IntroductionParkinson’s disease patients have a significantly higher risk of developing dementia in later disease stages, leading to severe impairments in quality of life and self-functioning. Questions remain on how deep brain stimulation affects cognition, and whether we can individualize therapy and reduce the risk for adverse cognitive effects. Our aim in this systematic review is to assess the current knowledge in the field and determine if the findings could influence clinical practice.MethodsWe have conducted a systematic review according to PRISMA guidelines (...) through MEDLINE and Embase databases, with studies being selected for inclusion via a set inclusion and exclusion criteria.ResultsSixty-seven studies were included in this systematic review according to the selected criteria. This includes 6 meta-analyses, 18 randomized controlled trials, 17 controlled clinical trials, and 26 observational studies with no control arms. The total number of PD patients encompassed in the studies cited in this review is 3677, not including the meta-analyses.ConclusionCognitive function in PD patients can deteriorate, in most cases mildly, but still impactful to the quality of life. The strongest evidence is present for deterioration in verbal fluency, while inconclusive evidence is still present for executive function, memory, attention and processing speed. Global cognition does not appear to be significantly impacted by DBS, especially if cognitive screening is performed prior to the procedure, as lower baseline cognitive function is connected to poor outcomes. Further randomized controlled studies are required to increase the level of evidence, especially in the case of globus pallidus internus DBS, pedunculopontine nucleus DBS, and the ventral intermediate nucleus of thalamus DBS, and more long-term studies are required for all respective targets. (shrink)

The Bertold Brecht's conception of the theater is not radically opposed to that of Aristotle. Brechtian aesthetics is, in many aspects, heiress of Aristotle's ideas. The epic theater proposed by Brecht opposes naturalistic theater and psychological drama. Mimesis and catharsis don't mean the identification of the public with the scene and the hero.A concepção teatral de Brecht não é radicalmente oposta à de Aristóteles. A estética brechtiana, em muitos aspectos, é herdeira das idéias de Aristóteles. O teatro épico proposto (...) por Brecht tem em seu horizonte de combate o teatro de matriz naturalista e o drama psicológico. Mimese e catarse não significam identificação do público com a cena e com o herói. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Explication or Explanation?Giovanni Stanghellini (bio) and Mario Rossi Monti (bio)Keywordsexplanation, explication, interpretation, phenomenology, psychopathologyMike Martin's paper raises questions about the process and the effectiveness of psychotherapy in the case of an Iraq war veteran, Colin, described by Dr. Bailey in his essay “A Painful Lack of Wounds”: does psychotherapy succeed? If so, why does it succeed? How far is and should psychotherapy be value free? The clinical phenomenon (...) discussed in this paper is defined as a serious but not severe depression occurring upon returning from the Iraq war. The impression, from the vantage point of a psychotherapist, is that too many details are lacking from the account that is provided and that the case is hurriedly explained away invoking a naturalistic evolutionary model.The psychotherapeutic, as well as the clinical (Stanghellini 2007) and the research (Stanghellini and Ballerini 2008) interview is a quest for meaning. Its first concern is an accurate unfolding of subjective experiences and the organization of these experiences according to a pattern of sense that is immanent to the experiences themselves; the interpretation or the explanation of these experiences according to a model that is not immanent in the clinical material itself may come as a later step.The first step may be called the explication of case material. It consists in bringing out the raw feelings of the patient's experiences and the personal meanings that the patient attributes to his experiences. Here is a list a questions that a clinician would (tactfully) address to Dr. Bailey's patient to enrich the clinical explication of this case (a great deal of questions, of course, can be found also in Martin's [2009] commentary): What are the phenomenal features of Colin's “depression”? Which thoughts and emotions are involved? Anxiety? Anguish? Fear? Frustration? Anger? Irritability? Sadness? Apathy? Guilt? Shame? Which other experiences are involved, for example, physical pains or somatic symptoms? What is it like for Colin not to have proven his “manhood” in Iraq? What does it mean for him to be a “man”? Why does he want to be a man? How does it look like his “ideal” man? How does he exactly feel and what does he mean by “being a wimp”?We also need to illuminate the internal relations of dependence between these experiences: are these phenomena each one independent form the others, or can we find a meaning organizer among them (Rossi Monti and Stanghellini 1996), for instance a core emotion that let us understand the manifold of symptoms as a unitary structure? Does Colin feel angry for not being assigned to a combat duty? Or guilty because he did not object to this? Or does he feel ashamed because he was judged not suitable for a combat duty? Apparently, there is a “basic” wound here, maybe a narcissistic one—the epicenter of a story that reminds us of Ajax's “madness” when the Greek generals did not offer [End Page 237] him Achilles’ weapons. Looking for this wound with Colin and through Colin's words is much different from endorsing an armchair theory of his “depression.” The latter reminds us of someone who feels full after reading the restaurant menu.We need to look for the relations between these clinical phenomena and the situation (event) in which they take place: what do we know about the pathogenetic situation? We know that the same person in different situations can behave and be valued in opposite ways. As Kretschmer pointed out, persons that in times of peace psychiatrists would label as psychopathic personalities in troubled times become celebrated heroes. In the same manner, a boy with an antisocial personality disorder can become a hero if he put his “qualities” to the service of military special forces. In particular, what did Colin expect from enrolling in the army? His expectations were his own or someone else's hopes? What happened exactly in Iraq? What does “Iraq” mean for the patient? What did he do and what did he not do to become a “man” or a hero there? Is Iraq the only place where someone can demonstrate to be a man? Is being a hero the only valuable way... (shrink)

L'autore parte dall'analisi dei problemi etici espressi nei linguaggi della poesia, della tragedia e della storiografia, per passare poi alla lettura delle maggiori opere del pensiero antico, fornendo di ognuna puntuali introduzioni. Un'attenzione particolare, alla fine di ogni capitolo, è dedicata all'eredità moderna e al significato attuale dei problemi dell'etica antica, proponendo in modo esplicito un collegamento fra ricostruzione storica e discussione teorica contemporanea.

Cómo es posible la historia? -- Giambattista Vico : Una nueva ciencia, la historia (1725) -- Carta de Heidelberg.

Most social scientists and philosophers claim that sociology and philosophy are disjoint fields of inquiry. Some have wondered how to trace the precise boundary between them. Mario Bunge argues that the two fields are so entangled with one another that no demarcation is possible or, indeed, desirable. In fact, sociological research has demonstrably philosophical pre-suppositions. In turn, some findings of sociology are bound to correct or enrich the philosophical theories that deal with the world, our knowledge of it, or (...) the ways of acting upon it. While Bunge's thesis would hardly have shocked Mill, Marx, Durkheim, or Weber, it is alien to the current sociological mainstream and dominant philosophical schools. Bunge demonstrates that philosophical problematics arise in social science research. A fertile philosophy of social science unearths critical presuppositions, analyzes key concepts, refines effective research strategies, crafts coherent and realistic syntheses, and identifies important new problems. Bunge examines Marx's and Durkheim's thesis that social facts are as objective as physical facts; the so-called Thomas theorem that refutes the behaviorist thesis that social agents react to social stimuli rather than to the way we perceive them; and Merton's thesis on the ethos of basic science which shows that science and morality are intertwined. He considers selected philosophical problems raised by contemporary social studies and argues forcefully against tolerance of shabby work in academic social science and philosophy alike. (shrink)

This fascinating exploration of the great discoveries of history's most important mathematicians seeks an answer to the eternal question: Does mathematics hold the key to understanding the mysteries of the physical world?

Machine generated contents note: I. METAPHYSICS -- 1. How Do Realism, Materialism, and Dialectics Fare in Contemporary Science? -- 2. New Dialogues between Hylas and Philonous -- 3. Energy: Between Physics and Metaphysics -- 4. The Revival of Causality -- 5. Emergence and the Mind -- 6 SCIENTIFIC REALISM -- 6. The Status of Concepts -- 7. Popper's Unworldly World 3 --II. METHODOLOGY AND PHILOSOPHY OF SCIENCE -- 8. On Method in the Philosophy of Science -- 9. Induction in Science (...) -- 10. The GST Challenge to the Classical Philosophies of Science -- 11. The Power and Limits of Reduction -- 12. Thinking in Metaphors --III. PHILOSOPHY OF MATHEMATICS -- 13. Moderate Mathematical Fictionism -- 14. The Gap between Mathematics and Reality -- 15. Two Faces and Three Masks of Probability --IV. PHILOSOPHY OF PHYSICS -- 16. Physical Relativity and Philosophy -- 17. Hidden Variables, Separability, and Realism -- 18. Schrodinger's Cat Is Dead --V. PHILOSOPHY OF PSYCHOLOGY -- 19. From Mindless Neuroscience and Brainless Psychology to Neuropsychology -- 20. Explaining Creativity -- VI. PHILOSOPHY OF SOCIAL SCIENCE -- 21. Analytic Philosophy of Society and Social Science: -- The Systemic Approach as an Alternative to Holism and Individualism -- 22. Rational Choice Theory: A Critical Look at Its Foundations -- 23. Realism and Antirealism in Social Science --VII. PHILOSOPHY OF TECHNOLOGY -- 24. The Nature of Applied Science and Technology -- 25. The Technology-Science-Philosophy Triangle in Its Social Context -- 26. The Technologies in Philosophy --VIII. MORAL PHILOSOPHY -- 27. A New Look at Moral Realism -- 28. Rights Imply Duties --IX. SOCIAL AND POLITICAL PHILOSOPHY -- 29. Morality Is the Basis of Legal and Political Legitimacy -- 30. Technoholodemocracy: An Alternative to -- Capitalism and Socialism -- Bibliography -- Index of Names -- Index of Subjects. (shrink)

A re-evaluation of the notion of vacuum in quantum electrodynamics is presented, focusing on the vacuum of the quantized electromagnetic field. In contrast to the ‘nothingness’ associated to the idea of classical vacuum, subtle aspects are found in relation to the vacuum of the quantized electromagnetic field both at theoretical and experimental levels. These are not the usually called vacuum effects. The view defended here is that the so-called vacuum effects are not due to the ground state of the quantized (...) electromagnetic field. Nevertheless it is possible to maintain an empirically demonstrable notion of vacuum state that is consistent with the interpretation of the formalism of the theory. (shrink)

Philosophies and phobosophies -- The philosophical matrix of scientific progress -- Systemics and materialism -- Technoscience? -- Climate and logic -- Informatics : one or multiple? -- Wealth and well-being, economic growth and integral development -- Can standard economic theory account for crises? -- Marxist philosophy : promise and reality -- Rules of law : just and unjust -- Subjective probabilities : admissible in science? -- Does inductive logic work? -- Bridging theories to data -- Matter and energy : physical (...) or metaphysical concepts? -- Does quantum physics refute realism, materialism and determinism? -- Parallel universes? Digital physics? -- Can functionalist psychology explain anything? -- Knowledge pyramids or rosettes? -- Existence : single or double? -- Conclusion : valuation criterion. (shrink)

The papers that follow were read and discussed at the first Symposium on Exact Philosophy. This conference was held at Montreal on November 4th and 5th, 1971, to celebrate the sesquicentennial of McGill University and establish the Society for Exact Philosophy. The expression 'exact philosophy' is taken to signify mathematical phi losophy, i.e., philosophy done with the explicit help of mathematical logic and mathematics. So far the expression denotes an attitude rather than a fully blown discipline: it intends to convey (...) the intention to try and pro ceed in as exact a manner as we can in formulating and discussing phi losophical problems and theories. The kind of philosophy we wish to practice and promote is disciplined rather than wild, systematic rather than disconnected, and capable of being argued over rather than oracular. We believe that even metaphysics, notoriously riotous, can be subjected to the control of logic and mathematics. Even the history of philosophy, notoriously unsystematic, can benefit from an exact reconstruction of some classical ideas. (shrink)

It is generally argued that if the wave-function in the de Broglie–Bohm theory is a physical field, it must be a field in configuration space. Nevertheless, it is possible to interpret the wave-function as a multi-field in three-dimensional space. This approach hasn’t received the attention yet it really deserves. The aim of this paper is threefold: first, we show that the wave-function is naturally and straightforwardly construed as a multi-field; second, we show why this interpretation is superior to other interpretations (...) discussed in the literature; third, we clarify common misconceptions. (shrink)

Estudio sobre una de las ciencias de la ciencia, la epistomología o filosofía de la ciencia que se encarga del estudio de la investigación científica y su producto, el conociemiento científico.

Esteban Lythgoe 55 Regímenes no democráticos y democracias menos republicanas Mario Serrafero 65 Precios e Instituciones Políticas en Buenos Aires (1850-1900) Eduardo Martín Cuesta 79.

Abstract We examine the construction of electromagnetism in its current form, and in an alternative form, from a point of view that combines a minimal realism with strict rational demands. We begin by discussing the requests of reason when constructing a theory and next, we follow the historical development as presented in the record of original publications, the underlying epistemology (often explained by the authors) and the mathematical constructions. The historical construction develops along socio-political disputes (mainly, the reunification of Germany (...) and the second industrial revolution), epistemic disputes (at least two demarcations of science in conflict) and several theories of electromagnetism. Such disputes resulted in the militant adoption of the ether by some, a position that expanded in parallel with the expansion of Prussia. This way of thinking was facilitated by the earlier adoption of a standpoint that required, as a condition for understanding, the use of physical hypothesis in the form of analogies; an attitude that is antithetic to Newton's “hypotheses non fingo”. While the material ether was finally abandoned, the epistemology survived in the form of “substantialism” and a metaphysical ether: the space. The militants of the ether attributed certainties regarding the ether to Faraday and Maxwell, when they only expressed doubts and curiosity. Thus, the official story is not the real history. This was achieved by the operation of detaching Maxwell's electromagnetism from its construction and introducing a new game of formulae and interpretations. Large and important parts of Maxwell work are today not known, as for example, the rules for the transformation of the electromagnetic potentials between moving systems. When experiments showed that all the theories based in the material ether were incorrect, a new interpretation was offered: Special Relativity (SR). At the end of the transformation period a pragmatic view of science, well adapted to the industrial society, had emerged, as well as a new protagonist: the theoretical physicist. The rival theory of delayed action at distance initiated under the influence of Gauss was forgotten in the midst of the intellectual warfare. The theory is indistinguishable in formulae from Maxwell's and its earlier versions are the departing point of Maxwell for the construction of his equations. We show in a mathematical appendix that such (relational) theory can incorporate Lorentz' contributions as well as Maxwell's transformations and C. Neumann's action, without resource to the ether. Demarcation criteria was further changed at the end of the period making room for habits and intuitions. When these intuited criteria are examined by critical reason (seeking for the fundaments) they can be sharpened with the use of the Non Arbitrariness Principle, which throws light over the arbitrariness in the construction of SR. Under a fully rational view SR is not acceptable, it requires to adopt a less demanding epistemology that detaches the concept from the conception, such as Einstein's own view in this respect, inherited from Hertz. In conclusion: we have shown in this relevant exercise how the reality we accept depends on earlier, irrational, decisions that are not offered for examination but rather are inherited from the culture. (shrink)

I want to combine two hitherto largely independent research projects, scientific understanding and mechanistic explanations. Understanding is not only achieved by answering why-questions, that is, by providing scientific explanations, but also by answering what-questions, that is, by providing what I call scientific descriptions. Based on this distinction, I develop three forms of understanding: understanding-what, understanding-why, and understanding-how. I argue that understanding-how is a particularly deep form of understanding, because it is based on mechanistic explanations, which answer why something happens in (...) virtue of what it is made of. I apply the three forms of understanding to two case studies: first, to the historical development of thermodynamics and, second, to the differences between the Clausius and the Boltzmann entropy in explaining thermodynamic processes. (shrink)

The ontological models framework distinguishes ψ-ontic from ψ-epistemic wave- functions. It is, in general, quite straightforward to categorize the wave-function of a certain quantum theory. Nevertheless, there has been a debate about the ontological status of the wave-function in the statistical interpretation of quantum mechanics: is it ψ-epistemic and incomplete or ψ-ontic and complete? I will argue that the wave- function in this interpretation is best regarded as ψ-ontic and incomplete.