian political theory and practice. It provides a new level of analysis from Christian perspectives, including implications for such hot topics as the culture war.

Cancer and its treatment pose challenges that affect not only patients but also their significant others, including intimate partners. Accumulating evidence suggests that couples’ ability to communicate effectively plays a major role in the psychological adjustment of both individuals and the quality of their relationship. Two key conceptual models have been proposed to account for how couple communication impacts psychological and relationship adjustment: the social-cognitive processing (SCP) model and the relationship intimacy (RI) model. These models posit different mechanisms and outcomes, (...) and thus have different implications for intervention. The purpose of this project is to test and compare the utility of these models using comprehensive and methodologically rigorous methods. Aims are: (1) to examine the overall fit of the SCP and RI models in explaining patient and partner psychological and relationship adjustment as they occur on a day-to-day basis and over the course of 1 year; (2) to examine the fit of the models for different subgroups (males vs. females, and patients vs. partners); and (3) to examine the utility of various methods of assessing communication by examining the degree to which baseline indices from different measurement strategies predict self-reported adjustment at 1-year follow up. The study employs a longitudinal, multi-method approach to examining communication processes including: standard self-report questionnaires assessing process and outcome variables collected quarterly over the course of 1 year; smartphone-based ecological momentary assessments to sample participant reports in real time; and laboratory-based couple conversations from which we derive observational measures of communicative behavior and affective expression, as well as vocal indices of emotional arousal. Participants are patients with stage II-IV breast, colon, rectal, or lung cancer and their spouses/partners, recruited from two NCI-designated comprehensive cancer centers. Results will be published in scientific journals, presented at scientific conferences, and conveyed to a larger audience through infographics and social media outlets. Findings will inform theory, measurement, and the design and implementation of efficacious interventions aimed at optimizing both patient and partner well-being. (shrink)

Challenging the undesirability of disability is a shared responsibility that requires us to imagine disability differently. In order to imagine disability differently, we need to understand how the neoliberal hegemonic social imagination—key to processes that create good disabled and able-bodied neoliberal subjects—works to curtail who is perceived to have a desirable body. In order to desire disability differently, we must begin with marginal, heterotopic imaginations whereby disability is not something to overcome, but rather is part of a life worth living. (...) In this article, I build on Foucault’s concepts of heterotopia, milieu, and the government of things, and Karen Barad’s agential realism, as well as draw on the work of Mel Chen and Rod Michalko in order to argue that the heterotopic imagination reconfigures how we consider disability to emerge, with whom, and where. By mobilising the heterotopic imagination, we can come to recognise that disability does not emerge as an individualised human body, but rather is an intracorporeal, non-anthropocentric multiplicity. To desire disability differently through the heterotopic imagination is not simply to allow the current formulation of disability to become desirable, but rather to radically alter how we desire disability, in addition to altering what disability is, how it is practised, and what it can be. (shrink)

This article explores the representational practices of feminist theorising around gender and violence. Adapting Liz Kelly’s notion of the continuum of women’s experiences of sexual violence, I argue that ‘continuum thinking’ can offer important interventions which unsettle binaries, recognise grey areas in women’s experiences and avoid ‘othering’ specific communities. Continuum thinking allows us to understand connections whilst nevertheless maintaining distinctions that are important conceptually, politically and legally. However, this is dependent upon recognising the multiplicity of continuums in feminist theorising (...) – as well as in policy contexts – and the different ways in which they operate. A discussion of contemporary theory and policy suggests that this multiplicity is not always recognised, resulting in a flattening of distinctions which can make it difficult to recognise the specifically gendered patterns of violence and experience. I conclude by considering how focusing on men’s behaviour might offer one way of unsettling the contemporary orthodoxy which equates gender-based violence and violence against women. (shrink)

While Karen Warren offers an ecofeminist ethic that is pluralistic, contextualist, and challenges Cartesian dualism, one area that remains underdeveloped in her theory is embodiment. I will examine Merleau-Ponty’s notion of embodied subjectivity and show that it would fit consistently with her theory. I will also explore some other areas in which the two theories supplement each other.

Discussion of partial grounds that aren't parts of full grounds; definition of full grounding in terms of partial grounding.

In lieu of an abstract, here is a brief excerpt of the content:“A Candle in Sunshine”Desire and Apocalypse in Blake and HölderlinMichael Kirwan, SJ (bio)Introduction1René Girard, in the wake of the critical theorists Adorno and Horkheimer, offers “an analysis of the present epoch.” His work can be seen as a further attempt to articulate the “dialectic of Enlightenment”: to explore precisely why, despite the hopes invested in the possibilities of human emancipation, the “enlightened world radiates disaster triumphant.” Like them, (...) Girard seeks to diagnose the present age and its Siamese twinning of emancipatory knowledge and barbarism.He does so by invoking messianic religious themes, notably the biblical theological category of apocalypse.2 In Battling to the End—by Girard’s own admission, a “bizarre book”—the apocalypse has quite specific geographical and historical coordinates. The hypermimetic rivalry between France and Germany that escalates through the nineteenth century reaches a symbolic tipping point in Hegel’s fascinated interpretation of Napoleon Bonaparte’s intervention at Jena in 1806—a fascination shared by Carl von Clausewitz (1780–1831), Prussian military theorist and author of the unfinished treatise On War. Girard thinks through Clausewitz’s appalled realization of the special nature of this [End Page 179] conflict: namely, that the intense “escalation to extremes” that ensnares these two protagonists will prove capable of overwhelming the “sacrificial” function of warfare. In other words, war will no longer have the capacity for channeling and containing conflict within strictly codified parameters. Click for larger view View full resolutionThe Last Judgement (1808) by William Blake (1757–1827), The Egremont Collection (accepted in lieu of tax by H.M. Treasury in 1957 and subsequently transferred to the National Trust). © NTPL/John Hammond[End Page 180]Following this logic, Girard argues that the total mobilization of populations begun with the French revolutionary army has indeed escalated, into the nightmarish catastrophes engulfing Europe and the world in the last century, which we now experience in the form of a global and globalized “war on terror”—a “global civil war.” Robert Hamerton-Kelly understands the situation as apocalyptic, defined as “an interpretation of politics in the form of a coded narrative.”3 Drawing on the root meaning of apokalypsis as “unveiling” or “disclosure,” he declares that ”something is being revealed about our world order, whether by divine grace or human reason,”4 a revelation that not only documents the threat to order but is itself a cause of the instability.Whether this heightened sense of history and its convulsions constitutes a significant change in mimetic theory, an “apocalyptic turn,” is open to debate. Hamerton-Kelly reminds us that Girard’s writing has been apocalyptic from the outset: witness Girard’s discussion of “The Dostoyevskian Apocalypse” in his first book. In his other main works, Girard has developed “an apocalyptic anthropology” that unveils the sacred structure of “this world.” This is apocalypse, but with a twist:Mimetic theory is ironically apocalyptic, because it is the opposite of what normally passes for that genre. It is nonviolent, while the vulgar apocalypse is violent, it decodes while the vulgar encodes, nevertheless, it is apocalyptic because it deals with universal history and human nature and assumes that historiography is possible and the human story is not “a tale told by an idiot.” It is apocalyptic because it decodes the encryption of violence in the vulgar apocalypse, in symbols such as the divine judgement and the torture of the guilty.5Bringing this context to light is less a matter of archaeology as of astrophysics: here, as it were, is modernity’s “big bang,” the point of origin of the matter and anti-matter of resentful energy that now threatens to overwhelm us.6 Girard’s reading offers much for the historian to grapple with, and yet it calls for more than historical analysis. In addition to Hegel and Clausewitz, Girard summons a further witness, Friedrich Hölderlin (1770–1843), a “theological poet” or Dichter, whose life and verse are read as a further commentary on the turbulent opening decade of the nineteenth century. The aim of the present article is to elucidate this poetical-theological dimension of Girard’s argument, partly by highlighting Girard’s invocation of Hölderlin, but also... (shrink)

In lieu of an abstract, here is a brief excerpt of the content:“A Candle in Sunshine”Desire and Apocalypse in Blake and HölderlinMichael Kirwan, SJ (bio)Introduction1René Girard, in the wake of the critical theorists Adorno and Horkheimer, offers “an analysis of the present epoch.” His work can be seen as a further attempt to articulate the “dialectic of Enlightenment”: to explore precisely why, despite the hopes invested in the possibilities of human emancipation, the “enlightened world radiates disaster triumphant.” Like them, (...) Girard seeks to diagnose the present age and its Siamese twinning of emancipatory knowledge and barbarism.He does so by invoking messianic religious themes, notably the biblical theological category of apocalypse.2 In Battling to the End—by Girard’s own admission, a “bizarre book”—the apocalypse has quite specific geographical and historical coordinates. The hypermimetic rivalry between France and Germany that escalates through the nineteenth century reaches a symbolic tipping point in Hegel’s fascinated interpretation of Napoleon Bonaparte’s intervention at Jena in 1806—a fascination shared by Carl von Clausewitz (1780–1831), Prussian military theorist and author of the unfinished treatise On War. Girard thinks through Clausewitz’s appalled realization of the special nature of this [End Page 179] conflict: namely, that the intense “escalation to extremes” that ensnares these two protagonists will prove capable of overwhelming the “sacrificial” function of warfare. In other words, war will no longer have the capacity for channeling and containing conflict within strictly codified parameters. Click for larger view View full resolutionThe Last Judgement (1808) by William Blake (1757–1827), The Egremont Collection (accepted in lieu of tax by H.M. Treasury in 1957 and subsequently transferred to the National Trust). © NTPL/John Hammond[End Page 180]Following this logic, Girard argues that the total mobilization of populations begun with the French revolutionary army has indeed escalated, into the nightmarish catastrophes engulfing Europe and the world in the last century, which we now experience in the form of a global and globalized “war on terror”—a “global civil war.” Robert Hamerton-Kelly understands the situation as apocalyptic, defined as “an interpretation of politics in the form of a coded narrative.”3 Drawing on the root meaning of apokalypsis as “unveiling” or “disclosure,” he declares that ”something is being revealed about our world order, whether by divine grace or human reason,”4 a revelation that not only documents the threat to order but is itself a cause of the instability.Whether this heightened sense of history and its convulsions constitutes a significant change in mimetic theory, an “apocalyptic turn,” is open to debate. Hamerton-Kelly reminds us that Girard’s writing has been apocalyptic from the outset: witness Girard’s discussion of “The Dostoyevskian Apocalypse” in his first book. In his other main works, Girard has developed “an apocalyptic anthropology” that unveils the sacred structure of “this world.” This is apocalypse, but with a twist:Mimetic theory is ironically apocalyptic, because it is the opposite of what normally passes for that genre. It is nonviolent, while the vulgar apocalypse is violent, it decodes while the vulgar encodes, nevertheless, it is apocalyptic because it deals with universal history and human nature and assumes that historiography is possible and the human story is not “a tale told by an idiot.” It is apocalyptic because it decodes the encryption of violence in the vulgar apocalypse, in symbols such as the divine judgement and the torture of the guilty.5Bringing this context to light is less a matter of archaeology as of astrophysics: here, as it were, is modernity’s “big bang,” the point of origin of the matter and anti-matter of resentful energy that now threatens to overwhelm us.6 Girard’s reading offers much for the historian to grapple with, and yet it calls for more than historical analysis. In addition to Hegel and Clausewitz, Girard summons a further witness, Friedrich Hölderlin (1770–1843), a “theological poet” or Dichter, whose life and verse are read as a further commentary on the turbulent opening decade of the nineteenth century. The aim of the present article is to elucidate this poetical-theological dimension of Girard’s argument, partly by highlighting Girard’s invocation of Hölderlin, but also... (shrink)

Through a series of linked studies, this text provides a wide-ranging analysis of the meeting of two vital themes in the French Revolutionary period.

For decades, aesthetics has been subjected to a variety of critiques, often concerning its treatment of beauty or the autonomy of art. Collectively, these complaints have generated an anti-aesthetic stance prevalent in the contemporary art world. Yet if we examine the motivations for these critiques, Michael Kelly argues, we find theorists and artists hungering for a new kind of aesthetics, one better calibrated to contemporary art and its moral and political demands. Following an analysis of the work of Stanley (...) Cavell, Arthur Danto, Umberto Eco, Susan Sontag, and other philosophers of the 1960s who made aesthetics more responsive to contemporary art, Kelly considers Sontag's aesthetics in greater detail. In _On Photography_ (1977), she argues that a photograph of a person who is suffering only aestheticizes the suffering for the viewer's pleasure, yet she insists in _Regarding the Pain of Others_ (2003) that such a photograph can have a sustainable moral-political effect precisely because of its aesthetics. Kelly considers this dramatic change to be symptomatic of a cultural shift in our understanding of aesthetics, ethics, and politics. He discusses these issues in connection with Gerhard Richter's and Doris Salcedo's art, chosen because it is often identified with the anti-aesthetic, even though it is clearly aesthetic. Focusing first on Richter's Baader-Meinhof series, Kelly concludes with Salcedo's enactments of suffering caused by social injustice. Throughout _A Hunger for Aesthetics_, he reveals the place of critique in contemporary art, which, if we understand aesthetics as critique, confirms that it is integral to art. Meeting the demand for aesthetics voiced by many who participate in art, Kelly advocates for a critical aesthetics that confirms the limitless power of art. (shrink)

According to Margaret Cavendish the entire natural world is essentially rational such that everything thinks in some way or another. In this paper, I examine why Cavendish would believe that the natural world is ubiquitously rational, arguing against the usual account, which holds that she does so in order to account for the orderly production of very complex phenomena (e.g. living beings) given the limits of the mechanical philosophy. Rather, I argue, she attributes ubiquitous rationality to the natural world in (...) order to ground a theory of the ubiquitous freedom of nature, which in turn accounts for both the world's orderly and disorderly behavior. (shrink)

No longer is pregnancy a repulsive or shameful condition in Hollywood films, but an attractive attribute, often enhancing the romantic or comedic storyline of a female character. Kelly Oliver investigates this curious shift and its reflection of changing attitudes toward women's roles in reproduction and the family. Not all representations signify progress. Oliver finds that in many pregnancy films, our anxieties over modern reproductive practices and technologies are made manifest, and in some cases perpetuate conventions curtailing women's freedom. Reading (...) such films as _Where the Heart Is_ (2000), _Riding in Cars with Boys_ (2001), _Palindromes_ (2004), _Saved!_ (2004), _Quinceañera_ (2006), _Children of Men_ (2006), _Knocked Up_ (2007), _Juno_ (2007), _Baby Mama_ (2008), _Away We Go_ (2009), _Precious_ (2009), _The Back-up Plan_ (2010), _Due Date_ (2010), and _Twilight: Breaking Dawn_ (2011), Oliver investigates pregnancy as a vehicle for romance, a political issue of "choice," a representation of the hosting of "others," a prism for fears of miscegenation, and a screen for modern technological anxieties. (shrink)

The moral/conventional task has been widely used to study the emergence of moral understanding in children and to explore the deficits in moral understanding in clinical populations. Previous studies have indicated that moral transgressions, particularly those in which a victim is harmed, evoke a signature pattern of responses in the moral/conventional task: they are judged to be serious, generalizable and not authority dependent. Moreover, this signature pattern is held to be pan‐cultural and to emerge early in development. However, almost all (...) the evidence for these claims comes from studies using harmful transgressions of the sort that primary school children might commit in the schoolyard. In a study conducted on the Internet, we used a much wider range of harm transgressions, and found that they do not evoke the signature pattern of responses found in studies using only schoolyard transgressions. Paralleling other recent work, our study provides preliminary grounds for skepticism regarding many conclusions drawn from earlier research using the moral/conventional task. (shrink)

Theological basis -- Religion and health care -- The dignity of human life -- The integrity of the human person -- Implications for health care -- Theological principles in health care ethics -- Method -- The levels and questions of ethics -- Freedom and the moral agent -- Right and wrong -- Metaethics -- Method in Catholic bioethics -- Catholic method and birth control -- The principle of double effect -- Application -- Forgoing treatment, pillar one: ordinary and extraordinary means (...) -- Forgoing treatment, pillar two: killing and allowing to die -- Forgoing treatment, pillar three: decisions by competent patients -- Forgoing treatment, pillar three: decisions for incompetent patients -- Forgoing treatment, pillar three: advance directives -- Hydration and nutrition -- Physician-assisted suicide and euthanasia -- Medical futility -- Pain and pain management -- Ethics committees -- Embryonic stem cells and the beginning of human personhood -- Genetic engineering -- Allocating health care resources -- The use and misuse of the allocation argument. (shrink)

Between 1653 and 1655 Margaret Cavendish makes a radical transition in her theory of matter, rejecting her earlier atomism in favour of an infinitely-extended and infinitely-divisible material plenum, with matter being ubiquitously self-moving, sensing, and rational. It is unclear, however, if Cavendish can actually dispense of atomism. One of her arguments against atomism, for example, depends upon the created world being harmonious and orderly, a premise Cavendish herself repeatedly undermines by noting nature’s many disorders. I argue that her supposed difficulties (...) with atomism expose a deeper tension in her work between two fundamental metaphysical commitments each of which has substantial philosophical support: her monist theory of the material world (which maintains that there exists just one natural substance which is the single principal cause) and her occasional theory of causation (which requires multiple finite principal causes in nature -- causes that might be considered individual substances). Her monism undermines atomism while her theory of occasional cause seems to rest on a conception of nature that would be especially friendly to atomism. I argue further that we can solve this tension within a Cavendishian framework in such a way as to preserve her theory of causation and her monism, but that this solution depends upon our taking her monism in a particular (and weak) form. I finally note that we can best make sense of her unique and interesting form of monism by acknowledging her social-political motivations in addition to her motivations in natural philosophy. (shrink)

The number of homebound individuals in the United States is on the rise, causing health-care professionals to expand in-home health services to help meet the increased demand. Due to the prevalence of feelings of isolation and depression in this population, it is imperative that mental health professionals join this effort to increase access to mental health services. Delivering psychotherapy in clients’ homes presents many advantages to these homebound individuals, but there is a dearth of literature addressing how therapists should handle (...) unique ethical issues that arise in this type of setting. This article addresses ethical considerations and guidelines for in-home provision of mental health services. General ethical issues related to home-based psychotherapy include boundaries, confidentiality and privacy, competency, insurance coverage, and autonomy. Issues pertaining to different categories of homebound individuals, including persons with agoraphobia, chronic illnesses, and older adults, are then discussed in turn. Recommendations on how to best manage these issues by applying the American Psychological Association’s, the American Counseling Association’s, and the National Association of Social Workers’ Ethics Codes are provided. (shrink)