Der Streit um die Prinzipien der Theorienentwicklung hat in den Jahren seit dem Erscheinen von TH. S. KUHNS "Die Struktur wissen schaftlicher Revolutionen" mannigfache und lebhafte AufSerungen pro und contra hervorgerufen. Die Gegenposition wird im wesent lichen durch die Namen POPPER und LAKATOS charakterisiert. Die Kontroverse erweist sich als eine solche zwischen synchronischer und diachronischer, zwischen systematischer und historischer Betrach tungsweise. 1st die Entwicklung der Wissenschaften, wie man es nach KUHN glauben kann, in entscheidendem MafSe aufSeren Einfliissen und Zufalligkeiten ausgesetzt, (...) oder gibt es nicht doch rationale, rein wissenschaftsimmanente Kriterien, auf Grund derer eine Entwicklung im Sinne eines Fortschrittes zu immer besseren, richtigeren und lei stungsfahigeren Theorien moglich ist? Eine wesentliche Schwierigkeit, um dabei weiterzukommen, besteht darin, dafS es keine Moglichkeit zu geben scheint, eine Theorie zu bewerten, zu entscheiden, welche von zwei Theorien "wahrscheinlicher, richtiger, besser oder leistungs fahiger" ist. Wenn es geiange, eine numerische Bewertung von Hypothesen und Theorien in dieser Richtung zu finden, so ware damit auch ein Weg gewiesen, die Entwicklung der Theorien nicht nur zu rekon struieren, sondern vielleicht auch zu lei ten. Die Bewertung einer Theorie im Sinne ihrer Richtigkeit ist bisher nicht gelungen. Wenn POPPER, insbesondere in seinen spaten Arbeiten ("Objective Knowl edge"), die Auffassung vertritt, dafS die Entwicklung der Wissen schaften im Sinne einer immer grofSeren Wahrheitsahnlichkeit von statten gehe, so ist das bei ihm ein reiner Glaube, der auf Grund seines Modells von Versuch und Irrtum postuliert wird. (shrink)

With great sympathy for Roman Ingarden and his work, Edith Stein edited his book project The Literary Work Of Art. In the letters she exchanges with him shereflects on relationship between reality and ideality: she writes that those who do not see the world as a reality must be fools. The political events in the 1930s had an impact on phenomenology. While Edmund Husserl dissociates himself from his protégé Martin Heidegger with regard to the content of his philosophy as well (...) as with regard to his ideology, Edith Stein distances herself more and more from the phenomenological method, seeing it as removed from reality, and she eventually become a Carmelite nun. Roman Ingarden, on the other hand, reconsiders interpreting phenomenology as aesthetic theory. Literature and film are being re-analysed in terms of phenomenological mediality and as factors of human communication. (shrink)

The article presents the sociology of knowledge approach to discourse (SKAD). SKAD, which has been in the process of development since the middle of the 1990s, is now a widely used framework among social scientists in discourse research in the German-speaking area. It links arguments from the social constructionist tradition, following Berger and Luckmann, with assumptions based in symbolic interactionism, hermeneutic sociology of knowledge, and the concepts of Michel Foucault. It argues thereby for a consistent theoretical and methodological grounding of (...) a genuine social sciences perspective on discourse interested in the social production, circulation and transformation of knowledge, that is in social relations and politics of knowledge in the so-called ‘knowledge societies’. Distancing itself from Critical Discourse Analysis, Linguistics, Ethnomethodology inspired discourse analysis and the Analysis of Hegemonies, following Laclau and Mouffe, SKAD’s framework has been built up around research questions and concerns located in the social sciences, referring to public discourse and arenas as well as to more specific fields of (scientific, religious, etc.) discursive struggles and controversies around problematizations (Foucault). (shrink)

Haunted by dreams of a powerful red tide, Odd Thomas, accompanied by two otherworldly sidekicks--his dog Boo and the Chairman of the Board--is drawn to a small California coastal town, where nothing is at it appears and where he confronts overwhelming and sinister forces out to stop his quest.

This paper puts forward a theoretical framework for the analysis of expertise and experts in contemporary societies. It argues that while prevailing approaches have come to see expertise in various forms and functions, they tend to neglect the broader historical and societal context, and importantly the relational aspect of expertise. This will be discussed with regard to influential theoretical frameworks, such as laboratory studies, regulatory science, lay expertise, post-normal science, and honest brokers. An alternative framework of expertise is introduced, showing (...) the limitations of existing frameworks and emphasizing one crucial element of all expertise, which is their role in guiding action. (shrink)

Justice, Sustainability, and Security not only enhances our knowledge of these issues, but it teases out our moral dimensions and offer prescriptions for how governments and global actors might craft their policies to better consider their effects on the global human condition.

This junior/senior level text is devoted to a study of first-order logic and its role in the foundations of mathematics: What is a proof? How can a proof be justified? To what extent can a proof be made a purely mechanical procedure? How much faith can we have in a proof that is so complex that no one can follow it through in a lifetime? The first substantial answers to these questions have only been obtained in this century. The most (...) striking results are contained in Goedel's work: First, it is possible to give a simple set of rules that suffice to carry out all mathematical proofs; but, second, these rules are necessarily incomplete - it is impossible, for example, to prove all true statements of arithmetic. The book begins with an introduction to first-order logic, Goedel's theorem, and model theory. A second part covers extensions of first-order logic and limitations of the formal methods. The book covers several advanced topics, not commonly treated in introductory texts, such as Trachtenbrot's undecidability theorem. Fraissé's elementary equivalence, and Lindstroem's theorem on the maximality of first-order logic. (shrink)

In der Reihe werden herausragende monographische Untersuchungen und Sammelbände zu allen Aspekten der Philosophie Kants veröffentlicht, ebenso zum systematischen Verhältnis seiner Philosophie zu anderen philosophischen Ansätzen in Geschichte und Gegenwart. Veröffentlicht werden Studien, die einen innovativen Charakter haben und ausdrückliche Desiderate der Forschung erfüllen. Die Publikationen repräsentieren damit den aktuellsten Stand der Forschung.

Pathogenic variants occurring in protein‐coding regions underlie human genetic disease through various mechanisms. They can lead to a loss of function (LOF) such as in recessive conditions or in dominant conditions due to haploinsufficiency. Dominant‐negative (DN) effects, counteracting the activity of the normal gene‐product, and gain of function (GOF) are also mechanisms driving dominance. Here, I discuss a few papers on these specific mechanisms. In short, there is accumulating evidence pointing to differences between LOF versus non‐LOF variants (DN and GOF). (...) The latter are thought to have milder effects on protein structure and, as expected, DN variants are enriched at protein interfaces. This tendency to cluster in 3D space can help improve the ability of computational tools to predict the pathogenicity of DN variants, which is currently a challenging issue. More recent results support the hypothesis whereby cotranslational assembly of macromolecular complexes can buffer deleterious consequences of variants that would otherwise lead to DN effects (DNEs). Indeed, subunits the variants of which are responsible for DNEs tend to elude cotranslational assembly, thus poisoning complexes involving wild‐type subunits. The constraints explaining why the buffering of DNEs is not universal require further investigation. (shrink)

Testis determination in most mammals is regulated by a genetic hierarchy initiated by the SRY gene. Early ovarian development has long been thought of as a default pathway switched on passively by the absence of SRY. Recent studies challenge this view and show that the ovary constantly represses male‐specific genes, from embryonic stages to adulthood. Notably, the absence of the crucial ovarian transcription factor FOXL2 (alone or in combination with other factors) induces a derepression of male‐specific genes during development, postnatally (...) and, even more interestingly, during adulthood. Strikingly, in the adult, targeted ablation of Foxl2 leads to a molecular transdifferentiation of the supporting cells of the ovary, which acquire cytological and transcriptomic characteristics of the supporting cells of the testes. These studies bring many answers to the field of gonadal determination, differentiation and maintenance, but also open many questions. (shrink)

Expression of most genes is regulated by the interaction of multiple transcription factors with cis‐regulatory sequences. Many studies have focused on how changes in promoters and enhancers alter gene expression and phenotype. Recently, Hare et al., using elegant wet and computational approaches uncovered a series of enhancers driving the expression of the even‐skipped gene in scavenger flies (Sepsidae).1 Despite the strong sequence divergence between the enhancers in sepsids and drosophilids, they lead to remarkably similar patterns of gene expression in transgenic (...) Drosophila embryos. This can be explained by the existence of intra‐enhancer compensatory mutations and the presence of overlapping/near binding sites for activators and repressors. BioEssays 30:1052–1057, 2008. © 2008 Wiley Periodicals, Inc. (shrink)

Der Autor: Reiner Ruffing ist promovierter Philosoph, gibt in der Erwachsenenbildung und an Universitäten Lehrveranstaltungen und ist seit mehr als 20 Jahren Lehrer.

This is not a work of mine. For some reason, I am unable to remove it from my page. It is a list of Dr. Reiner Schürmann's lecture notes for courses that he taught at the New School for Social Research (aka The New School).

Mehr noch als bei einem anderen Text mag für ein Vorwort gelten, daß die Schwierigkeit darin besteht, alles das, was einem nach Fertigstellung eines Buches zunächst dazu einfällt - und am liebsten würde man nur darüber schreiben! - wegzulassen, um dann dennoch auf einige wenige Punkte zurückzukommen, die der Autor als für das Lesepublikum wichtig erachtet. Mein Interesse für Hellerentstand aus einem universitären Rahmen heraus. Ich kam an der FU Berlin Anfang der 80er Jahre über Svetozar Stojanovic, der einige Gastvorträge (...) am Otto-Suhr-Institut hielt, mit der Philosophie der jugoslawischen "Praxis-Gruppe" in Kontakt, deren Grundlegung eines Hu manistischen Marxismus mich interessierte: Praxis als Schlüsselbegriff, Selbsterschaffung des Menschen, Verbindung von mittelbarer und unmittel barer Demokratie, auch die -wenn auch skeptische -Handhabung solcher wertgeladenen Begriffe wie Entfremdung und deren mögliche Überwindung, das waren, so empfand ich damals, Fingerzeige für einen neuen Dritten Weg zwischen Ost und West, denn die "Praxis-Gruppe" kritisierte mit existentiellem Einsatz den damals bestehenden Sozialismus, ohne das westliche Gesellschaftsmodell zu glorifizieren. Die Ideen der "Praxis-Gruppe" waren nicht eigentlich falsch; aber wahr scheinlich ist es mit Theorien wie mit Lebensaltern: sie haben ihre Phase, dann kommt etwas Neues. Nur daß bei der "Praxis-Gruppe" theoretisch nichts wesentlich Neues mehrkam. Für den an Theorie Interessierten glänztejedoch, aus dem Spektrum des Humanistischen Marxismus hervorkommend, schon bald ein neuer Name, nämlich derjenige von Agnes Heller. (shrink)

Nietzsches Aufforderung Bleibt der Erde treu! aus dem Zarathustra wollte er als eine Art Arznei gegen den drohenden Werteverfall in Europa verstanden wissen. Wie ein Arzt die korperlichen, so versuchte Nietzsche die Ursachen fur die geistigen Leiden in unserer Kultur aufzuspuren. Uberdruss und Langeweile, obwohl es den meisten Menschen in der westlichen Zivilisation nicht schlecht gehe, kamen ihm wie ein Frevel am Sinn der Erde vor. Mit seiner dionysischen Philosophie glaubte Nietzsche das Grundproblem seines Lebens losen zu konnen: wie es (...) namlich moglich sei, trotz der pessimistischen Einsicht in den leidvollen und letztlich unergrundlichen Charakter des Daseins einen praktischen Optimismus zu entwickeln. Im Fokus des Buches stehen so erkenntnistheoretische Aspekte und ihre Bedeutung fur Fragen der Lebensfuhrung. Nach einem Uberblick uber Leben und Werk orientiert sich der Aufbau des Bandes an Nietzsches Hauptbegriffen. Vergleiche mit anderen Autoren machen Nietzsches Philosophie aus dem Kontext heraus besser verstandlich, ein Glossar schlusselt zentrale Begriffe auf. (shrink)

It is often said that knowledge is power, but more often than not relevant knowledge is not used when political decisions are made. This book examines how political decisions relate to scientific knowledge and what factors determine the success of scientific research in influencing policy. The authors take a comparative and historical perspective and refer to well-known theoretical frameworks, but the focus of the book is on three case studies: the discourse of racism, Keynesianism, and climate change. These cases cover (...) a number of countries and different time periods. In all three the authors see a close link between 'knowledge producers' and political decision makers, but show that the effectiveness of the policies varies dramatically. This book will be of interest to scientists, decision makers and scholars alike. (shrink)

"... elegant and provocative... Exhibit[s] a subtle mastery of Heidegger's works." —Review of Metaphysics "... splendidly precise study of Heidegger... to be recommended not only to Heidegger scholars but also to those interested in the question of what philosophical thinking has as its task in the modern technological world." —Religious Studies Review "... indispensable to understanding the later Heidegger." —Choice.

In late 2009, e-mails from a server at the Climate Research Unit at the University of East Anglia were released that showed some climate scientists in an unfavorable light. Soon this scandal was known as “Climategate” and a highly charged debate started to rage on blogs and in the mass media. Much of the debate has been about the question whether anthropogenic global warming was undermined by the revelations. But ethical issues, too, became part and parcel of the debate. This (...) article aims to contribute to this debate, assessing the e-mail affair in the light of two normative analyses of science, one proposed by Robert Merton, the second by a recent suggestion to use the concept of honest brokering in science policy interactions. On the basis of these analyses, different aspects of malpractice will be discussed and possible solutions will be suggested. (shrink)

Speaking about the influence Husserl had on his early thinking Heidegger later on always referred to Husserl's 'Logische Untersuchungen', emphasizing the attitude of critical distance he had towards the "Ideen zu einer reinen Phänomenologie und phänomenologischen Philosophie" and Husserl's transcendental phenomenology pointed out there. Nevertheless, as shown in this paper, it is evident that in 'Being an Time' Heidegger took over some essential issues from Husserl's later work. But it is also clear that he was also essentially changing their character.

ABSTRACTExpertise has come under attack not least since the Brexit vote in the UK and Donald Trump’s election as President of the United States. In this contribution, I will provide some conceptual clarification and suggest a new topology of expertise. I will also examine the historical roots of this challenge to expertise and its social context using a comparative lens. I will ask what it could mean to speak of the rightful place of expertise. I will try to provide an (...) answer by looking more closely at different types of expertise. Expertise, it seems, has been used as an umbrella term for a variety of different knowledge-related activities. I will show that the role of the expert has to be differentiated from the role of the scientist, but also from the role of the specialist. Specialists have different tasks in comparison to experts which need to be emphasized. My argument will draw on the social and historical context of the critique of expertise, and discuss the challenge to the social sciences, espec... (shrink)