The prospect of using cell-based interventions to treat neurological conditions raises several important ethical and policy questions. In this target article, we focus on issues related to the unique constellation of traits that characterize CBIs targeted at the central nervous system. In particular, there is at least a theoretical prospect that these cells will alter the recipients' cognition, mood, and behavior—brain functions that are central to our concept of the self. The potential for such changes, although perhaps remote, is cause (...) for concern and careful ethical analysis. Both to enable better informed consent in the future and as an end in itself, we argue that early human trials of CBIs for neurological conditions must monitor subjects for changes in cognition, mood, and behavior; further, we recommend concrete steps for that monitoring. Such steps will help better characterize the potential risks and benefits of CBIs as they are tested and potentially used for treatment. (shrink)

: Because an influenza pandemic would create the most serious hardships for those who already face most serious hardships, countries should take special measures to mitigate the effect of a pandemic on existing social inequalities. Unfortunately, there is little evidence that anybody is thinking about that.

© 2019 The Author. Background: The phenomenon of being 'with woman' is fundamental to midwifery as it underpins its philosophy, relationships and practices. There is an identified gap in knowledge around the 'with woman' phenomenon from the perspective of midwives providing care in a variety of contexts. As such, the aim of this study was to explore the experiences of being 'with woman' during labour and birth from the perspective of midwives' working in a model where care is provided by (...) a known midwife. Methods: A descriptive phenomenological design was employed with ten midwives working in a 'known midwife' model who described their experiences of being 'with woman' during labour and birth. The method was informed by Husserlian philosophy which seeks to explore the same phenomenon through rich descriptions by individuals revealing commonalities of the experience. Results: Five themes emerged 1) Building relationships; 2) Woman centred care; 3) Impact on the midwife; 4) Impact on the woman; and 5) Challenges in the Known Midwife model. Midwives emphasised the importance of trusting relationships while being 'with woman', confirming that this relationship extends beyond the woman - midwife relationship to include the woman's support people and family. Being 'with woman' during labour and birth in the context of the relationship facilitates woman-centred care. Being 'with woman' influences midwives, and, it is noted, the women that midwives are working with. Finally, challenges that impact being 'with woman' in the known midwife model are shared by midwives. Conclusions: Findings offer valuable insight into midwives' experiences of being 'with woman' in the context of models that provide care by a known midwife. In this model, the trusting relationship is the conduit for being 'with woman' which influences the midwife, the profession of midwifery, as well as women and their families. Descriptions of challenges to being 'with woman' provide opportunities for professional development and service review. Rich descriptions from the unique voice of midwives, provided insight into the applied practices of being 'with woman' in a known midwife model which adds important knowledge concerning a phenomenon so deeply embedded in the philosophy and practices of the profession of midwifery. (shrink)

© 2015, Springer-Verlag Berlin Heidelberg.Genetic studies have identified single nucleotide polymorphisms associated with the risk of prostate cancer. It remains unclear whether such genetic variants are associated with disease aggressiveness. The NCI-SPORE Genetics Working Group retrospectively collected clinicopathologic information and genotype data for 36 SNPs which at the time had been validated to be associated with PC risk from 25,674 cases with PC. Cases were grouped according to race, Gleason score and aggressiveness. Statistical analyses were used to compare the frequency (...) of the SNPs between different disease cohorts. After adjusting for multiple testing, only PC-risk SNP rs2735839 was significantly and inversely associated with aggressive and high-grade disease in European men. Similar associations with aggressive and high-grade disease were documented in African-American subjects. The G allele of rs2735839 was associated with disease aggressiveness even at low PSA levels in both European and African-American men. Our results provide further support that a PC-risk SNP rs2735839 near the KLK3 gene on chromosome 19q13 may be associated with aggressive and high-grade PC. Future prospectively designed, case-case GWAS are needed to identify additional SNPs associated with PC aggressiveness. (shrink)

This article examines overpopulation as a basis for historical interpretation. Drawing on the ideas of T.R. Malthus, Elizabeth Kolbert, John Lovelock, Lynn Margulis, and Edward O. Wilson, I make the case that the only concept of ‘progress’ that accurately describes the human enterprise is the uncontrolled growth of population. I explain why a Malthusian/Gaia interpretation is not a historicist or eschatological narrative, like Hegelian idealism, Marxism, fundamentalist religion, or ‘end of history’ neoliberalism. My article also includes a discussion of the (...) ideas and prescriptions of contemporary commentators like physicist, Adam Frank, and the philosophers, John Gray, and Roy Scranton. What makes my article distinctive is bringing together ideas of population theory through a lens of sociobiology and post-humanist philosophy. Through this interpretive synthesis, I form a basis for recasting history as the record of the growing imbalance of our species in light of the unprecedented crises of the environment that are its byproduct. I conclude with the idea that regardless of whether the world is dying or simply going through a fundamental chaotic transformation, the role of the critical-rational historian remains the same: to tell the truth as best as she or he can know it. (shrink)

The Nature of God explores a perennial problem in the philosophy of religion.

Reason and Value collects 15 new papers by leading contemporary philosophers on themes from the work of Joseph Raz. Raz has made major contributions in a wide range of areas, including jurisprudence, political philosophy, and the theory of practical reason; but all of his work displays a deep engagement with central themes in moral philosophy. The subtlety and power of Raz's reflections on ethical topics make his writings a fertile source for anyone working in this area. Especially significant are his (...) explorations of the connections between practical reason and the theory of value, which constitute a sustained and penetrating treatment of a set of issues at the very center of moral philosophy as it is practiced today. The contributors to the volume acknowledge the importance of Raz's contributions by engaging critically with his positions and offering independent perspectives on the topics that he has addressed. The volume aims both to honour Raz's accomplishments in the area of ethical theorizing, and to contribute to an enhanced appreciation of the significance of his work for the subject. (shrink)

I argue that rather than aiming at the well-being of those whom we love, we should aim to share in their ends. The former stance runs the risk of being objectionably paternalistic and, as I explain, only the latter makes reciprocal relationships possible. I end by diagnosing our attraction to the idea that we should promote our loved-ones’ well-being.

Benacerraf’s 1965 multiple-reductions argument depends on what I call ‘deferential logicism’: his necessary condition for number-set identity is most plausible against a background Quineanism that allows autonomy of the natural number concept. Steinhart’s ‘folkist’ sufficient condition on number-set identity, by contrast, puts that autonomy at the center — but fails for not taking the folk perspective seriously enough. Learning from both sides, we explore new conditions on number-set identity, elaborating a suggestion from Wright.

Rawls' requirement that citizens of liberal democracies support only policies which they believe can be justified in 'public reason' depends on a certain ideal for the relationships between citizens. This is a valuable ideal, and thus citizens have reasons to try to achieve it. But it is not always possible to find the common ground that we would need in order to do so, and thus we should reject Rawls' strong claim that we have an obligation to defend our views (...) in public reason. Because I recognize that we have strong reasons to conduct our political enquiry within the guidelines of political liberalism, but deny that we always have an obligation to do so, one might call my view 'permissive political liberalism'. (shrink)

Fallacies are things people commit, and when they commit them they do something wrong. What kind of activities are people engaged in when they commit fallacies, and in what way are they doing something wrong? Many different things are called fallacies. The diversity of the use of the concept of a fallacy suggests that we are dealing with a family of cases not related by a common essence. However, we suggest a simple account of the nature of fallacies which encompasses (...) them all, viz., the term “fallacy” is our most general term for criticizing any general procedure used for the fixation of beliefs that has an unacceptably high tendency to generate false or unfounded beliefs, relative to that method of fixing beliefs. Very different sorts of things called fallacies are examined in the light of this account, e.g., denying the antecedent, circular arguments, so-called informal fallacies, and propositions said to be fallacies. We do not provide a theory of fallacies. Still, on our account pretty much all of those things that have been called fallacies are fallacies, and they have been called fallacies for pretty much the same reasons. (shrink)

I attempt to vindicate our authority to create new practical reasons for others by making choices of own own. In The Doctrine of Right Kant argues that we have an obligation to leave the Juridical State of Nature and found the state. In a less familiar passage in Religion within the Bounds of Mere Reason he argues for an obligation to leave what he calls the Ethical State of Nature and join together in the Moral Community. I read both texts (...) as addressing and trying to resolve a tension between our individual freedom and our authority to make claims on one another. I explicate the political argument, and then develop the view that Kant sketches in the Religion, arguing that regarding others as capable of making choices that give you reasons to act is a condition of the full exercise of your autonomy. (shrink)

It is known that, on average, people adapt their choice of memory strategy to the subjective utility of interaction. What is not known is whether an individual's choices are boundedly optimal. Two experiments are reported that test the hypothesis that an individual's decisions about the distribution of remembering between internal and external resources are boundedly optimal where optimality is defined relative to experience, cognitive constraints, and reward. The theory makes predictions that are tested against data, not fitted to it. The (...) experiments use a no-choice/choice utility learning paradigm where the no-choice phase is used to elicit a profile of each participant's performance across the strategy space and the choice phase is used to test predicted choices within this space. They show that the majority of individuals select strategies that are boundedly optimal. Further, individual differences in what people choose to do are successfully predicted by the analysis. Two issues are discussed: the performance of the minority of participants who did not find boundedly optimal adaptations, and the possibility that individuals anticipate what, with practice, will become a bounded optimal strategy, rather than what is boundedly optimal during training. (shrink)

We often come to value someone or something through experience of that person or thing. You may thereby come to embrace a value that you did not grasp prior to the experience in question. Moreover, it seems that in a large and important subset of cases you could not have fully appreciated that value merely by considering a report of the reasons or arguments that purport to establish that it is valuable. Despite its ubiquity, this phenomenon goes missing in a (...) great deal of contemporary work in ethics and political philosophy. In this paper I further specify the phenomenon of interest by developing a series of examples. Then I support the claim that philosophers routinely overlook it by surveying several significant philosophical positions that do so. (shrink)

Kant’s political theory stands in the social contract tradition, but departs significantly from earlier versions of social contract theory. Most importantly Kant holds, against Hobbes and Locke, that we have not merely a pragmatic reason but an obligation to exit the state of nature and found a state. Kant holds that each person has an innate right to freedom, but it is possible to simultaneously honor everyone’s right only under the rule of law. Since we are obligated to respect each (...) person’s right to freedom, and can do so only in a state, we are obligated to submit to the authority of the state if we have one, and to establish one if we do not. In the first half of the essay I reconstruct this argument in more detail. In the second half I survey four points of controversy: (i) What is the relationship between Kant’s political philosophy and his moral philosophy? (ii) How does the innate right to freedom support the postulate that we are permitted to acquire property and other private rights? (iii) How does the postulate support an obligation to found the state? (iv) How should we understand Kant’s views about political revolutions? (shrink)

Many recent writers in the philosophy of mathematics have put great weight on the relative categoricity of the traditional axiomatizations of our foundational theories of arithmetic and set theory. Another great enterprise in contemporary philosophy of mathematics has been Wright's and Hale's project of founding mathematics on abstraction principles. In earlier work, it was noted that one traditional abstraction principle, namely Hume's Principle, had a certain relative categoricity property, which here we term natural relative categoricity. In this paper, we show (...) that most other abstraction principles are not naturally relatively categorical, so that there is in fact a large amount of incompatibility between these two recent trends in contemporary philosophy of mathematics. To better understand the precise demands of relative categoricity in the context of abstraction principles, we compare and contrast these constraints to stability-like acceptability criteria on abstraction principles, the Tarski-Sher logicality requirements on abstraction principles studied by Antonelli and Fine, and supervaluational ideas coming out of Hodes' work. (shrink)

R. G. Swinburne; XIII*—Personal Identity, Proceedings of the Aristotelian Society, Volume 74, Issue 1, 1 June 1974, Pages 231–247, https://doi.org/10.1093/arist.

Neo-Fregeans have been troubled by the Nuisance Principle, an abstraction principle that is consistent but not jointly satisfiable with the favored abstraction principle HP. We show that logically this situation persists if one looks at joint consistency rather than satisfiability: under a modest assumption about infinite concepts, NP is also inconsistent with HP.

I argue that we cannot adequately characterize the aims of education in terms of some formal conception of what it is to think well. Implementing any such aim requires reliance on and communication of further, substantive normative commitments. This reveals that a standard contrast between an old-fashioned approach to education that aims to communicate a particular normative outlook, and a progressive approach that aims to develop skills of critical reasoning and reflection is confused and misleading.

This article improves two existing theorems of interest to neologicist philosophers of mathematics. The first is a classification theorem due to Fine for equivalence relations between concepts definable in a well-behaved second-order logic. The improved theorem states that if an equivalence relation E is defined without nonlogical vocabulary, then the bicardinal slice of any equivalence class—those equinumerous elements of the equivalence class with equinumerous complements—can have one of only three profiles. The improvements to Fine’s theorem allow for an analysis of (...) the well-behaved models had by an abstraction principle, and this in turn leads to an improvement of Walsh and Ebels-Duggan’s relative categoricity theorem. (shrink)

The injective version of Cantor’s theorem appears in full second-order logic as the inconsistency of the abstraction principle, Frege’s Basic Law V (BLV), an inconsistency easily shown using Russell’s paradox. This incompatibility is akin to others—most notably that of a (Dedekind) infinite universe with the Nuisance Principle (NP) discussed by neo-Fregean philosophers of mathematics. This paper uses the Burali–Forti paradox to demonstrate this incompatibility, and another closely related, without appeal to principles related to the axiom of choice—a result hitherto unestablished. (...) It discusses both the general interest of this result, its interest to neo-Fregean philosophy of mathematics, and the potential significance of the Burali–Fortian method of proof. (shrink)

This is the second of the three volumes comprising, Scholastic Humanism and the Unification of Europe. Focussing on the period from c.1090-1212, the volume explores the lives, scholarly resources, and contributions of a wide sample of people who either took part in the creation of the scholastic system of thought or gave practical effect to it in public life. The second volume of a compelling, original work which will redefine our perceptions of medieval civilization, the renaissance and the evolution of (...) modern Europe. Written by a man who was widely regarded as the greatest medieval historian. (shrink)

Objects appear to fall into different sorts, each with their own criteria for identity. This raises the question of whether sorts overlap. Abstractionists about numbers—those who think natural numbers are objects characterized by abstraction principles—face an acute version of this problem. Many abstraction principles appear to characterize the natural numbers. If each abstraction principle determines its own sort, then there is no single subject-matter of arithmetic—there are too many numbers. That is, unless objects can belong to more than one sort. (...) But if there are multi-sorted objects, there should be cross-sortal identity principles for identifying objects across sorts. The going cross-sortal identity principle, ECIA2 of Cook and Ebert (2005), solves the problem of too many numbers. But, I argue, it does so at a high cost. I therefore propose a novel cross-sortal identity principle, based on embeddings of the induced models of abstracts developed by Walsh (2012). The new criterion matches ECIA2’s success, but offers interestingly different answers to the more controversial identifications made by ECIA2. (shrink)

This anthology consists of a collection of papers on the nature of dis positions and the role of disposition concepts in scientific theories. I have tried to make the collection as representative as possible, except that problems specifically connected with dispositions in various special sciences are relatively little discussed. Most of these articles have been previously published. The papers by Mackie, Essler and Trapp, Fetzer (in Section 11), Levi, and Tuomela appear here for the first time, and are simultaneously published (...) in Synthese 34, No. 4, which is a special issue on dispositions. Of the previously published material it should be emphasized that the papers by Hempel and Fisk have been extensively revised specially for this anthology. The papers are grouped in four sections, partlyon the basis of their content. However, due to the complexity of the issues involved, there is considerable overlap in content between the different sections, especially between Sections land 11. I wish to thank Professors James Fetzer and Carl G. Hempel for helpful advicc in compiling this anthology. (shrink)

I argue that unfortunate formative circumstances do not undermine the warrant for either responsibility or blame. I then diagnose the tendency to think that formative circumstances do matter in this way, arguing that knowledge of these circumstances can play an essential epistemic role in our interpersonal interactions.

Our ordinary talk reflects a deep tension in the way that we think about love. On the one hand, we regard love as an especially important expression of our agency. Yet, on the other hand, we also think of love as something that happens to us, in the face of which we are passive and can be powerless. While it’s hard to see how to hold these two ways of thinking of love together, in this paper I argue that we (...) must find some way of doing so. I argue that we must think of love as a contentful attitude attributable to its agent, an expression of our selves. But familiar ways of understanding agency sort love into the category of things that happen to us, rather than that of things that we do: You cannot love at will, nor is love an attitude to which you could reason. I conclude that questions about the relationship of our agency to what we love are not superficial, but stem from deep tensions about the relationship between love and reasons. A resolution to these difficulties would provide important insight not only into the character of love, but also the nature of agency, and its relationship to values, reasoning and reasons. (shrink)

Berislav Marušić’s On the Temporality of Emotions is a lovely book. Marušić confronts a puzzle about grief and anger that many will find familiar from their own.

It is often alleged that an agent is morally responsible in a liability sense for a transgression just in case s/he deserves a negative interpersonal response for that transgression, blaming responses such as resentment and indignation being paradigms. Aside from a few exceptions, guilt is cited in recent discussions of moral responsibility, if at all, as merely an effect of being blamed, or as a reliable indicator of moral responsibility, but not itself an explanation of moral responsibility. In this paper, (...) I argue that an agent is morally responsible in a liability sense for a transgression just in case s/he deserves to feel moral guilt for that transgression. I argue that this alternative view offers all that the predominant blame-focused view offers, while also solving some puzzling features of moral responsibility. Specifically, it offers a compelling way to reconcile conflicting intuitions about the suberogatory, and allows those who do not understand what Darwall calls ‘second-personal’ reasons to be morally responsible for their immoral acts. (shrink)

Inspired by impossibility theorems of social choice theory, many democratic theorists have argued that aggregative forms of democracy cannot lend full democratic justification for the collective decisions reached. Hence, democratic theorists have turned their attention to deliberative democracy, according to which “outcomes are democratically legitimate if and only if they could be the object of a free and reasoned agreement among equals” (Cohen 1997a, 73). However, relatively little work has been done to offer a formal theory of democratic deliberation. This (...) article helps fill that gap by offering a formal theory of three different modes of democratic deliberation: myopic discussion, constructive discussion, and debate. We show that myopic discussion suffers from indeterminacy of long run outcomes, while constructive discussion and debate are conclusive. Finally, unlike the other two modes of deliberation, debate is path independent and converges to a unique compromise position, irrespective of the initial status quo. (shrink)

Despite All Critique (2014) -- World Politics and Western Reason (1980) -- The Doubled Outsides of the Modern International (2005) -- The Subject of Security (1995) -- The Protection of Nature and the Nature of Protection (2005) -- Social Movements/World Politics (1994) -- Europe is Not Where It is Supposed to Be (2000) -- They Seek it Here, They Seek it There : Looking for Politics in Clayoquot Sound (2003) -- Violence, Modernity, Silence : From Weber to International Relations (1993) (...) -- Hobbes, Origins, Limits (2011) -- War, Terror, Judgement (2002) -- International, Imperial, Exceptional (2005) -- Which Democracy for Which Demos? (2013) -- The Political Theory of Boundaries and the Boundaries of Political Theory : Interview With Raia Prokhovnik (2012). (shrink)

What is xenophobia? Why is xenophobia immoral? How is xenophobia's conceptual and moral meaning diminished? Investigations of these questions would invigorate xenophobia as a topic in public morality and discourage the public's acquiescing to xenophobia's new prominence. This paper focuses on the third question, the diminishment of xenophobia. In the first section, I outline a general conception of xenophobia. In the second, I explain how theories of membership in liberal democratic societies relegate xenophobia to a minor moral concern. And, in (...) the third, that the conflation of xenophobia with racism disadvantages the former. How liberal Democratic nations imagine membership and how those nations imagine racism shelters xenophobia. (shrink)

Christine M. Korsgaard has had a profound influence on moral philosophy over the past forty years. Through her writing and teaching she has developed a distinctive, rigorous, and historically informed way of thinking about ethics, agency, and the normative dimension of human life more generally. The twelve original essays in this volume are written in her honor on the occasion of her retirement from teaching. They engage questions that recur in her work: Why are we obligated to do what morality (...) demands? What features of our nature make us subject to moral obligation? What does it mean to be autonomous and responsible for what we do? What do we owe to nonhuman animals? Contributors include Stephen Darwall, Kyla Ebels-Duggan, Barbara Herman, Richard Moran, Japa Pallikkathayil, Faviola Rivera-Castro, T.M. Scanlon, Tamar Schapiro, Sharon Street, David Sussman, Sigrún Svavarsdóttir, and David Velleman. These essays shed light on Korsgaard's own views while staking out provocative new positions on the topics that feature centrally in her own work. (shrink)